Chan AW, Tetzlaff JM, Gotzsche PC, Altman DG, Mann H, Berlin JA, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013;346:e7586.
Article
PubMed Central
PubMed
Google Scholar
Handley AJ, Koster R, Monsieurs K, Perkins GD, Davies S, Bossaert L. European Resuscitation Council Guidelines for Resuscitation 2005: Section 2. Adult basic life support and use of automated external defibrillators. Resuscitation. 2005;67:S7–23.
Article
PubMed
Google Scholar
Grubb NR, Fox KAA, Elton RA. In-hospital mortality after out-of-hospital cardiac arrest. Lancet. 1995;346:417–21.
Article
CAS
PubMed
Google Scholar
Lindner TW, Langorgen J, Sunde K, Larsen AI, Kvaloy JT, Heltne JK, et al. Factors predicting the use of therapeutic hypothermia and survival in unconscious out-of-hospital cardiac arrest patients admitted to the ICU. Crit Care. 2013;17:R147.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rosomoff HL, Holaday DA. Cerebral Blood Flow and Cerebral Oxygen Consumption During Hypothermia. Am J Physiol. 1954;179:85–8.
CAS
PubMed
Google Scholar
Safar P, Xiao F, Radovsky A, Tanigawa K, Ebmeyer U, Bircher N, et al. Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke. 1996;27:105–13.
Article
CAS
PubMed
Google Scholar
The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–56.
Article
Google Scholar
Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. New Engl J Med. 2002;346:557–63.
Article
PubMed
Google Scholar
Arrich J, Holzer M, Havel C, Mullner M, Herkner H. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev. 2012;9:,CD004128.
PubMed
Google Scholar
Peberdy M, Callaway C, Neumar R, Geocadin R, Zimmerman J, Donnino M, et al. Part 9: post-cardiac arrest care. American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010;2010:S768–86.
Article
Google Scholar
Nolan JP, Soar J, Zideman DA, Biarent D, Bossaert LL, Deakin C, et al. European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary. Resuscitation. 2010;81:1219–76.
Article
PubMed
Google Scholar
Laurent I, Adrie C, Vinsonneau C, Cariou A, Chiche J-D, Ohanessian A, et al. High-Volume Hemofiltration After Out-of-Hospital Cardiac Arrest: A Randomized Study. J Am Coll Cardiol. 2005;46:432–7.
Article
PubMed
Google Scholar
Hachimi-Idrissi S, Corne L, Ebinger G, Michotte Y, Huyghens L. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation. 2001;51:275–81.
Article
CAS
PubMed
Google Scholar
Kim YM, Yim HW, Jeong SH, Klem ML, Callaway CW. Does therapeutic hypothermia benefit adult cardiac arrest patients presenting with non-shockable initial rhythms? A systematic review and meta-analysis of randomized and non-randomized studies. Resuscitation. 2012;83:188–96.
Article
PubMed
Google Scholar
Dumas F, Grimaldi D, Zuber B, Fichet J, Charpentier J, Pene F, et al. Is Hypothermia After Cardiac Arrest Effective in Both Shockable and Nonshockable Patients? Insights From a Large Registry. Circulation. 2011;123:877–86.
Article
PubMed
Google Scholar
Vaahersalo J, Hiltunen P, Tiainen M, Oksanen T, Kaukonen KM, Kurola J, et al. Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study. Intensive Care Med. 2013;39:826–37.
Article
PubMed
Google Scholar
Rd P, Jung C, Purle S, Lauten A, Yilmaz A, Surber R, et al. Survival does not improve when therapeutic hypothermia is added to post-cardiac arrest care. Resuscitation. 2011;82:1168–73.
Article
Google Scholar
Storm C, Nee J, Roser M, Jorres A, Hasper D. Mild hypothermia treatment in patients resuscitated from non-shockable cardiac arrest. Emerg Med J. 2012;29:100–3.
Article
PubMed
Google Scholar
Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med. 2013;369:2197–206.
Article
CAS
PubMed
Google Scholar
Frydland M, Kjaergaard J, Erlinge D, Wanscher M, Nielsen N, Pellis T, et al. Target temperature management of 33°C AND 36°C in patients with out-of-hospital cardiac arrest with initial non-shockable rhythm. A TTM sub-study. Resuscitation. 2015.
Testori C, Sterz F, Behringer W, Haugk M, Uray T, Zeiner A, et al. Mild therapeutic hypothermia is associated with favourable outcome in patients after cardiac arrest with non-shockable rhythms. Resuscitation. 2011;82:1162–7.
