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Septic shock: ECMO beyond ARDS? Introducing the Simon two-stage protocol when randomisation is considered unethical
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine volume 28, Article number: 22 (2020)
One of the great disappointments during the past decades has been the failure to convert advances in our understanding of the biologic features of sepsis into new therapies. Although numerous multicenter, randomized controlled trials have been conducted in the last 30 years, no reduction of septic shock mortality was achieved  .  Taking together available evidence suggests that no sepsis specific therapies are available until today, although a roadmap on the way to a specific septic shock therapy might be on the horizon   including artificial intelligence . .
Interestingly, in the Surviving Sepsis Campaign guidelines  ECMO (Extra Corporal Membrane Oxygenation) is not mentioned as a treatment option.
ECMO has been a standard treatment for cardiac and respiraory failure in neonates and children for decades,  in contrast to adults where the debate about the benefit of ECMO still is ongoing.
A systematic review and meta-analysis showed that the use of veno-arterial life support (ECLS) in cardiac arrest was associated with a higher survival (NNT [number needed to treat] 7.7) as well as a better neurological outcome, in the setting of cardiogenic shock there was a higher survival with ECLS compared with IABP (NNT 3) .
Since even the efficacy of venovenous extracorporal membrane oxygenation with severe respiratory distress syndrome (ARDS) has been disputed controversially until today a randomized controlled trial comparing vv-ECMO with conventional treatment was initiated with the results published recently (EOLIA trial) . The main causes of ARDS were bacterial pneumonia in 45% and viral pneumonia in 18% of the patients, 78% of the patients had severe sepsis or septic shock. Primary end point was mortality at 60 days. No difference was found in the initial intention-to-treat analysis. However, 35 patients (28%) in the control group crossed over to ECMO. In fact, reanalysis including crossover patients as treatment failure and comparing death/crossover to ECMO of the control group vs death in the ECMO group showed a 23% lower mortality in the ECMO group (NNT 5).
In addition, Robert Bartlett in an editorial in CCM argued that the difference of the intention to treat vs treatment failure analysis results from 35 patients in the conventional care group who crossed over to the ECMO group as rescue treatment when conventional care was failing. Accordingly, the study had become a study of early versus late ECMO. Therefore, the EOLIA trial had shown that ECMO should be used promptly when high-risk criteria are met, rather than as late rescue therapy when death from ARDS or multiple organ failure is imminent .
What about the use of va-ECMO in the treatment of septic shock? To date, ECMO is suggested only as rescue therapy  and only observational case series with some promising results have been published (for overview see Table 1). However, the impression is not unequivocal. Thus, in a commentary discussing the results of Ro et al. the question is asked whether ECMO therapy in septic shock is a heroic futility or not . The authors come to the conclusion that in this study more than half of the patients had liver cirrhosis, including post-liver transplantation and the patient cohort was derived from the years 2005 through 2012; both factors could adversely affect outcomes. On the contrary, the results of a just recently published observational study  are very promising with a hospitality mortality of just 10% in cytotoxic cardiac failure and 30% in distributive shock.
In this situation where randomized controlled trials are considered unethical, Bartlett suggests that the matched pairs method is the best study design for evaluation of life support systems in acute fatal illness in a high risk population early .
For patients with septic shock we suggest another approach – the Simon  two-stage non-randomized method including only patients with septic shock (Sepsis-3 definition ;) resulting from secondary peritonitis.
The Simon protocol is a Phase 2 design. According to Evrard et al. “Phase 2 is a completely underutilized tool in surgery that could raise the level of scientific reporting. The threshold for efficacy and nonefficacy is defined and with statistical power (risks a and b), the cohort size is calculated (usually, between 30 and 60 patients). The use of interim stopping rules allows reduction of the required number of patients (e.g., Simon design)” .
We use the following assumptions: ECMO treatment is considered as poor (P0) if mortality is above 55% and as sufficient (P1) if it is below 40% with a two-sided alpha of 0.05 and a beta of 0.20.
Inclusion criteria: Overcoming the criticism of sepsis trials in the past, namely heterogeneity of patient populations (ie mixing medical and surgical patients), we are only studying septic shock due to secondary peritonitis, a group with a reported very high mortality; age: 18–70 years, norepinephrine > 0,5 μg/kg/min despite adequate volume substitution (30 ml/kg) within the first 12 h, serum lactate > 2 mmol/l, duration of septic shock < 24 h (ie ECMO is initiated as an early and not as a rescue therapy); Exclusion criteria: Septic shock due to other sources than the abdomen, peripheral arterial occlusive disease excluding femoral/axillary vessel cannulation; duration of septic shock > 24 h; patient waiver concerning life support measures.
The ECMO route is peripheral with an initial flow ≥4.5 l/min and norepinephrine should be reduced at least to below norepinephrine > 0,5 μg/kg/min. The standard protocol in patients with VA-ECMO is to adjust the blood flow of the machine and the dosage of norepinephrine in order to achieve a mean arterial pressure of at least 65 mmHg. After achieving this MAP norepinephrine is tapered if possible, to below 0.1 μg/kg/min. In addition, inferior vena cava saturation is monitored continuously with a target saturation above 55. Finally, transthoracic echocardiography is performed daily when norepinephrine dosage is above 0.5 μg/kg/min.
CRRT will be used while on ECMO (default CRRT is SLED, it might be possible to use the oxygenator for connecting the dialysis machine, depending on the arterial and internal pressure of the oxygenator, if too high, a separate dialysis catheter has to be established). Distal arterial limb perfusion is used in every patient by a 6F sheat strengthened by wire. Filters for removing cytokines are not allowed.
The design with a moderate cluster effect results in the following study conditions: Include 40 patients at a first stage and reject the approach if 16 or less patients survive (and 24 more die).
Otherwise, the second stage will be recruited until overall n = 79 patients are included. The treatment approach will be rejected if overall 43 or less patients survive (i. e., 36 or more patients die).
This study design follows important recommendations: First, it is not a randomized trial (ie avoiding ethical issues,  ; and second, the defined patient population has a high mortality risk and avoids heterogeneity. Moreover, the Simon approach leads rapidly to results in a small number of patients in which a minimum of data collection could be provided .
In conclusion in answering the question ‘Septic shock – ECMO beyond ARDS?’ we strongly believe, against the background of quite discrepant results of observational studies (see Table 1 )that va-ECMO should be studied as outlined in the above protocol with emphasis on early ECMO (ie not as rescue ECMO) when failure of conventional therapy for septic shock is evident: norepinephrine > 0,5 μg/kg/min despite adequate volume substitution (30 ml/kg) within the first 12 h and serum lactate > 2 mmol/l.
Availability of data and materials
extra corporal membrane oxygenation
Acute respiratory distress syndrome
number needed to treat
renal replacement therapy
sustained low efficiency dialysis
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Buia, A., Hopf, HB., Herrmann, E. et al. Septic shock: ECMO beyond ARDS? Introducing the Simon two-stage protocol when randomisation is considered unethical. Scand J Trauma Resusc Emerg Med 28, 22 (2020). https://doi.org/10.1186/s13049-020-0714-3