- Original research
- Open Access
Treatment of penetrating trauma of the extremities: ten years’ experience at a dutch level 1 trauma center
© Waes et al.; licensee BioMed Central Ltd. 2013
- Received: 14 September 2012
- Accepted: 3 January 2013
- Published: 14 January 2013
A selective non-operative management (SNOM) has found to be an adequate and safe strategy to assess and treat patients suffering from penetrating trauma of the extremities (PTE). With this SNOM comes a strategy in which adjuvant investigations or interventions are not routinely performed, but based on physical examination only.
All subsequent patients presented with PTE at a Dutch level I trauma center from October 2000 to June 2011 were included in this study. In-hospital and long-term outcome was analysed in the light of assessment of these patients according to the SNOM protocol.
A total of 668 patients (88.2% male; 33.8% gunshot wounds) with PTE presented at the Emergency Department of a level 1 traumacenter, of whom 156 were admitted for surgical treatment or observation. Overall, 22 (14%) patients that were admitted underwent exploration of the extremity for vascular injury. After conservative observation, two (1.5%) patients needed an intervention to treat (late onset) vascular complications. Other long-term extremity related complications were loss of function or other deformity (n = 9) due to missed nerve injury, including 2 patients with peroneal nerve injury caused by delayed compartment syndrome treatment.
A SNOM protocol for initial assessment and treatment of PTE is feasible and safe. Clinical examination of the injured extremity is a reliable diagnostic 'tool' for excluding vascular injury. Repeated assessments for nerve injuries are important as these are the ones that are frequently missed and result in long-term disability. Level of evidence: II / III, retrospective prognostic observational cohort study Key words Penetrating trauma, extremity, vascular injury, complications.
- Nerve Injury
- Compute Tomography Angiography
- Vascular Injury
- Compartment Syndrome
- Acute Compartment Syndrome
Penetrating trauma of the extremities (PTE) is considered a difficult injury to manage because artery and nerve injuries can be serious and may significantly impair outcome of the patient. PTE accounts for about 50% of penetrating trauma. Despite possible (long-term) complications, overall survival is very high[1, 2]. Nevertheless, the low incidence of this kind of trauma in Western Europe makes it difficult for trauma surgeons to gain experience in its management.
Signs of arterial injury
Absent distal pulses or ischemia
Expanding or pulsatile hematoma
Bruit or thrill
Subjective reduced or unequal pulses
Large non-pulsatile hematoma
Orthopedic injuries carrying a high index of suspicion of vascular injury
History of large hemorrhage on trauma scene
The present study was undertaken to assess SNOM in relation to long-term outcome and complications.
Patients and methods
All patients presented with PTE at a single Dutch level I trauma center from October 2000 to June 2011 were included in this study. Data regarding age, gender, mechanism of injury, type of injury (i.e. vascular, orthopaedic, or nerve), anatomical location and concomitant injuries, clinical manifestations and vital parameters, indications for additional investigations, and treatment strategy of all patients were collected and analyzed in the light of patient’s long-term outcome.
Appropriate approval of the local ethical review board was obtained prior to inclusion of patients into the trauma database. Due to the retrospective and anonymous nature of the database no further approval was deemed necessary by the ethical review board.
Hemodynamically unstable patients were immediately transferred to the operating room. In actively bleeding patients hemorrhage control was attempted by using a tourniquet followed by Foley catheter balloon tamponade (FCBT). If hemorrhage control was not established, surgical exploration of the injured extremity had to follow immediately. If hemorrhage was controlled by FCBT, angiography or CTA was indicated after removal of an eventual tourniquet, in order to detect major arterial injury. If positive, patients should still be transferred to the operating room or treated by endovascular stenting or coiling. Without any arterial injury deemed in need of surgical or radiological interventional (RI) treatment, the patient should be observed for 24–48 hours, after which the Foley catheter was removed in the operating room. In case of re-bleeding, surgical intervention was performed.
A total of 668 patients (88.2% male; 33.8% GSWs) with PTE presented at the Emergency Department during the study period. After initial assessment, 512 patients were discharged home from the Emergency Department as the type and severity of their injury did not necessitate admission for observation or intervention. None of these patients returned to the hospital with late onset complications due to PTE.
