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Prehospital risk factors of mortality and impaired consciousness after severe traumatic brain injury: an epidemiological study



Severe traumatic brain injury (TBI) is a significant health concern and a major burden for society. The period between trauma event and hospital admission in an emergency department (ED) could be a determinant for secondary brain injury and early survival. The aim was to investigate the relationship between prehospital factors associated with secondary brain injury (arterial hypotension, hypoxemia, hypothermia) and the outcomes of mortality and impaired consciousness of survivors at 14 days.


A multicenter, prospective cohort study was performed in dedicated trauma centres of Switzerland. Adults with severe TBI (Abbreviated Injury Scale score of head region (HAIS) >3) were included. Main outcome measures were death and impaired consciousness (Glasgow Coma Scale (GCS) ≤13) at 14 days. The associations between risk factors and outcome were assessed with univariate and multivariate regression models.


589 patients were included, median age was 55 years (IQR 33, 70). The median GCS in ED was 4 (IQR 3-14), with abnormal pupil reaction in 167 patients (29.2%). Median ISS was 25 (IQR 21, 34). Three hundred seven patients sustained their TBI from falls (52.1%) and 190 from a road traffic accidents (32.3%). Median time from Out-of-hospital Emergency Medical Service (OHEMS) departure on scene to arrival in ED was 50 minutes (IQR 37-72); 451 patients had a direct admission (76.6%). Prehospital hypotension was observed in 24 (4.1%) patients, hypoxemia in 73 (12.6%) patients and hypothermia in 146 (24.8%). Prehospital hypotension and hypothermia (apart of age and trauma severity) was associated with mortality. Prehospital hypoxemia (apart of trauma severity) was associated with impaired consciousness; indirect admission was a protective factor.


Mortality and impaired consciousness at 14 days do not have the same prehospital risk factors; prehospital hypotension and hypothermia is associated with mortality, and prehospital hypoxemia with impaired consciousness.


Severe traumatic brain injury (TBI) is a worldwide health concern and a major burden for society[1, 2] related to long hospital stays, persistence of physical handicap and neuro-psychological alterations, and a long period of working inability if there is any return to work at all[3]. It is one of the main contributors of life-year loss due to its high mortality of 30 to 70% in a younger population[4, 5]. It also accounts for about two thirds of all trauma related fatalities[4, 6]. Severe TBI has a high mortality rate in the early period and survivors present many major, in-hospital complications[7]. Surviving patients after severe TBI suffer also from a lower life expectancy than the general population[8].

The pathophysiology of severe TBI can be divided into primary and secondary brain injury[9]. Primary injury results from the direct, physical brain trauma with tissue distortion, shearing, vascular injury, and cell destruction probably related to rotational acceleration and deceleration inertial forces[10]. Secondary brain injury is related to destructive inflammation and biochemical changes[11, 12]. Secondary injury onsets within minutes of primary injury, may last for several days and contributes to final outcome[13, 14]. Primary and secondary brain injuries induce cerebral oedema and bleeding. Factors associated with secondary brain injury are arterial hypotension, hypoxemia and hypothermia; these adverse events are associated with increased mortality and poor outcome[15].

Out-of-hospital emergency medical systems (OHEMS) should ensure the shortest delay possible between the sustainment of the trauma and the patient’s admission to a trauma center and decrease the factors associated with secondary brain injury[16]. Despite the potential benefits of early interventions such as oxygen administration with or without orotracheal intubation and mechanical ventilation, or fluid administration and heat preservation, the evidence for their efficacy is controversial[9]. In clinical practice it is difficult to estimate secondary brain injury related to prolonged prehospital periods, prehospital hypotension, prehospital hypoxemia, or prehospital hypothermia. Death[17] and impaired consciousness of survivors[18] several days after the TBI can be used as clinical surrogates of early secondary brain injury[1921]. Survival with regained consciousness with execution of commands several days after the TBI can be considered as an early, clinical surrogate of neural network re-functioning[22] and is a predictor of the long term functional outcome[23].

The aim of this study was to investigate the relationship between prehospital factors associated with secondary brain injury and the outcomes of mortality and impaired consciousness at fourteen days.


