- Original research
Comparison of whole-body computed tomography vs selective radiological imaging on outcomes in major trauma patients: a meta-analysis
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicinevolume 22, Article number: 54 (2014)
The purpose of this meta-analysis was to explore the value of whole-body computed tomography (WBCT) in major trauma patients (MTPs).
A comprehensive search for articles from Jan 1, 1980 to Dec 31, 2013 was conducted through PubMed, Cochrane Library database, China biology medical literature database, Web of knowledge, ProQuest, EBSCO, OvidSP, and ClinicalTrials.gov. Studies which compared whole-body CT with conventional imaging protocol (X-ray of the pelvis and chest, trans-abdominal sonography, and/or selective CT) in MTPs were eligible. The primary endpoint was all-cause mortality. The second endpoints included: time spent in the emergency department (ED), the duration of mechanical ventilation, ICU and hospital length of stay (LOS), the incidence of Multiple Organ Dysfunction Syndrome (MODS) /Multiple Organ Failure (MOF). Analysis was performed with Review Manager 5.2.10 and Stata 12.0.
Eleven trials enrolling 26371 patients were analyzed. In MTPs, the application of WBCT was associated with lower mortality rate (pooled OR: 0.66, 95% CI: 0.52 to 0.85) and a shorter stay in the ED (weighted mean difference (WMD), –27.58 min; 95% CI, –43.04 to –12.12]. There was no effect of WBCT on the length of ICU stay (WMD, 0.95 days; 95% CI: –0.08 to 1.98) and the length of hospital stay (WMD, 0.56 days; 95% CI: –0.03 to 1.15). Patients in the WBCT group had a longer duration of mechanical ventilation (WMD, 0.96 days, 95% CI: 0.32 to 1.61) and higher incidence of MODS/MOF (OR, 1.44, 95% CI: 1.35-1.54; P = 0.00001).
The present meta-analysis suggests that the application of whole-body CT significantly reduces the mortality rate of MTPs and markedly reduces the time spent in the emergency department.
Trauma is the leading cause of death among people aged 1 to 45 years. In 2010, nearly 5.1 million people died from injuries -. Early diagnosis and treatment are usually the key elements to major trauma patients (MTPs) . There have been studies reporting that a reduction of the diagnostic interval is associated with better prognosis -. Regarding this, recent guidelines for the management of bleeding and coagulopathy recommend that the time elapsed between injury and operation should be minimized . Plain X-rays of the chest and pelvis, focused assessment sonograph trauma (FAST), and organ-specific computed tomography (CT) are conventional evaluation methods in the early diagnostic work-up in MTPs which is recommended by the Advanced Trauma Life Support (ATLS®) protocol ,. However, it often results in misdiagnosis of some potential life-threatening solid organ injuries and is time-consuming ,-.
During the last decades, CT has played a pivotal role in the early evaluation of MTPs. High resolution multi-slice CT (HRCT) is more sensitive in detecting various occult injuries, especially those potentially life-threatening injuries. Also HRCT is more reliable in excluding underlying injuries -. Meanwhile, the introduction of multi-slice helical CT (MSCT) has significantly shortened the scanning time . In some developed nations, an increasing number of trauma centers use whole-body CT (WBCT) (defined as a CT scan including the head, neck, chest, abdomen, pelvis, and spine) as an early evaluation tool in MTPs. Moreover, in some trauma centers, CT scanner has been located within the emergency department or trauma bay so as to reduce the time from patient’s arrival to WBCT . Recently, clinicians have recognized the advantages of WBCT (especially its diagnostic superiority and time gain) ,. In addition, there are growing studies indicate that the integration of WBCT into the early assessment protocol significantly increases the probability of survival in those who are severely injured -. Huber-Wagner and colleagues reported that WBCT during trauma resuscitation is associated with a lower risk of mortality in patients regardless of their hemodynamic status ,. Patients with unstable hemodynamics can be left in their single position to complete the WBCT .