Demographics of 156 patients admitted with penetrating extremity injury
Sex ratio (M:F)
Age, years (median; range)
Penetrating extremity injury
Stab wound (female)
Gunshot wound (female)
Computed tomography angiography
Concomitant penetrating injury 2
Indications for and results of vascular investigations
Indication for investigation
CTA (n = 16)
Absent or diminished pulses
Foley catheter balloon catheter
Proximity to major vessels
Indications for surgical intervention
Indication for emergency exploration
Active hemorrhage or shock
Vascular injury found at CTA
Indication for early surgery
Vascular injury found at CTA
Removal of bullet
Fasciotomy of the lower leg
(Long-term) complications that were initially missed or had severe consequences
-Brain-injury due to exsanguination (n = 2)
-Femoral nerve injury
-Arterio-venous fistula after femoral a. repair
-Brachial plexus lesion
Limp/ weakness arm
-Median nerve lesion
Ape hand deformity
-Ulnar nerve injury (n = 2)
Paraesthesia and weakness
-Leg length difference after femur fracture
-Sciatic nerve injury after femoral a. repair
Leg pain and foot weakness
-Hip joint disarticulation after femoral a. injury and femur fracture
-Peroneal nerve injury after compartment syndrome
compartment syndrome after popliteal a. repair (n = 2)
-False aneurysm popliteal a.
-Erysipelas foot due to bullet
-Ulnar nerve injury
Two patients (both SW) died of diffuse axonal injury and post anoxic encephalopathy after exsanguination due to penetrating chest and extremity injury. Besides, the complications mentioned above, long-term extremity related complications were loss of function or other deformity (n = 9) including two patients with peroneal nerve injury caused by delayed compartment syndrome treatment, late onset infection and severe wound healing problems resulting in hip exarticulation (n = 1; combined injury of femoral artery and proximal femur).
In the Netherlands, as in the rest of Western Europe, the incidence of penetrating injury is rather low. Due to the low incidence it is not possible for a trauma surgeon to get extensive experience with the management and treatment of this kind of trauma, causing obscurity, disagreement in diagnostic and treatment options, and an insufficient or incomplete management of this trauma patient. All together, inexperience in assessment of patients with PTE might increase the risk of mistakes and may hamper outcome.
In trauma centers that treat a higher number of patients with penetrating trauma, SNOM is becoming more and more accepted. SNOM is based on clinical examination and additional investigations (on indication). Together they have shown to be a reliable indicator of clinically significant injury, with a sensitivity and specificity of 99% and a negative predictive value of 99%[6, 10]. The management protocol for assessing and treating patients with PTE is based essentially on hemodynamic status, together with a thorough physical examination. Adjuvant CTA is only indicated based on hard and subtle signs of vascular injury found during clinical assessment in hemodynamically stabilized patients. CTA is a reliable and accurate investigation with a sensitivity and specificity of 95% and 100% respectively, a positive predictive value of 100% and a negative predictive value of 98%[11–13]. Therefore CTA is more and more becoming the diagnostic tool of choice during initial evaluation of stable patients with suspected vascular injury, including patients after PTE[13, 14]. The combination of FCBT and CTA could also diminish the rate of negative explorations and iatrogenic injuries. In one patient an actively bleeding groin was successfully controlled by FCBT. Subsequent CTA revealed no indication for surgical exploration, and after two days the catheter was removed without rebleeding.
In the present study the SNOM protocol for penetrating extremity injury was correctly executed with good persistence. Only four out of 124 admitted patients with no signs of vascular injury still underwent CTA. None showed signs of vascular lesions, and all four were successfully treated conservatively. Vascular observational management after PTE was applied in 86% of admitted patients without (n = 126) or after CTA (n = 8) assessment. During follow up only one (0.7%) of the patients who were conservatively treated and observed returned with symptoms of a false aneurysm several months later. This indicates that initial conservative management (or SNOM) of patients with PTE is feasible and safe.
