Global Health Estimates 2020: Deaths by cause, age, sex, by country and by region, 2000-2019 Geneva: World Health Organization; 2020 https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-leading-causes-of-death.
World Health Organization. Injury: a leading cause of the global burden of disease. Geneva: World Health Organization; 1999 1999. Contract No.: WHO/HSC/PVI/99.11.
Drake SA, Holcomb JB, Yang YJ, Thetford C, Myers L, Brock M, et al. Establishing a regional trauma preventable/potentially preventable death rate. Annal Surg. 2020;271(2):375–82.
Article
Google Scholar
Eastridge BJ, Mabry RL, Seguin P, Cantrell J, Tops T, Uribe P, et al. Death on the battlefield (2001–2011): implications for the future of combat casualty care. J Trauma Acute Care Surg. 2012;73(6 Suppl 6):S431–7.
Article
PubMed
Google Scholar
Kobusingye OC, Hyder AA, Bishai D, Joshipura M, Hicks ER, Mock C. Emergency Medical Services. Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, et al., editors. Washington, D.C.: Oxford University Press; 2006.
Laytin AD, Debebe F. The burden of injury in low-income and middle-income countries: knowing what we know, recognising what we don’t know. Emerg Med J. 2019;36(7):387–8.
PubMed
Google Scholar
World Health Organization. Injuries and violence: the facts. Geneva: World Health Organization; 2010.
Google Scholar
Crandall M, Sharp D, Unger E, Straus D, Brasel K, Hsia R, et al. Trauma deserts: distance from a trauma center, transport times, and mortality from gunshot wounds in Chicago. Am J Public Health. 2013;103(6):1103–9.
Article
PubMed
PubMed Central
Google Scholar
Gonzalez RP, Cummings GR, Phelan HA, Mulekar MS, Rodning CB. Does increased emergency medical services prehospital time affect patient mortality in rural motor vehicle crashes? A statewide analysis. Am J Surg. 2009;197(1):30–4.
Article
PubMed
Google Scholar
Groenewald P, Bradshaw D, Daniels J, Matzopoulos R, Bourne DE, Blease D, et al. Cause of death and premature mortality in Cape Town, 2001–2006. Cape Town South African Medical Research Council; 2008.
Norman R, Matzopoulos R, Groenewald P, Bradshaw D. The high burden of injuries in South Africa. Bull World Health Organ. 2007;85(9):695–702.
Article
PubMed
PubMed Central
Google Scholar
Haagsma JA, Graetz N, Bolliger I, Naghavi M, Higashi H, Mullany EC, et al. The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013. Inj Prev. 2016;22(1):3–18.
Article
PubMed
Google Scholar
Schuurman N, Cinnamon J, Walker BB, Fawcett V, Nicol A, Hameed SM, et al. Intentional injury and violence in Cape Town, South Africa: an epidemiological analysis of trauma admissions data. Glob Health Action. 2015;8:27016.
Article
PubMed
Google Scholar
Eastridge BJ, Hardin M, Cantrell J, Oetjen-Gerdes L, Zubko T, Mallak C, et al. Died of wounds on the battlefield: causation and implications for improving combat casualty care. J Trauma Acute Care Surg. 2011;71(1):S4–8.
Article
Google Scholar
Mazuchowski E, Kotwal R, Janak J, Howard J, Harcke H, Montgomery H, et al. Mortality review of US special operations command battle-injured fatalities. J Trauma Acute Care Surg. 2020;88(5):686–95.
Article
PubMed
Google Scholar
Hampton DA, Fabricant LJ, Differding J, Diggs B, Underwood S, De La Cruz D, et al. Prehospital intravenous fluid is associated with increased survival in trauma patients. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S9-15.
Article
PubMed
PubMed Central
Google Scholar
Schreiber MA, Meier EN, Tisherman SA, Kerby JD, Newgard CD, Brasel K, et al. A controlled resuscitation strategy is feasible and safe in hypotensive trauma patients: results of a prospective randomized pilot trial. J Trauma Acute Care Surg. 2015;78(4):687–97.
Article
PubMed
PubMed Central
Google Scholar
Schauer SG, Naylor JF, April MD, Thronson EE, Maddry JK, Becker TE, et al. The First 30 Months Experience in the Non-Doctrinal Operation Inherent Resolve Medical Theater. Mil Med. 2018.