Design of study

We conducted a prospective epidemiological cohort study with follow-up of patients with severe TBI from the time of accident until 14 days or earlier death. This study is a part of the Swiss National Cohort of severe TBI entitled “Patient-relevant Endpoints after Brain Injury from Traumatic Accidents” (PEBITA; Demographic data of this study has been published recently[24].

Switzerland has a surface of 41'285 km2 and a population of 7.95 Mio (2011). Half of the population lives in and around larger cities (3.7 Mio). The country’s population density is 193 inhabitants per km2. About 130 OHEMS (104 certified OHEMS) are available [3.1 (2.5)/ 1’000 km2 or 1.6 (1.3)/100’000 population]. Eighteen helicopter EMS cover the area of the country [0.4/1’000 km2 or 0.2/100’000 population]. Twelve governmental defined trauma centers with dedicated emergency physicians manage patients with severe TBI together with neurosurgeons and anesthesiologists based on local clinical pathways.

The study was approved by the ethics committees of the participating trauma centers (Ethics committee of Geneva, protocol NAC 07-013, approval: 7.5.2007). As a result of their neurological condition, patients were unable to give informed consent before enrolment. The local study coordinators contacted their legal representatives (proxies) to inform them of the study within 14 days following the TBI. Both patients and/or proxies received detailed written information on the study and were asked for consent. In the case of withdrawal, further follow-up was discontinued. Complying with a patient’s request, the collected data was removed from the database and destroyed.

Included patients

We included patients ≥16 years having sustained severe TBI from both blunt and penetrating trauma in Switzerland. Severe TBI was defined by an Abbreviated Injury Scale score of head region (HAIS) of more than 3; AIS is a six point score of trauma severity[25]. HAIS was assessed based on the diagnoses that neurosurgeons or radiologists in charge and established after computer tomography imaging of the head. The worst CT scan in the first 24 hours was assessed using a standardized data sheet based on the HAIS and Marshall classification[26]. Patients who died before neurosurgical or radiological diagnosis were included if the history of trauma and trauma signs of severe head injury were documented by the OHEMS. Patients with unclear brain trauma history (for instance, comatose patients found on a public area without observation by bystanders) or no signs of brain trauma (for instance, fatal multi-trauma patients with abdominal and thoracic injuries without visual injuries to the head) were excluded. We excluded patients without body temperature documentation at hospital admission.

The GCS was not used as an inclusion criterion due to its large inter-rater variability, in particular, in the emergency setting[27]. In a pilot study we observed that of 118 potentially eligible participants 12 could not be included since the inclusion criterion “initial GCS <9 without sedation” was not met[5]. However, these patients had injuries compatible with severe TBI according to the AIS criterion.

Outcome measures

  • Mortality at 14 days.

  • Impaired consciousness (estimated with the GCS) at 14 days; impaired consciousness was defined as GCS ≤13 and consciousness was defined as GCS 14 and 15.

Potential predictors

  1. i.

    Patients’ characteristics: age

  2. ii.

    Initial neuro-physiological variables: Glasgow Coma Scale (GCS; comatose patients were defined as presenting a GCS <9), pupil reaction

  3. iii.

    Trauma mechanism: road traffic accidents, falls and other mechanisms. Blunt/penetrating trauma was not investigated in details because more than 95% of injuries were blunt trauma. Results on the few penetrating trauma were reported separately.

  4. iv.

    Trauma severity: The Injury Severity Score (ISS) within the 24 hours following the injury event was used which included concomitant injuries. [28]

  5. v.

    Prehosptial time, e.g. the period of time from OHEMS departure from the scene of injury to its arrival in the emergency department (ED) in trauma centre and direct or indirect admission to trauma centre were collected.

  6. vi.

    Prehospital arterial hypotension was defined as systolic blood pressure <90 mmHg measured at any time point until hospital admission including the hospital arrival value.

  7. vii.

    Prehospital hypoxia was defined as a pulse oximeter oxygen saturation <90% at any time point until hospital admission including hospital arrival value.

  8. viii.

    Prehospital hypothermia was defined as a temperature ≤35.0°C at hospital admission.