Although the proportion of use of WBCT in major trauma has been increased (from 5% in 2002 to 46% in 2010) ,, greater radiation expose becomes one of the major concern for the public because it may induce potential adverse outcomes. For example, the risk of dying from radiation induced cancer is estimated to be 0.08% after one single WBCT in a 45-year old patient . And 1.5%-2.0% malignant tumors are associated with radiation expose in CT scan in America . However, in the field of trauma, it remains inconclusive whether WBCT should be used as an initial assessment tool in MTPs. ,. Two previous published meta-analysis reported that the application of immediate WBCT has no effect on mortality in MTPs ,. Recently, several large-scale studies have indicated that the integration of WBCT into initial trauma management can decrease mortality in MTPs. As such, it is high time that those findings should be systematically analyzed.
A systematical search of literatures was performed until December 2013, using Cochrane Library database, PubMed, Web of knowledge, ProQuest, EBSCO, OvidSP, China Biology Medicine (http://www.Sinomed.ac.cn) and http://www.clinicaltrials.gov. The following keywords and medical subject headings were used: WBCT, FBCT, TBCT, whole body CT, full body CT, total body CT, pan scan, pan CT, whole body computed tomography, MSCT, MDCT, multi-slice spiral CT, multi-detector CT, multi-slice spiral computed tomography, multi-detector computed tomography, trauma, wound*, injur*, multiple trauma, multiple injur*, severe injur*, severe trauma, polytrauma, and major trauma. We also checked the reference lists of existing systematic reviews and other eligible studies to minimize potential publication bias. The detailed search strategies are available in Additional file 2.
We included studies that met the following criteria:
Patients: adult blunt MTPs (age > 16 years, injury severity score (ISS) > 16).
Comparisons: studies compared WBCT with conventional diagnostic algorithm (NWBCT, including X-rays of the chest and pelvis and FAST followed by selective CT or no CT).
Outcomes: The primary endpoint was all-cause mortality rate. The secondary endpoints included: time spent in the emergency department (ED), the duration of mechanical ventilation, ICU and hospital length of stay (LOS), the incidence of Multiple Organ Dysfunction Syndrome (MODS)/Multiple Organ Failure (MOF).
Study design: Both randomized and observational studies.
Data extraction and quality assessment
Data were independently extracted by two reviewers (LBJ AND LGY), using a data extraction sheet. The following data were extracted: characteristics of studies, characteristics of patients, types of intervention and outcomes. If necessary, we would contact the corresponding authors to obtain additional information.
The methodological quality of all eligible studies was assessed using the Newcastle-Ottawa Scale (NOS). (www.ohri.ca/programs/clinical_epidemiology/oxford.asp).
Odds ratios (OR) with 95% confidence intervals (CI) were calculated for categorical variables and weighted mean differences (WMD) were calculated for continuous variables. If the published reports of clinical trials only reported the median, range and the size of the trial, we used these published parameters to estimate the mean and the variance (or standard deviation) for such trials according to the formulas described in the study by Hozo et al. . Heterogeneity was tested by the Chi2 test (P < 0.10 indicated statistically significant heterogeneity) and I2 statistic (I2 value >50% indicated significant heterogeneity). The random-effect model was used when there was significant heterogeneity (I2 value >50%); otherwise the fixed random-effect was used . A 2-sided P value < 0.05 was considered statistically significant. Sensitivity analysis was performed for the primary endpoint (mortality). Publication bias was quantitatively detected by Egger’s test . The absence of publication bias is indicated by P value >0.10 in Egger’s test. All statistical analyses were performed using STATA 12.0 software (SERIAL NO.40120519635) and RevMan 5.2.10 (http://tech.cochrane.org/revman/download).
The quality of evidence in this meta-analysis was assessed using the GRADE Guidelines ,. The quality of evidence is classified into four levels: high, moderate, low, and very low, according to the robustness of the evidence ,. This process was performed using GRADE pro 3.6 software (http://www.Gradeworkinggroup.org/toolbox/index.htm).
We obtained 11116 titles and abstracts through literature search. After screening for abstracts, 11100 duplicated and non-relevant studies were excluded. And the remaining 16 studies were fully read. Of these, 5 studies were excluded and the corresponding reasons were listed in the flow chart (Figure 1). Finally, 11 studies were included in quantitative synthesis ,-,,-. Literatures screening process and the reasons for exclusion were shown in Figure 1.