Harmsen AMK, Giannakopoulos GF, Moerbeek PR, Jansma EP, Bonjer HJ, Bloemers FW. The influence of prehospital time on trauma patients outcome: a systematic review. Injury. 2015;46(4):602–9.
Article
CAS
PubMed
Google Scholar
Kotwal RS, Mazuchowski EL, Janak JC, Howard JT, Harcke HT, Holcomb JB, et al. United States military fatalities during Operation New Dawn. J Trauma Acute Care Surg. 2021;91(2):375–83.
Article
PubMed
Google Scholar
Gomes E, Araujo R, Carneiro A, Dias C, Costa-Pereira A, Lecky FE. The importance of pre-trauma centre treatment of life-threatening events on the mortality of patients transferred with severe trauma. Resuscitation. 2010;81(4):440–5.
Article
PubMed
Google Scholar
Gonzalez RP, Cummings G, Mulekar M, Rodning CB. Increased mortality in rural vehicular trauma: identifying contributing factors through data linkage. J Trauma. 2006;61(2):404–9.
Article
PubMed
Google Scholar
Dinh MM, Bein K, Roncal S, Byrne CM, Petchell J, Brennan J. Redefining the golden hour for severe head injury in an urban setting: The effect of prehospital arrival times on patient outcomes. Injury. 2012;44(5):606–10.
Article
PubMed
Google Scholar
Swaroop M, Straus DC, Agubuzu O, Esposito TJ, Schermer CR, Crandall ML. Pre-hospital transport times and survival for Hypotensive patients with penetrating thoracic trauma. J Emerg Trauma Shock. 2013;6(1):16–20.
Article
PubMed
PubMed Central
Google Scholar
Murad MK, Larsen S, Husum H. Prehospital trauma care reduces mortality. Ten-year results from a time-cohort and trauma audit study in Iraq. Scand J Trauma Resusc Emerg Med. 2012;20:13.
Article
PubMed
PubMed Central
Google Scholar
Ibrahim NA, Ajani AWO, Mustafa IA, Balogun RA, Oludara MA, Idowu OE, et al. Road traffic injury in Lagos, Nigeria: assessing prehospital care. Prehosp Disaster Med. 2017;32(4):424–30.
Article
PubMed
Google Scholar
Whitaker J, O’Donohoe N, Denning M, Poenaru D, Guadagno E, Leather AJM, et al. Assessing trauma care systems in low-income and middle-income countries: a systematic review and evidence synthesis mapping the Three Delays framework to injury health system assessments. BMJ Glob Health. 2021. https://doi.org/10.1136/bmjgh-2020-004324.
Article
PubMed
PubMed Central
Google Scholar
Keenan S, Riesberg JC. Prolonged field care: beyond the “Golden Hour.” Wilderness Environ Med. 2017;28(2S):S135–9.
Article
PubMed
Google Scholar
Carius B, Davis WT, Linscomb CD, Escandon MA, Rodriguez D, Uhaa N, et al. An analysis of US Africa command area of operations military medical transportations, 2008–2018. AfJEM. 2020;10(1):13–6.
PubMed
Google Scholar
Schauer SG, April MD, Naylor JF, Maddry JK, Keen DE, Cunningham CW, et al. A descriptive analysis of casualties evacuated from the Africa area of operations. AfJEM. 2019;9(Suppl):S43–6.
PubMed
Google Scholar
Mabry RL, DeLorenzo R. Challenges to improving combat casualty survival on the battlefield. Mil Med. 2014;179(5):477–82.
Article
PubMed
Google Scholar
Mould-Millman N-K, Ginde A, Bebarta V, Schauer S, Cunningham C, Moore E, et al. Establishing the Epidemiology and Outcomes of Combat-Relevant Prolonged Trauma Care: a Prospective Multicenter Prehospital Pilot Study in South Africa. University of Colorado at Denver Department of Defense Congressionally Directed Medical Research Programs; 2019–2021.
Mould-Millman N-K, Ginde AA, Bebarta VS, Schauer S, Cunningham C, Becker TE, et al. Epidemiology and Outcomes of Combat-Relevant Prolonged Trauma Care: a Prospective Multicenter Prehospital Study in South Africa. University of Colorado at Denver: Department of Defense, Defense Medical Research and Development Program; 2020–2024.
Mock C, Joshipura M, Arreola-Risa C, Quansah R. An estimate of the number of lives that could be saved through improvements in trauma care globally. World J Surg. 2012;36(5):959–63.