Qualitative variables such as sex, pupil reaction, HAIS, mechanism of accident, hypotension, hypoxemia, hypothermic and direct or indirect admission to ED were summarized using percentages for the entire cohort. Quantitative variables such as age, GCS in ED, ISS, and time from OHEMS departure on scene to arrival in ED in trauma centre were described by their median and interquartile ranges (IQRs) (25th to 75th percentile) for the entire cohort.

Descriptive statistics were conducted for the following subgroups: Survivors versus non-survivors at 14 days and impaired consciousness (GCS ≤13) for survivors versus consciousness (GCS 14 and 15) for survivors at 14 days. Differences between two groups were assessed by non-parametric Wilcoxon t-tests with an alpha threshold of 5% for quantitative variables, and by χ2 tests with an alpha threshold of 5% for qualitative variables.

In order to evaluate the association between prehospital risk factors and outcome at 14 days we performed a Cox regression (survival) or a logistic regression (impaired consciousness). Age, GCS in ED, pupil reaction, ISS, mechanism of accident, arterial hypotension, hypoxemia, hypothermic, prehospital time and direct or indirect admission to ED were first included in a univariate Cox regression or logistic regression. All variables with p <0.200 in the univariate model were entered in a multivariate model.

All statistical analyses were performed using STATA Release 12 · 0 (Stata Statistical Software: Release 12 · 0, Stata Corporation, College Station, USA).


Demographic data

Five hundred and eighty-nine patients were included (Figure 1). The median age of the patients was 55 years (IQR 33-70). One hundred forty six patients (24.8%) were women. The median GCS on-scene was 9 (IQR 4-14), and 4 (IQR 3-14) in the ED. In the ED, 343 patients (59.0%) had a GCS <9. Abnormal pupil reaction on scene was observed in 128 patients (25.8%), and in 167 patients (29.2%) in the ED. The majority of patients sustained a blunt trauma (562 out of 589; 95.4%). Two hundred forty-seven patients out of 589 had a HAIS of 4 (41.9%) and 330 a HAIS of 5 (56.0%). The median ISS was 25 (IQR 21-34). Three hundred and seven patients sustained their TBI from a fall (52.1%) and 190 from a road traffic accidents (32.3%). Twenty-seven patients with a penetrating trauma (4.6%) were younger (median 35; IQR 26-56) with a lower GCS in the ED (median 3; IQR 3-4) and a higher ISS (median 29; IQR 25-41).

Figure 1
figure 1

Flow chart of enrolled and included patients with severe TBI.

The median time from OHEMS departure on scene to its arrival in the ED was 50 minutes (IQR 37-72). Four hundred fifty-one patients had a direct admission (76.6%); the median time was 46 minutes (IQR 35-58). One hundred and thirty eight patients had an indirect admission (23.4%); the median time was 198 minutes (IQR 143-297). Prehospital arterial hypotension was observed in 24 (4.1%) patients. Prehospital hypoxemia was observed in 73 (12.6%) patients. Prehospital hypothermia was observed in 146 (24.8%) patients.

Five hundred forty-three patients were managed by an OHEMS [of those, 209 with a helicopter OHEMS (38.5%)]; 44 patients were admitted to the trauma centre without OHEMS (7.5%). Two thirds of the patients (317 out of 467 patients, where this data was available) were treated by a certified prehospital physician. Two hundred forty-five patients (45.6%) had a prehospital intubation and 481 had prehospital intravenous fluids (84.4%).

Outcome at 14 days

During 3 839 person-days of follow-up, there were 159 deaths. Survival rate was 73.0% (430 out of 589 patients) at 14 days (Table 1); survival rate of patients with penetrating trauma was 40.7% (9 out of 27).

Table 1 Description of surviving and not surviving patients at 14 days

The median GCS of survivors at 14 days was 15 (IQR 13-15). Impaired consciousness at 14 days was observed in 104 out of 411 survivors (25.3%; missing: 19) (Table 2). An abnormal pupil reaction was observed at 14 days in 20 out of 430 survivors.

