Resuscitation by hyperbaric exposure from a venous gas emboli following laparoscopic surgery
© Kjeld et al.; licensee BioMed Central Ltd. 2012
Received: 13 November 2011
Accepted: 11 July 2012
Published: 3 August 2012
Venous gas embolism is common after laparoscopic surgery but is only rarely of clinical relevance. We present a 52 year old woman undergoing laparoscopic treatment for liver cysts, who also underwent cholecystectomy. She was successfully extubated. However, after a few minutes she developed cardiac arrest due to a venous carbon dioxide (CO2) embolism as identified by transthoracic echocardiography and aspiration of approximately 7 ml of gas from a central venous catheter. She was resuscitated and subsequently treated with hyperbaric oxygen to reduce the size of remaining gas bubbles. Subsequently the patient developed one more episode of cardiac arrest but still made a full recovery. The courses of events indicate that bubbles had persisted in the circulation for a prolonged period. We speculate whether insufficient CO2 flushing of the laparoscopic tubing, causing air to enter the peritoneal cavity, could have contributed to the formation of the intravascular gas emboli. We conclude that persistent resuscitation followed by hyperbaric oxygen treatment after venous gas emboli contributed to the elimination of intravascular bubbles and the favourable outcome for the patient.
Laparoscopic surgery with carbon dioxide (CO2) insufflation affects circulatory, pulmonary, renal, splanchnic, and endocrine functions but such perturbations are, most often, of little clinical significance . Yet cardiac arrest has been reported following 2–20 of 100,000 laparoscopic procedures , and cardiac arrest seems to be related to a vasovagal response following rapid peritoneal distension and gas embolism . Human and animal studies of laparoscopic surgery indicate gas embolism in about half of the cases, as detected by transoesophageal echocardiography [4–6]. Symptomatic supportive care is the primary therapeutic modality for venous gas embolism (VGE), while hyperbaric oxygen therapy is the first line of treatment for arterial gas embolism [7, 8]. Here, we report of a patient who survived significant gas embolism by aspiration of the embolus followed by hyperbaric oxygen treatment.
A female patient (52 years, 56 kg, ASA II) underwent laparoscopic marsupialization for liver cysts and also cholecystectomy. The patient was undergoing treatment with thiazide diuretics and a renin-angiotensin inhibitor for hypertension but had no other illnesses as evaluated by routine laboratory tests. The patient was pre-medicated with oral dexamethasone 4 mg. Anaesthesia was induced with propofol 200 mg and maintained with propofol and remifentanil. After induction of anaesthesia, oral intubation was facilitated with rocuronium 40 mg, which was increased to a total dose of 90 mg guided by ‘train of four’ . The ventilation was controlled with an inspired oxygen fraction (FiO2) of 0.50, end-tidal tension of carbon dioxide (ET’CO2) was between 28 and 34 mmHg and a positive end-expiratory pressure (PEEP) of 5 cm H2O. Blood pressure was monitored noninvasively on the right arm and oxygen saturation was measured by a pulse oximeter.
The patient was referred to a nearby hospital and treated in a hyperbaric chamber at a pressure of 2.8 ATA. The patient was ventilated with 100% oxygen. Within 2 h and 37 min, the fluid balance was 1000 ml positive and the inotropic medication was discontinued when systolic pressure was 140 mmHg. The patient was sedated with fentanyl 2 ml/h and propofol 20 ml/h  and by then no longer had frothy pink sputum. When the pressure was lowered to 1.9 ATA the patient developed non-sustained ventricular fibrillation followed by bradycardia.
It was believed that the ventricular fibrillation and subsequent cardiac arrest was a result of reperfusion rather than VGE and the hyperbaric treatment was therefore terminated.
The patient was referred to the ICU where, on arrival, she again developed cardiac arrest with PEA. Treatment was with adrenaline 1 mg, atropine 3 mg, and uninterrupted manual compression while mechanical ventilation with 100% oxygen was continued. Transthoracic echocardiography showed no movement of the ventricular walls and extracorporeal membrane oxygenation was considered, while adrenaline administration was repeated every 2–4 min. The patient then went into ventricular fibrillation, but after one biphasic direct current shock of 200 J, return of cardiac function was obtained after 18 min. The patient was then monitored according to a hypothermia algorithm that included continuous ECG, a central venous catheter and an arterial catheter. Temperature was monitored using a Foley catheter. Goals of treatment were a mean arterial pressure (MAP) of 65–100 mmHg (by continuous dopamine infusion, 2–10 μg/kg/min), heart rate 40–90 min − 1, central venous pressure 2–10 mmHg, blood glucose 4.5–6.1 mmol/L, and diuresis > 1 mL/kg/h. Active cooling was initiated with ice packs and infusion of 30 mL/kg of 4°C Ringer’s solution as well as continued therapeutic surface cooling using an Allon Thermowrap TM (MTRE, Israel). The target core temperature was 32.5–35.5°C and it was maintained for 24 h with subsequent rewarming by 0.5°C per hour until normothermia. Meanwhile, the patient was sedated to a Ramsey score 6 (propofol 0.3–4.0 mg/kg/h, fentanyl 100 μg/h) and paralysis during muscle shivering (cisatracurium, 0.06–0.12 mg/kg/h) .