Article
PubMed
Google Scholar
Stellenbosch University, Tygerberg Hospital. Tygerberg Academic Hospital Cape Town, South Africa http://www.sunorthopaedics.com/tygerberg-hospital.html.
Mahoney SH, Steyn E, Lategan H. Informing future policy for trauma prevention: The effect of the COVID-19 ‘National state of disaster lockdown’ on the trauma burden of a tertiary trauma centre in the Western Cape of South Africa. AfJEM. 2021;11(3):361–5.
PubMed
PubMed Central
Google Scholar
Western Cape Government Health. Tygerberg Hospital: Vision, Mission and Values Cape Town, South Africa: Western Cape Government Health; https://www.westerncape.gov.za/assets/departments/health/tygerberg_hospital_information_pamphlet_-_2016.pdf.
Bateman C. The smell of coffee, blood and disinfectant. S Afr Med J. 2014;104:727–9.
Article
PubMed
Google Scholar
Barolsky V. Violence in Khayelitsha: finding a way out 2014 [cited 2021 03/31/2021]. http://www.hsrc.ac.za/en/review/hsrc-review-sept-2014/violence-in-khayelitsha.
Ahiable E, Lahri SA, Bruijns S. Describing the categories of people that contribute to an Emergency Centre crowd at Khayelitsha hospital, Western Cape, South Africa. AfJEM. 2017;7(2):68–73.
PubMed
PubMed Central
Google Scholar
Allgaier RL, Laflamme L, Wallis LA. Operational demands on pre-hospital emergency care for burn injuries in a middle-income setting: a study in the Western Cape, South Africa. Int J Emerg Med. 2017;10(1):2.
Article
PubMed
PubMed Central
Google Scholar
Mould-Millman NK, Dixon J, Lamp A, de Vries S, Beaty B, Finck L, et al. A single-site pilot implementation of a novel trauma training program for prehospital providers in a resource-limited setting. Pilot Feasibility Stud. 2019;5:143.
Article
PubMed
PubMed Central
Google Scholar
Western Cape Government Health. Healthcare 2030: The Road to Wellness 2014 https://www.westerncape.gov.za/assets/departments/health/healthcare2030.pdf.
Department of Defense Trauma Registry Data Dictionary. 2019. DoD Trauma Registry Data Dictionary.
2021. NEMSIS Data Dictionary.
2021. National Trauma Data Standard Data Dictionary.
Pan-Asian Trauma Outcomes Study Clinical Research Network. Pan-Asian Trauma Outcomes Study Data Dictionary. 2016 http://lems.re.kr/eng/wp-content/uploads/sites/2/2016/09/PATOS-data-dictionary-1.4_part1.pdf.
World Health Organization. WHO International Registry for Trauma and Emergency Care. 2019 https://www.who.int/emergencycare/irtec/en/.
Bedard AF, Mata LV, Dymond C, Moreira F, Dixon J, Schauer SG, et al. A scoping review of worldwide studies evaluating the effects of prehospital time on trauma outcomes. Int J Emerg Med. 2020;13(1):64.
Article
PubMed
PubMed Central
Google Scholar
Twomey M, Wallis LA, Thompson ML, Myers JE. The South African Triage Scale (adult version) provides reliable acuity ratings. Int Emerg Nurs. 2012;20(3):142–50.
Article
PubMed
Google Scholar
Holcomb JB, Moore EE, Sperry JL, Jansen JO, Schreiber MA, Del Junco DJ, et al. Evidence-based and clinically relevant outcomes for hemorrhage control trauma trials. Ann Surg. 2021;273(3):395–401.
Article
PubMed
Google Scholar
Mould-Millman N-K, Mata L, Schauer SG, Dixon J, Keenan S, Holcomb JB, et al. Defining Combat-Relevant Endpoints for Early Trauma Resuscitation Research in a Resource-Constrained Civilian Setting. Med J (Ft Sam Houst Tex). 2021(Military Emergency Medicine special edition):3–14.
Hutchings L, Watkinson P, Young JD, Willett K. Defining multiple organ failure after major trauma: a comparison of the denver, sequential organ failure assessment, and marshall scoring systems. J Trauma Acute Care Surg. 2017;82(3):534–41.
Article
PubMed
PubMed Central
Google Scholar
Frohlich M, Wafaisade A, Mansuri A, Koenen P, Probst C, Maegele M, et al. Which score should be used for posttraumatic multiple organ failure? - Comparison of the MODS, Denver- and SOFA- Scores. Scand J Trauma Resusc Emerg Med. 2016;24(1):130.