Table 2 Description of surviving patients with impaired consciousness (GCS <14) and regained consciousness (GCS14 and 15) at 14 days

Prehospital risk factors for mortality at 14 days

In the univariate model, 7 risk factors were associated with a higher risk of death at 14 days (age, GCS <9 in ED, abnormal pupil reaction, ISS ≥25, prehospital arterial hypotension, prehospital hypoxemia and prehospital hypothermia; Table 3); not associated were trauma mechanisms, prehospital time, and type of admission.

Table 3 Risk factors of death at 14 days

In the multivariate model, 6 risk factors were independently associated with a higher risk of death at 14 days: age, GCS <9 in ED, abnormal pupil reaction, ISS ≥25, prehospital arterial hypotension and hypothermia.

Prehospital risk factors for impaired consciousness at 14 days

In the univariate model 5 risk factors were associated with a higher risk of impaired consciousness at 14 days (GCS < 9 in ED, abnormal pupil reaction, ISS ≥25, prehospital hypoxemia and prehospital hypothermia; Table 4); 3 protective factors (age, trauma mechanism other than road traffic accidents, indirect admission) were associated with a lower risk of impaired consciousness at 14 days; not associated were prehospital hypotension, and prehospital time.

Table 4 Risk and protective factors of impaired consciousness at 14 days (N = 411, 19 patients without evaluation)

In the multivariate model, 3 risk factors were independently associated with a higher risk of impaired consciousness: GCS <9 in ED, ISS ≥25 and prehospital hypoxemia. One protective factor (indirect admission) was associated with a lower risk of impaired consciousness.


Main results

One main result of this study was that arterial hypotension and hypothermia are prehospital risk factors for mortality. Another main result was that hypoxemia is a prehospital risk factor for impaired consciousness for survivors at 14 days. In our cohort with a mature emergency medical system, prehospital time was not identified as risk or protective factors for mortality or impaired consciousness of survivors.

Comparison with earlier studies

Our finding confirms that arterial hypotension is a prehospital risk factor for mortality. In a recent study in the Netherlands including 339 adult patients with a CT-confirmed severe TBI and a GCS ≤8 (mean age: 44 years) similar risks factors including prehospital hypotension were observed; independent predictors were age, ISS, disturbed pupillary reflex and arterial hypotension[17]. A further similarity to our study was that hypoxemia could not be identified as an independent prehospital risk factor for mortality at 14 days; however, prehospital time and hypothermia were not investigated. In an older study Schreiber et al. identified arterial hypotension in ED as an independent risk factor, together with intracranial hypertension, for hospital mortality in 368 adult patients with a HAIS 5 (mean age: 35 years)[29]. In contrast, using the Glasgow Outcome Scale (GOS) at 6 months as outcome, McHugh et al. identified arterial hypotension, hypoxemia and hypothermia prior to or on admission to hospital as independent risk factors for poor outcome based on a meta-analyses of individual data of 7 randomized controlled trials[15].

We observed an association between prehospital hypothermia and mortality. Similarly, a retrospective cohort study based on the Los Angeles Trauma Database observed that in moderate to severe TBI, there was an association between prehospital hypothermia and mortality; however and in contrast to this study, the number of patients with hypothermia was small (n = 44) which decreased the validity of the observed result[30]. Our result is also in line with the meta-analysis of McHugh et al[15].

In our prospective observational study in Switzerland with a well-organized trauma system and a high number of older patients we could not confirm the association between direct admission and mortality. This is in contrast to an analysis of the online database called TBI-trac in New York State including 1123 patients (with GCS ≤8) which observed an association between indirect admission and mortality[31]. The divergence between the studies may be related to the following facts: first, the case-mix was younger (mean age 36 years) with probably more road traffic accidents and, second, the longer times for indirect admission (mean 4.5 h) in the New York State study.

Impaired consciousness 14 days after trauma of survivors is rarely used as outcome and its utilization may extend previous observations. In contrast to the initial period reaching several days after severe TBI, an evaluation with the GCS is probably less biased by interrater variability and changes over time[27]. In our cohort impaired consciousness of survivors was independently associated with unconsciousness in the ED, a higher degree of injury and prehospital hypoxemia. A similar association was observed in a retrospective study including 1547 patients with a HAIS ≥3 and mean age of 41 years where the average PO2 <100 mmHg in the first 24 hours was associated with a worse discharge GCS score[19]. Interestingly, these authors observed the same association with hyperoxia (>200 mmHg in the first 24 hours) suggesting that the therapeutic safety range of oxygen in severe TBI is small.