Article
PubMed
Google Scholar
Horburger D, Testori C, Sterz F, Herkner H, Krizanac D, Uray T, et al. Mild therapeutic hypothermia improves outcomes compared with normothermia in cardiac-arrest patients-a retrospective chart review. Crit Care Med. 2012, Publish Ahead of Print:10.1097/CCM.1090b1013e31825333cf.
Lundbye JB, Rai M, Ramu B, Hosseini-Khalili A, Li D, Slim HB, et al. Therapeutic hypothermia is associated with improved neurologic outcome and survival in cardiac arrest survivors of non-shockable rhythms. Resuscitation. 2012;83:202–7.
Article
PubMed
Google Scholar
Larsen JM, Ravkilde J. Acute coronary angiography in patients resuscitated from out-of-hospital cardiac arrest–a systematic review and meta-analysis. Resuscitation. 2012;83:1427–33.
Article
PubMed
Google Scholar
Wissenberg M, Lippert FK, Folke F, Weeke P, Hansen CM, Christensen EF, et al. Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA. 2013;310:1377–84.
Article
CAS
PubMed
Google Scholar
Soholm H, Hassager C, Lippert F, Winther-Jensen M, Hartvig-Thomsen J, Friberg H, et al. Factors Associated With Successful Resuscitation After Out-of-Hospital Cardiac Arrest and Temporal Trends in Survival and Comorbidity. Ann Emerg Med. 2014.
Lindner TW, Soreide E, Nilsen OB, Torunn MW, Lossius HM. Good outcome in every fourth resuscitation attempt is achievable–an Utstein template report from the Stavanger region. Resuscitation. 2011;82:1508–13.
Article
PubMed
Google Scholar
Dumas F, White L, Stubbs BA, Cariou A, Rea TD. Long-Term Prognosis Following Resuscitation From Out of Hospital Cardiac Arrest: Role of Percutaneous Coronary Intervention and Therapeutic Hypothermia. J Am Coll Cardiol. 2012;60:21–7.
Article
PubMed
Google Scholar
Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 2012;307:1161–8.
Article
CAS
PubMed
Google Scholar
Atiksawedparit P, Rattanasiri S, McEvoy M, Graham CA, Sittichanbuncha Y, Thakkinstian A. Effects of prehospital adrenaline administration on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis. Crit Care. 2014;18:463.
Article
PubMed Central
PubMed
Google Scholar
Goto Y, Maeda T, Goto Y. Effects of prehospital epinephrine during out-of-hospital cardiac arrest with initial non-shockable rhythm: an observational cohort study. Crit Care. 2013;17:R188.
Article
PubMed Central
PubMed
Google Scholar
Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2007:CD003311.
Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, et al. Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes. New Engl Jo Med. 2014;371:140–9.
Article
CAS
Google Scholar
Wee JH, Park KN, Oh SH, Youn CS, Kim HJ, Choi SP. Outcome analysis of cardiac arrest due to hanging injury. Am J Emerg Med. 2012;30:690–4.
Article
PubMed
Google Scholar
Borgquist O, Friberg H. Therapeutic hypothermia for comatose survivors after near-hanging. A retrospective analysis. Resuscitation. 2009;80:210–2.
Article
PubMed
Google Scholar
Baldursdottir S, Sigvaldason K, Karason S, Valsson F, Sigurdsson GH. Induced hypothermia in comatose survivors of asphyxia: a case series of 14 consecutive cases. Acta Anaesthesiol Scand. 2010;54:821–6.
Article
CAS
PubMed
Google Scholar
Sadaka F. Therapeutic hypothermia for brain injury from near hanging: review of the literature. Therapeutic Hypothermia Temp Manag. 2013;3:13–6.
Article
Google Scholar
Geurts M, Macleod MR, Kollmar R, Kremer PH, van der Worp HB. Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis. Crit Care Med. 2014;42:231–42.
Article
PubMed
Google Scholar
Perbet S, Mongardon N, Dumas F, Bruel C, Lemiale V, Mourvillier B, et al. Early onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. Am J Respir Crit Care Med. 2011;184:1048–54.
Article
PubMed
Google Scholar
Legriel S, Hilly-Ginoux J, Resche-Rigon M, Merceron S, Pinoteau J, Henry-Lagarrigue M, et al. Prognostic value of electrographic postanoxic status epilepticus in comatose cardiac-arrest survivors in the therapeutic hypothermia era. Resuscitation. 2013;84:343–50.
Article
PubMed
Google Scholar
Fairchild KD, Singh IS, Patel S, Drysdale BE, Viscardi RM, Hester L, et al. Hypothermia prolongs activation of NF-KB and augments generation of inflammatory cytokines. Am J Physiol Cell Physiol. 2004;287:C422–31.