Study quality assessment
The methodological quality of all included studies was evaluated using the Newcastle-Ottawa Scale. It mainly included the following three aspects: 1) representativeness of the cohort. Ten studies received four stars, indicating that the representativeness of the cohorts was good ,-,,-. 2) Comparability. Nine studies received a maximum of two stars -,,-,, the remaining studies only received one star due to the reason that the exposed (WBCT) and non-exposed (NWBCT) individuals were not matched in the design and/or confounders were not adjusted for in the analysis ,. 3) Outcome. Six studies received two stars because of insufficient follow-up time -,,,. Detailed information are summarized in the Additional file 3.
Study characteristics and meta-analysis
Ten studies -,,- reported data on mortality, including four multi-center studies ,,, and six single-center studies ,,,,,. The characteristics and results of these studies were summarized in Table 1. Among the included 26210 patients, 14133 patients underwent WBCT. The injury severity was measured using ISS. Patients in the WBCT group had higher ISS than those in the control group in five studies -,,. On the contrary, in the study by Wada et al. , patients in the NWBCT group had higher ISS than those in the WBCT group. In the study of Hutter et al. , 831 patients were included after the introduction of a CT-scan policy. However, nearly 27% of these patients did not undergo WBCT, probably because they were less severe than other patients. Thus these patients were excluded so as to avoid selection bias ,. One of Huber-Wagner’s studies  was excluded due to the included patients in this study were analyzed in a more recent published study . The study by Bi et al.  was excluded because the baseline characteristics of two groups were not reported. We used a random-effects model for the meta-analysis of mortality due to significant heterogeneity among the studies (P < 0.00001; I2 = 82%). The combined OR (0.66, 95% CI: 0.52 to 0.85; P =0.001, Figure 2) showed significantly lower mortality in patients with WBCT compared to those with NWBCT. The Egger’s test did not show any evidence of publication bias (P = 0.349).
A sensitivity analysis was conducted to explore potential sources of heterogeneity (Additional file 3). In the studies by Hutter et al. and Wada et al. ,, the OR was very different from that of the rest of the studies. It was probably because of the sample size of the control group was too small (132 vs 20) in the study by Wada et al. . And 223 patients in the study by Hutter et al. were excluded due to relatively low injury severity . However, heterogeneity still persisted (data not shown) even when we added these patients to the analysis model . Therefore, a sensitivity analysis was performed after excluding the study by Hutter et al. . Our results showed that the association between WBCT and lower mortality did not change and the pooled OR was 0.77 (95% CI: 0.63 to 0.94; P = 0.009) with significant heterogeneity (I2 = 69%). Similarly, a sensitivity analysis was performed after excluding the study by Wada et al. , which revealed that WBCT was still significantly associated with lower mortality rate (OR, 0.72, 95% CI: 0.59 to 0.89; P = 0.002) with significant heterogeneity (I2 = 75%). Finally, a further sensitivity analysis was performed after simultaneously excluding these two studies. After pooling the remaining data, the pooled OR was 0.79 (95% CI: 0.74 to 0.84; P < 0.00001), which was similar to the above results with non-significant heterogeneity (I2 = 0%) (Figure 2).
As shown in Table 1, there were significant differences in baseline characteristics between two groups, especially the ISS values. Thus a sensitivity analysis was conducted to estimate the robustness of our meta-analysis. Studies were only included in this sensitivity analysis scenario if the study authors adjusted for important confounders, such as ISS values. We obtained adjusted OR and its 95% CI from five studies for the pooled results ,,,,. The pooled OR was 0.54 (95% CI: 0.37 to 0.79; P = 0.001) with significant heterogeneity (I2 = 89.7%). A sensitivity analysis was also conducted by excluding the study by Hutter et al. , in which the adjusted OR was very different from that of the rest of studies. The pooled OR was 0.81 (95% CI: 0.73 to 0.89; P = 0.000) with insignificant heterogeneity (I2 = 34.7%; P = 0.204). Sensitivity analysis was also conducted by adding the study by Bi et al. , which had a high risk of bias. The pooled OR was 0.64 (95% CI: 0.50 to 0.82; P = 0.0003) which is similar to 0.66 (95% CI: 0.52 to 0.85; P =0.001), indicating that this analysis is reliable.