Article
PubMed
PubMed Central
Google Scholar
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.
Article
PubMed
Google Scholar
Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L, et al. The REDCap consortium: building an international community of software platform partners. J Biomed Inform. 2019;95:103208.
Article
PubMed
PubMed Central
Google Scholar
Wolkewitz M, Allignol A, Harbarth S, de Angelis G, Schumacher M, Beyersmann J. Time-dependent study entries and exposures in cohort studies can easily be sources of different and avoidable types of bias. J Clin Epidemiol. 2012;65(11):1171–80.
Article
PubMed
Google Scholar
Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data. 2nd ed. Hoboken, N.J: J. Wiley; 2002.
Book
Google Scholar
Klein J, Moeschberger M. Survival Analysis Techniques for Censored and Truncated Data. 2nd ed. Dietz K, Gail M, Krickeberg K, Samet J, Tsiatis A, editors. New York, NY: Springer; 2003.
Putter H, Fiocco M, Geskus RB. Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 2007;26:2389–430.
Article
CAS
PubMed
Google Scholar
McCulloch C. Joint modelling of mixed outcome types using latent variables. Stat Methods Med Res. 2008;17(1):53–73.
Article
PubMed
Google Scholar
Liu L, Wolfe R, Huang X. Shared frailty models for recurrent events and a terminal event. Biometrics. 2004;60:747–56.
Article
PubMed
Google Scholar
Frangakis CE, Rubin DB, An MW, MacKenzie E. Principal stratification designs to estimate input data missing due to death. Biometrics. 2007;63(3):641–9 (discussion 50-62).
Article
PubMed
Google Scholar
Hayden D, Pauler DK, Schoenfeld D. An estimator for treatment comparisons among survivors in randomized trials. Biometrics. 2005;61(1):305–10.
Article
PubMed
Google Scholar
Rubin DB. Causal inference through potential outcomes and principal stratification: application to studies with “censoring” due to death. Stat Sci. 2006;21(3):299–309.
Article
Google Scholar
Zhang JNL, Rubin DB. Estimation of causal effects via principal stratification when some outcomes are truncated by “death.” J Educ Behav Stat. 2003;28(4):353–68.
Article
Google Scholar
McCullagh P, Nelder JA. Generalized Linear Models. 2nd ed. Boca Raton: Routledge; 2019.
Book
Google Scholar
Hernán MA, Robins JM. Estimating causal effects from epidemiological data. J Epidemiol Commun Health. 2006;60(7):578–86.
Article
Google Scholar
Robins JM, Hernán MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology. 2000;11(5):550–60.
Article
CAS
PubMed
Google Scholar
Little R, Rubin D. Statistical Analysis with Missing Data. 3rd ed. Hoboken, New Jersey: Wiley; 2019.
Google Scholar
Vogel JA, Seleno N, Hopkins E, Colwell CB, Gravitz C, Haukoos JS. Denver ED trauma organ failure score outperforms traditional methods of risk stratification in trauma. Am J Emerg Med. 2015;33(10):1440–4.
Article
PubMed
PubMed Central
Google Scholar
Cameron PA, Gabbe BJ, Cooper DJ, Walker T, Judson R, McNeil J. A statewide system of trauma care in Victoria: effect on patient survival. Med J Aust. 2008;189(10):546–50.
Article
PubMed
Google Scholar
Mock CN, Adzotor KE, Conklin E, Denno DM, Jurkovich GJ. Trauma outcomes in the rural developing world: comparison with an urban level I trauma center. J Trauma. 1993;35(4):518–23.
Article
CAS
PubMed
Google Scholar
Gabbe BJ, Simpson PM, Sutherland AM, Wolfe R, Fitzgerald MC, Judson R, et al. Improved functional outcomes for major trauma patients in a regionalized, inclusive trauma system. Ann Surg. 2012;255(6):1009–15.
Article
PubMed
Google Scholar
Kotwal RS, Howard JT, Orman JA, Tarpey BW, Bailey JA, Champion HR, et al. The effect of a golden hour policy on the morbidity and mortality of combat casualties. JAMA Surg. 2016;151(1):15–24.
Article
PubMed
Google Scholar
Chichom Mefire A, Etoundi Mballa GA, Azabji Kenfack M, Juillard C, Stevens K. Hospital-based injury data from level III institution in Cameroon: retrospective analysis of the present registration system. Injury. 2013;44(1):139–43.
Article
PubMed
Google Scholar