Article
CAS
PubMed
Google Scholar
Leary M, Grossestreuer AV, Iannacone S, Gonzalez M, Shofer FS, Povey C, et al. Pyrexia and neurologic outcomes after therapeutic hypothermia for cardiac arrest. Resuscitation. 2013;84:1056–61.
Article
PubMed
Google Scholar
Bro-Jeppesen J, Hassager C, Wanscher M, Soholm H, Thomsen JH, Lippert FK, et al. Post-hypothermia fever is associated with increased mortality after out-of-hospital cardiac arrest. Resuscitation. 2013;84:1734–40.
Article
PubMed
Google Scholar
Annborn M, Bro-Jeppesen J, Nielsen N, Ullen S, Kjaergaard J, Hassager C, et al. The association of targeted temperature management at 33 and 36 degrees C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest: a post hoc analysis of the Target Temperature Management trial. Intensive Care Med. 2014;40:1210–9.
Article
PubMed
Google Scholar
Deye N, Arrich J, Cariou A. To cool or not to cool non-shockable cardiac arrest patients: it is time for randomized controlled trials. Intensive Care Med. 2013;39:966–9.
Article
PubMed
Google Scholar
Pittl U, Schratter A, Desch S, Diosteanu R, Lehmann D, Demmin K, et al. Invasive versus non-invasive cooling after in- and out-of-hospital cardiac arrest: a randomized trial. Clin Res Cardiol. 2013;102:607–14.
Article
PubMed
Google Scholar
Tomte O, Draegni T, Mangschau A, Jacobsen D, Auestad B, Sunde K. A comparison of intravascular and surface cooling techniques in comatose cardiac arrest survivors. Crit Care Med. 2011;39:443–9.
Article
PubMed
Google Scholar
Kim F, Olsufka M, Carlbom D, Deem S, Longstreth Jr WT, Hanrahan M, et al. Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest. Circulation. 2005;112:715–9.
Article
PubMed
Google Scholar
Kim F, Olsufka M, Longstreth WT, Maynard C, Carlbom D, Deem S, et al. Pilot Randomized Clinical Trial of Prehospital Induction of Mild Hypothermia in Out-of-Hospital Cardiac Arrest Patients With a Rapid Infusion of 4°C Normal Saline. Circulation. 2007;115:3064–70.
Article
PubMed
Google Scholar
Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, et al. Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest. Crit Care Med. 2011;40:747–53.
Article
Google Scholar
Poblete B, Romand JA, Pichard C, Konig P, Suter PM. Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients. Br J Anaesth. 1997;78:123–7.
Article
CAS
PubMed
Google Scholar
Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. 2003;289:2983–91.
Article
PubMed
Google Scholar
Lascarrou JB, Le Gouge A, Dimet J, Lacherade JC, Martin-Lefevre L, Fiancette M, et al. Neuromuscular blockade during therapeutic hypothermia after cardiac arrest: observational study of neurological and infectious outcomes. Resuscitation. 2014;85:1257–62.
Article
PubMed
Google Scholar
May T, Seder DB, Fraser GL, Tu C, McCrum B, Lucas L, et al. Association of the Bedside Shivering Assessment Scale and derived EMG power during therapeutic hypothermia in survivors of cardiac arrest. Resuscitation. 2011;82:1100–3.
Article
PubMed
Google Scholar
Badjatia N, Strongilis E, Gordon E, Prescutti M, Fernandez L, Fernandez A, et al. Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale. Stroke. 2008;39:3242–7.
Article
PubMed
Google Scholar
Voicu S, Deye N, Malissin I, Vigue B, Brun PY, Haik W, et al. Influence of alpha-stat and pH-stat blood gas management strategies on cerebral blood flow and oxygenation in patients treated with therapeutic hypothermia after out-of-hospital cardiac arrest: a crossover study. Crit Care Med. 2014;42:1849–61.
Article
CAS
PubMed
Google Scholar
Cronberg T, Horn J, Kuiper MA, Friberg H, Nielsen N. A structured approach to neurologic prognostication in clinical cardiac arrest trials. Scand J Trauma Resusc Emerg Med. 2013;21:45.
Article
PubMed Central
PubMed
Google Scholar
Daubin C, Bornstain C, Graftieaux J, Thirion M, Régnier B. Avis de la CE-SRLF sur la démarche de prise de décision de limitation ou d’arrêt des thérapeutiques chez l’adulte en coma postanoxique après un arrêt cardiaque. Réanimation. 2012;21:637–44.
Article
Google Scholar
Jennett B, Bond M. Assessment of outcome after severe brain damage: a pratical scale. Lancet. 1975;305:480–4.