Time spent in the emergency department (ED)
Time spent in the ED was reported in six studies (Table 2) ,,,,,. There were no significant differences between the groups in the study by Mao et al. , probably because the preparation time for WBCT was too long and the CT room was situated far from the trauma bay. In addition, time spent in the ED was significantly shorter in the WBCT group compared with those in the NWBCT group in the study by Huber-Wagner et al.  (Personal communication), Weninger et al. , Wurmb et al.  and Hutter et al. . The study by Bi et al.  was excluded due to insufficient data. Although heterogeneity was present (P < 0.00001; I2 = 99%), Time spent in the ED was significantly shortened after the introduction of WBCT (WMD = –27.58 min; 95% CI: –43.04 to –12.12; P = 0.0005; Figure 3).The Egger’s test demonstrated no evidence of publication bias (P = 0.577).
ICU -LOS (days)
Six studies -,,, reported data on ICU LOS (Table 3). There was no effect of WBCT on the length of ICU stay in the random-effect model (WMD = 0.95 days, 95% CI: -0.08 to 1.98, P = 0.07) (Figure 4). There was significant heterogeneity between studies (P < 0.00001; I2 = 92%). The Egger’s test demonstrated no evidence of publication bias (P = 0.855).
Duration of mechanical ventilation (days)
Data on the duration of mechanical ventilation were available in five studies ,,,, (Table 3). The results revealed that the WBCT was associated with longer duration of mechanical ventilation in the random-effect model, the WMD was 0.96 days (95% CI: 0.32 to 1.61, P = 0.003) (Figure 4) with significant heterogeneity (P < 0.00001; I2 = 88%). The Egger’s test demonstrated no evidence of publication bias (P = 0.728).
Three studies reported data on the length of hospital stay ,, (Table 3). There was no effect of WBCT on the length of hospital stay in the fixed-effect model (WMD, 0.56 days, 95% CI: -0.03 to 1.15; P = 0.06) (Figure 4), with no heterogeneity found between studies (P = 0.43; I2 = 0%). The Egger’s test demonstrated no evidence of publication bias (P = 0.185).
The incidence of MODS/ MOF
Data on the incidence of MODS/MOF were available in three studies ,, (Table 3). The incidence of MODS/MOF was significantly lower in the NWBCT group compared with the WBCT group in the studies by Huber-Wagner et al. and Hutter et al. ,. Whereas, there was no significant difference between the two groups in the study by Mao et al. . The incidence of MODS/MOF did not differ between the WBCT group and NWBCT group in the random-effect model (OR, 2.50, 95% CI: 0.82-7.65, P = 1.018), with significant heterogeneity found between studies (I2 = 92%) (Figure 2). The study by Hutter et al.  was excluded because the OR was very different from that of the rest of the studies. The pooled OR suggested that the incidence of MODS/MOF was higher in the WBCT group than in the control group (OR, 1.44, 95% CI: 1.35-1.54; P = 0.00001), with no heterogeneity (I2 = 0).
GRADE of evidence
The GRADE of the evidence was summarized in Table 4.
Our results indicated that the integration of WBCT into the early diagnostic protocol significantly increased the probability of survival in MTPs. We also found that patients in the WBCT group had a significantly shorter ED stay. And there was no effect of WBCT on the length of ICU and hospital stay. To our best knowledge, this is the first meta-analysis of current published trials on the use of WBCT in MTPs.
In addition, patients in the WBCT group have a longer duration of mechanic ventilation and a higher incidence of MODS/MOF, as compared with those in the control group. However, it's not yet clear if there is any true cause-and-effect relationship between the application of WBCT and these adverse outcomes. Firstly, this is probably a result of the reduction of the mortality rate in MTPs. Patients that would have died if without WBCT now survive being aware of the whole injury pattern obtained by WBCT early. Therefore, the higher incidence of MODS/MOF in the WBCT group probably because there are more MTPs survivors in the early phase of hospital care. It has been reported that the classic trimodal death distribution of death following injury (the first peak included immediate deaths, the second peak included early hospital death, and The third peak included the late deaths) has been changed and is much more skewed to early hospital death, largely due to better prehospital and intensive care ,. Therefore, the biggest challenge is to reduce early hospital mortality. From this perspective, there would seem to be a good rationale for use of WBCT in MTPs to reduce early hospital mortality. Secondly, patients in the WBCT group are more serious (higher ISS values) than those in the NWBCT group which also might account for the higher incidence of MODS/MOF, and longer duration of mechanical ventilation in the WBCT group.