Although the majority of patients presented at the Emergency Department with supposed PTE are not seriously injured and can be discharged after physical examination and treatment of wounds, up to a quarter of patients should be admitted for observation, additional investigations or surgical treatment. The total surgical treatment rate of the latter group was 24% (22 vascular injuries, five fractures, 10 exclusively neural injuries), indicating that PTE should be considered a serious trauma which requires intensive and thorough assessment of the extremities. PTE is frequently accompanied by other penetrating injuries (in this study in 43% of cases), that possibly needs to be managed first or distracts the physician’s attention away from the injuries of the extremities. Eventually missed or even delayed assessment of PTE may significantly impair outcome of the patient[15, 16].
In the present study, seven patients (5%) who were treated conservatively showed symptoms of nerve injury that were missed during the initial hospital stay. Although the larger part of nerve injuries cannot be treated, it is important to recognize these injuries at initial assessment, in order to adequately inform patients and provide supportive treatment. These are important factors in the rehabilitation process after penetrating trauma, especially for patients with prolonged or definitive impairment of the extremity.
Not only is it important to recognize nerve injury at initial assessment, it is of vital importance to prevent nerve injury in a later stage of treatment. Of all 12 patients that underwent primary vascular repair, only two underwent fasciotomy during the same vascular-reconstructive operation in order to prevent compartment syndrome. In two (20%) patients who had not undergone fasciotomy, compartment syndrome after revascularisation of the leg was diagnosed too late, resulting in persistent peroneal nerve injury. In other words, a patient sustaining PTE should not only be intensively reassessed several times during conservative treatment, but also after surgical treatment, not only for vascular injury, but nerve injury as well. Besides, pre-emptive fasciotomy is advised, in patients sustaining a combination of arterial and venous injury, multiple or complex fractures and an ischemia time longer than six hours[18, 19], as continuous compartment pressure-monitoring is not reliable. Blood flow should be restored as soon as possible by using a shunt. After initial shunting, fractures should be rigidly stabilized using external fixation devices, in order to perform definitive vascular repair with a tension free (venous) interposition graft. Since these repairs usually take a fair amount of time, there is a serious threat of compartment syndrome after revascularisation. Therefore, a pre-emptive fasciotomy is highly recommended.
In summary, the low failure rate in this study validates the SNOM protocol for initial management of PTE. Clinical examination of the injured extremity is a reliable diagnostic approach for excluding vascular injury. It is important to assess for possible nerve injuries, both pre- and post operatively, as these injuries are frequently missed and might result in long-term disability.
- Doody O, Given MF, Lyon SM: Extremities–indications and techniques for treatment of extremity vascular injuries. Injury. 2008, 39: 1295-303. 10.1016/j.injury.2008.02.043.View ArticlePubMedGoogle Scholar
- Manthey DE, Nicks BA: Penetrating trauma to the extremity. J Emerg Med. 2008, 34: 187-93. 10.1016/j.jemermed.2007.03.038.View ArticlePubMedGoogle Scholar
- Dennis JW, Frykberg ER, Veldenz HC, Huffman S, Menawat SS: Validation of nonoperative management of occult vascular injuries and accuracy of physical examination alone in penetrating extremity trauma: 5- to 10-year follow-up. J Trauma. 1998, 44: 243-52. 10.1097/00005373-199802000-00001.View ArticlePubMedGoogle Scholar
- Dragas M, Davidovic L, Kostic D, Markovic M, Pejkic S, Ille T, Ilic N, Koncar I: Upper extremity arterial injuries: factors influencing treatment outcome. Injury. 2009, 40: 815-9. 10.1016/j.injury.2008.08.012.View ArticlePubMedGoogle Scholar