Clinical relevance

Isolated severe TBI without bleeding is associated with arterial hypertension related to sympathetic nervous system activation[20, 21]; therefore, arterial hypotension is probably most often associated with considerable hypovolemia related to a potentially invisible additional trauma with bleeding contributing to the risk of death. Based on statistical models, it has been proposed that systolic blood pressure should be 110 mmHg to avoid low cerebral perfusion pressure-associated mortality[32]. In another model Butcher et al. proposed an optimal systolic blood pressure of 135 mmHg for best outcome[33]. However, based on a retrospective cohort study using the large American College of Surgeons National Trauma Data Bank, it was hypothesized that prehospital intravenous administration of fluids was independently associated with mortality[34]; the authors discouraged the use of intravenous fluids and proposed a concept of hypotensive resuscitation. Furthermore, there is evidence, based on a randomized controlled trial, that administration of prehospital hypertonic resuscitation in patients with severe TBI and hypotension is not effective[35]. It is possible that a subgroup of patients suffering from severe TBI with hypotension, perhaps older patients, may benefit of fluid and low continuous doses of norepinephrine; however, such treatment protocols have to tested in randomized trials.

Prehospital hypothermia is major challenge for northern countries and countries with high mountains in particular, in winter seasons. Furthermore, hypothermia may be aggravated in intubated and sedated patients on scene. However, only very few concepts of prehospital active warming have been tested[36]. Further research including outcome data are needed for this promising therapeutic approach.

Prehospital hypoxemia after severe TBI may be related to aspiration or to supplementary thorax injuries. Severe chest trauma and aspiration related to blood or gastric content may occur very early after the trauma[37, 38], even before OHEMS are on scene and before “protective” intubation or drainage can be performed. Together with absence of evidence[39], the potential benefit of prehospital intubation and ventilation with positive pressure is controversial. It is possible that a subgroup of patients suffering from severe TBI, with hypoxemia at scene of injury or long distances to a trauma center, may benefit from prehospital intubation, ventilation avoiding hyper- and hypocarbia, and limited administration of oxygen.

Strength of the study

This cohort study with adults suffering from severe TBI is a prospective study with precisely defined outcomes at 14 days with few lost in the follow-up, including different centers in a high income country with a mature trauma system. The data were analyzed with validated methods. Therefore, our findings can be generalized to countries with a similar situation and may be considered as a best-case scenario.

Limitations of the study

Our results are associations and, therefore, may not be causative. We can’t exclude that some patients with severe TBI were not admitted to a trauma centre and only received treatment in a primary-care hospital against the legal regulation. Patient selection for this cohort was performed by local collaborators from the participating trauma centers, and therefore, some inter-rater variability cannot be excluded; however, data pertaining to inclusion criteria was scrutinized by the data management centre and, in case of a discrepancy, all inclusion criteria were re-checked with the local collaborators. Temperature measurement was not performed in all patients with severe TBI; therefore, we can’t exclude a minor bias of our results including only patients with temperature measurement.


Prehospital hypotension and hypothermia were associated with short term mortality after serve TBI. Prehospital hypoxemia was associated with impaired consciousness at 14 days.


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The authors thank Ezra Bottequin for English language editing.

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Correspondence to Bernhard Walder.

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Competing interests

The authors declare no conflicts of interest. B.W. received support from the Swiss Accident Company and the Bangerter-Rhyner Foundation, Switzerland, for this project. The founding agencies had no role in the preparation, review or approval of the manuscript.

Authors’ contributions

MZ, GH, BW were responsible for conception, design, acquisition of data, and successful realization of the multi-centre study. ST and BW did the literature research. C.D, GH BW analyzed the data and interpreted the results in collaboration with ST and MZ. ST wrote the first draft of the manuscript. All authors critically revised the manuscript and approved the final version.

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Tohme, S., Delhumeau, C., Zuercher, M. et al. Prehospital risk factors of mortality and impaired consciousness after severe traumatic brain injury: an epidemiological study. Scand J Trauma Resusc Emerg Med 22, 1 (2014).

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