Computed tomography (CT) possesses multiple advantages in MTPs. Firstly, compared with conventional diagnostic approaches, WBCT has higher accuracy especially in the diagnosis of solid organ injuries . Secondly, WBCT can significantly reduce time interval between patient’s arrival and the end of life saving procedures, the end of diagnostic procedures, and the beginning of emergency surgery ,,,. A delay of proper surgical care is associated with higher risk of preventable death in trauma care . Rieger et al. reported that it was possible to detect all injuries through WBCT and the time for diagnostic work-up was shortened by 50% as a result of the early use of WBCT. Thirdly, patients in the WBCT group have a shorter ED stay in comparison with those in the control group ,,. Hilbert and colleagues found that a new algorithm that integrating multi-slice CT into the early diagnostic protocol can significantly reduce the length of stay in the trauma room .
Some researchers hold that it is reasonable to screen MTPs (ISS ≥16) with WBCT ,,,,. However, how to accurately identify patients who are severely traumatized remains a problem. The conventional approach is based on injury mechanism, clinical symptom, and physiological indicators . However, under this triage criteria, almost 30% of patients were found to have an ISS below 16 (over-triage) ,. Unnecessary CT scanning not only can increase the risk of radiation expose, but also is associated with a substantial economic burden ,. Fortunately with the continuous improvement of CT scanning technology, especially after the introduction of iterative reconstruction techniques, the effective dose of WBCT has decreased from 10-20 mSv to 5-10 mSv . And it has been reported that compared to selective CT, WBCT induces no increased radiation dose in favorable situations . Sierink et al. recently reported that although MTPs (ISS≥16) in the WBCT group experienced higher radiation dose in the trauma room, the total radiation dose throughout hospital admission was comparable between groups . In short, the triage rule may need to be reevaluated.
Some limitations of this study deserve to be mentioned. Firstly, all included studies in this meta-analysis are observational, non-randomized studies. However, based on the available data, and the fact that WBCT has significantly speeded up the diagnosis and treatment process and increased the probability of survival in MTPs, we do not feel that randomized controlled trials (RCTs) can change the current evidence, and it is unethical currently. Secondly, there were significant differences in baseline characteristics between groups, especially the ISS values -,,,. Base-line demographic and clinical characteristics were well matched between the two groups in only two studies ,. Moreover, in three studies, the number of patients in the NWBCT and WBCT groups varied significantly which would increase the probability of type I error ,,. Thirdly, we cannot attribute the survival benefits to the application of WBCT directly, as it is well known that trauma mortality has been ameliorated in many developed countries due to the improved trauma management (not only the introduction of WBCT). Hutter et al.  and colleagues also reported that both the use and the availability of WBCT were associated with a lower risk of all-cause mortality. This indicates that temporal comparison is also a major confounder. Finally, we cannot rule out other residual confounding factors, such as type of the scanners, scanning methods, indications for WBCT, different inclusion criteria, the location of the scanners or potential publication bias.
Compared with conventional strategies for early diagnosis of major trauma patients, whole-body computed tomography is associated with a decreased mortality rate and can shorten the time spent in the emergency department.
Dr Jiang is guarantor of the paper, taking responsibility for the integrity of the work as a whole, from inception to published article. LBJ MZ YFM conceived and designed the experiments. LBJ SYJ LGY performed the literature search and review. LBJ, LGY, MZ, YFM evaluated the quality of literatures. LBJ LGY extracted relevant data. LBJ SYJ MZ YAX conducted the statistical analysis. LBJ SYJ LGY ZZZ wrote the manuscript. LBJ SYJ YFM LGY ZJZ YAX MZ read and approved the final manuscript.
Major trauma patients
Whole-body computed tomography
Intensive care unit length of stay
Multiple organ dysfunction syndrome
Multiple organ failure
Intensive care unit
Injury severity score
Weighted mean difference
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This work was performed at the Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University, School of Medicine and Research Institute of Emergency Medicine, Zhejiang University, Hangzhou, China. We thank Xiaojun He, MPH, for providing guidance on the statistical analysis. We also thank all the relevant staff of the EDs for assisting in the implementation of this study.
This work was funded by National 12th Five-Year Plan National Technology Support Program (2012BAI11B0).
The authors declare that they have no competing interests.