- Stone WM, Fowl RJ, Money SR: Upper extremity trauma: current trends in management. J Cardiovasc Surg. 2007, 48: 551-5.Google Scholar
- Van Waes OJF, Navsaria PH, Verschuren RCM, Vroon LC, Van Lieshout EMM, Halm JA, Nicol AJ, Vermeulen J, Frykberg ER, Dennis JW, Bishop K, Laneve L, Alexander RH: Management of penetrating injuries of the upper extremities. (submitted)7. The reliability of physical examination in the evaluation of penetrating extremity trauma for vascular injury: results at one year. J Trauma. 1991, 31: 502-511. 10.1097/00005373-199104000-00009.View ArticleGoogle Scholar
- Keen JD, Dunne PM, Keen RR, Langer BG: Proximity arteriography: cost effectiveness in asymptomatic penetrating extremity trauma. J Vasc Interv Radiol. 2001, 12: 813-2. 10.1016/S1051-0443(07)61505-X.View ArticlePubMedGoogle Scholar
- Corballis B, Nitowski L: Prim Care. Advanced trauma life support. 1986, 13: 33-44.Google Scholar
- Peng PD, Spain DA, Tataria M, Hellinger JC, Rubin GD, Brundage SI: CT angiography effectively evaluates extremity vascular trauma. Am Surg. 2008, 74: 103-7.PubMedGoogle Scholar
- Wallin D, Yaghoubian A, Rosing D, Walot I, Chauvapun J, de Virgilio C: Computed tomographic angiography as the primary diagnostic modality in penetrating lower extremity vascular injuries: a level I trauma experience. Ann Vasc Surg. 2011, 25: 620-3. 10.1016/j.avsg.2011.02.022.View ArticlePubMedGoogle Scholar
- Soto JA, Múnera F, Cardoso N, Guarín O, Medina S: Diagnostic performance of helical CT angiography in trauma to large arteries of the extremities. J Comput Assist Tomogr. 1999, 23: 188-96. 10.1097/00004728-199903000-00005.View ArticlePubMedGoogle Scholar
- Seamon MJ, Smoger D, Torres DM, Pathak AS, Gaughan JP, Santora TA, Cohen G, Goldberg AJ: A prospective validation of a current practice: the detection of extremity vascular injury with CT angiography. J Trauma. 2009, 67: 238-43. 10.1097/TA.0b013e3181a51bf9.View ArticlePubMedGoogle Scholar
- Halvorson JJ, Anz A, Langfitt M, Deonanan JK, Scott A, Teasdall RD, Carroll EA: Vascular injury associated with extremity trauma: initial diagnosis and management. J Am Acad Orthop Surg. 2011, 19: 495-504.PubMedGoogle Scholar
- Hafez HM, Woolgar J, Robbs JV: Lower extremity arterial injury: results of 550 cases and review of risk factors associated with limb loss. J Vasc Surg. 2001, 33: 1212-9. 10.1067/mva.2001.113982.View ArticlePubMedGoogle Scholar
- Richardson JD, Vitale GC, Flint LM: Penetrating arterial trauma. Analysis of missed vascular injuries. Arch Surg. 1987, 122: 678-83. 10.1001/archsurg.1987.01400180060011.View ArticlePubMedGoogle Scholar
- Jaquet JB, Kalmijn S, Kuypers PD, Hofman A, Passchier J, Hovius SE: Early psychological stress after forearm nerve injuries: a predictor for long-term functional outcome and return to productivity. Ann Plast Surg. 2002, 49: 82-90. 10.1097/00000637-200207000-00013.View ArticlePubMedGoogle Scholar
- Farber A, Tan TW, Hamburg NM, Kalish JA, Joglar F, Onigman T, Rybin D, Doros G, Eberhardt RT: Early fasciotomy in patients with extremity vascular injury is associated with decreased risk of adverse limb outcomes: A review of the National Trauma Data Bank. Injury. 2011, 28: Epub ahead of printGoogle Scholar
- Zaraca F, Ponzoni A, Stringari C, Ebner JA, Giovannetti R, Ebner H: Lower extremity traumatic vascular injury at a level II trauma center: an analysis of limb loss risk factors and outcomes. Minerva Chir. 2011, 66: 397-407.PubMedGoogle Scholar
- Desai P, Audige L, Suk M: Combined orthopedic and vascular lower extremity injuries: sequence of care and outcomes. Am J Orthop (Belle Mead NJ). 2012, 41: 182-6.Google Scholar
- Gifford SM, Eliason JL, Clouse WD, Spencer JR, Burkhardt GE, Propper BW, Dixon PS, Zarzabal LA, Gelfond JA, Rasmussen TE: Early versus delayed restoration of flow with temporary vascular shunt reduces circulating markers of injury in a porcine model. J Trauma. 2009, 67: 259-65. 10.1097/TA.0b013e3181a5e99b.View ArticlePubMedGoogle Scholar
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