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Table 4 GRADE evidence profile

From: Comparison of whole-body computed tomography vs selective radiological imaging on outcomes in major trauma patients: a meta-analysis

  Illustrative comparative risks* (95% CI)   
Outcomes Assumed risk Corresponding risk Relative effect (95% CI) GRADE
  NWBCT WBCT   
Mortality 231 per 1000 190 per 1000 OR 0.66 low1,2
(180- 200) (0.52 - 0.85)
ED Time The mean ED time ranged across control groups from 82 to 144.7 min The mean ED time in the intervention groups was 27.58 lower (43.04 to 12.12 lower) NR low1,2,3,4
ICU-LOS The mean ICU-LOS ranged across control groups from 1 to 16.8 days The mean ICU-LOS in the intervention groups was 0.95 higher (0.08 Lower to 1.98 higher) NR very low1,2,5
Ventilation Time The mean duration of mechanical ventilation ranged across control groups from 0 to 14.3 days The mean duration of mechanical ventilation in the intervention groups was 0.96 higher (0.32 to 1.61 higher) NR very low1,2,6
Hospital-LOS The mean Hospital- LOS ranged across control groups from 8.5 to 32.5 days The mean Hospital-LOS in the intervention groups was 0.56 higher (0.03 Lower to 1.15 higher) NR very low1,2,7
MODS/MOF 284 per 1000 363 per 1000 OR 1.44 very low1,8
(348 to 379) (1.35 to 1.54)
  1. *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio.
  2. LOS, length of stay; ED time, time spent in the emergency department; NR, not reported.
  3. 1There were significant differences in baseline characteristics between the two groups (WBCT and NWBCT).
  4. 2In most of the studies, patients who underwent WBCT had higher levels of injury severity score (ISS).
  5. 3There was evidence of heterogeneity between studies (Chi2 = 541.42, df = 4, P < 0.00001; I2 = 99%).
  6. 4The pooled effect size of weighted mean difference = –27.58 min; 95% CI –43.04 to –12.12; p = 0.0005)
  7. 5we found a significant heterogeneity among the studies (Chi2 = 63.81, df = 5, P < 0.00001; I2 = 92%).
  8. 6The test of heterogeneity showed significant differences in each study (Chi2 = 33.05, df = 4, P < 0.00001; I2 = 88%).
  9. 7The amount of studies (total length of hospital stay was described) is too little.
  10. 8OR was 1.44 [95% CI 1.35-1.54], p < 0.00001.