Article
Google Scholar
Cummins R, Chamberlain D, Abramson N, Allen M, Baskett P, Becker L, et al. Recommended guidelines for uniform reporting of data from out-of- hospital cardiac arrest: the Utstein Style. A statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Circulation. 1991;84:960–75.
Article
CAS
PubMed
Google Scholar
Stiell IG, Nesbitt LP, Nichol G, Maloney J, Dreyer J, Beaudoin T, et al. Comparison of the Cerebral Performance Category Score and the Health Utilities Index for Survivors of Cardiac Arrest. Ann Emerg Med. 2009;53:241–8. e241.
Article
PubMed
Google Scholar
Fayol P, Carriere H, Habonimana D, Preux PM, Dumond JJ. French version of structured interviews for the Glasgow Outcome Scale: guidelines and first studies of validation. Annales de readaptation et de medecine physique: revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique. 2004;47:142–56.
Article
CAS
Google Scholar
Moulaert VR, Wachelder EM, Verbunt JA, Wade DT, van Heugten CM. Determinants of quality of life in survivors of cardiac arrest. J Rehabil Med. 2010;42:553–8.
Article
PubMed
Google Scholar
Keller SD, Ware Jr JE, Bentler PM, Aaronson NK, Alonso J, Apolone G, et al. Use of structural equation modeling to test the construct validity of the SF-36 Health Survey in ten countries: results from the IQOLA Project. International Quality of Life Assessment. J Clin Epidemiol. 1998;51:1179–88.
Article
CAS
PubMed
Google Scholar
Katz S, Downs TD, Cash HR, Grotz RC. Progress in development of the index of ADL. Gerontologist. 1970;10:20–30.
Article
CAS
PubMed
Google Scholar
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA. 1963;185:914–9.
Article
CAS
PubMed
Google Scholar
Della Pietra GL, Savio K, Oddone E, Reggiani M, Monaco F, Leone MA. Validity and reliability of the Barthel index administered by telephone. Stroke. 2011;42:2077–9.
Article
PubMed
Google Scholar
Longstreth WT, Nichol G, Van Ottingham L, Hallstrom AP. Two simple questions to assess neurologic outcomes at 3 months after out-of-hospital cardiac arrest: Experience from the Public Access Defibrillation Trial. Resuscitation. 2010;81:530–3.
Article
PubMed Central
PubMed
Google Scholar
Roccaforte WH, Burke WJ, Bayer BL, Wengel SP. Validation of a telephone version of the mini-mental state examination. J Am Geriatr Soc. 1992;40:697–702.
CAS
PubMed
Google Scholar
Horowitz M, Wilner N, Alvarez W. Impact of Event Scale: a measure of subjective stress. Psychosom Med. 1979;41:209–18.
Article
CAS
PubMed
Google Scholar
Contentin L, Ehrmann S, Giraudeau B. Heterogeneity in the definition of mechanical ventilation duration and ventilator-free days. Am J Respir Crit Care Med. 2014;189:998–1002.
Article
PubMed
Google Scholar
Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.
Article
PubMed Central
PubMed
Google Scholar
Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I Introduction and design. Br J Cancer. 1976;34:585–612.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kagawa E, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Kurisu S, et al. Who benefits most from mild therapeutic hypothermia in coronary intervention era? A retrospective and propensity-matched study. Crit Care. 2010;14:R155.
Article
PubMed Central
PubMed
Google Scholar
Drennan IR, Lin S, Thorpe KE, Morrison LJ. The effect of time to defibrillation and targeted temperature management on functional survival after out-of-hospital cardiac arrest. Resuscitation. 2014;85(11):1623–8.
Article
PubMed
Google Scholar
Testori C, Sterz F, Holzer M, Losert H, Arrich J, Herkner H, et al. The beneficial effect of mild therapeutic hypothermia depends on the time of complete circulatory standstill in patients with cardiac arrest. Resuscitation. 2012;83:596–601.
Article
PubMed
Google Scholar
Lopez-de-Sa E, Rey JR, Armada E, Salinas P, Viana-Tejedor A, Espinosa-Garcia S, et al. Hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing 2 levels of target temperature. Circulation. 2012;126:2826–33.
Article
PubMed
Google Scholar
Winters SA, Wolf KH, Kettinger SA, Seif EK, Jones JS, Bacon-Baguley T. Assessment of risk factors for post-rewarming “rebound hyperthermia” in cardiac arrest patients undergoing therapeutic hypothermia. Resuscitation. 2013;84:1245–9.
Article
CAS
PubMed
Google Scholar