On post-operative day (POD) 1, arterial blood gas analysis and chest X-ray findings were normal. On POD 2, the patient was extubated and transferred to a cardiology unit and she made a full recovery on POD 4. Repeated transthoracic echocardiography showed a normal ejection fraction, no valvulopathy, pulmonary hypertension, or pericardial exudations, but a possible small ventricular septum defect. ECG showed no sign of infarction. Ultrasonography of the liver revealed no sequelae and clinical neurological assessment was normal.
The risk of iatrogenic gas embolism is low. Three cases per 100,000 may be in need of hyperbaric treatment for gas embolisms and only 7/4,727,496 cases are described as being caused by laparoscopic surgery with intraperitoneal insufflation of CO2.
However, in the case presented here, the patient went through laparoscopic liver surgery and cholecystectomy with an inherent risk of VGE, since liver veins are little prone to collapse in the supine position [12, 13]. The effect of VGE depends on the rate of CO2 infusion and its volume . For adults, the potentially lethal volume is estimated at 200–300 ml or 3–5 mL/kg . The effect VGE also depends on whether the patient is breathing spontaneously, yielding a negative thoracic pressure during inspiration and hence facilitating air entrapment, or whether the patient is under positive pressure ventilation, possibly supplemented by PEEP.
The essential pathological factor is pulmonary gas embolism. Tachyarrhythmias are common following VGE and the electrocardiogram demonstrates a right heart strain pattern as well as ST–T changes, and blood pressure decreases with cardiac output. Pulmonary symptoms following VGE include dyspnoea, continuous coughing, and chest pain. Gasping for air reduces the intrathoracic pressure and may be a sign of air entrapment. Pulmonary signs of VGE include rales, wheezing, and tachypnoea. The central nervous system may be affected by VGE by cardiovascular collapse secondary to reduced cardiac output from right ventricular failure or myocardial ischemia, which rapidly results in cerebral hypoperfusion . In the present case, the VGE did probably not pass the interventricular septum, as no gas was seen on the left side of the heart and the patient recovered without any apparent neurological deficits despite three episodes of cardiac arrest and prolonged resuscitation.
The most widely used gas for laparoscopic procedures is CO2. CO2 is inexpensive, non-flammable and has the additional advantage of being readily available. Since CO2 has a high Ostwald’s solubility coefficient in blood and tissue (L = 0.54 ml per ml whole blood ), and since blood holds a high buffering capacity for CO2, VGE’s consisting of CO2 are quickly absorbed should they occur. When insufflated into the abdominal cavity, CO2 diffuses across the peritoneum, and, more importantly, is carried by the circulation to the lungs and expired. However, as demonstrated by SP Taylor and GM Hoffman, substantial amounts of air (containing 79% of the insoluble N2) may be insufflated into the peritoneal cavity from the tubing, if the system is not adequately purged with CO2 gas before insertion [18, 19]. The VGE in the present case may therefore be a combination of a CO2 and air embolism. Whether or not air contamination of the peritoneal cavity was a matter of significance in the present case remains speculative, as we were not capable of measuring the gas content of the bubbles aspirated through the central venous catheter. Although surgeons routinely purge laparoscopic tubing systems with CO2 gas, as was the standard operational procedure in the present case, surgeons and anaesthetists should be aware of the risk of simultaneous CO2 and air embolisms during these procedures.
In the case of air bubble contamination during laparoscopic procedures, AB Branger et al.  have demonstrated that microscopic N2 bubbles (50 nl) having a cylindrical shape in the capillary vessels will dissolve in > 300 min. Larger emboli, in the size of millilitres, would require even longer resorption time if left untreated, and air bubbles have been observed to persist within the vasculature for more than 48 h . The molar flux of any permeating ideal gas species present in blood and tissues obeys Fick’s first law of diffusion [21, 22] whereby each gas will have a flux through the surface area of the gas emboli, driven by the partial pressure difference between the inside of the emboli and surrounding tissue and blood. It is conceivable that larger gas emboli of CO2 may persist in blood vessels and tissues long enough for them to equilibrate with other gases present in blood and tissues (i.e. oxygen, nitrogen and water vapour), thereby increasing the bubble resolution time considerably, as demonstrated by Barrera et al. . During anaerobic metabolism, such as with gas embolism blocking microcirculation, large amounts of CO2 would be liberated from bicarbonate stores of blood and tissue, resulting in high levels of local PCO2, thereby reducing the partial pressure gradient of CO2 from the emboli to blood, which could contribute considerably to the bubble volume or reduce the rate of CO2 disappearance from the emboli .
If large iatrogenic VGE causes hemodynamic changes, treatment in a hyperbaric chamber combined with 100% oxygen breathing is well indicated [14, 25, 26]. If available, such treatment will often consist of compression of the patient to 285 kPa (i.e. 2.8 atm abs) breathing oxygen. The purpose is to 1) reduce the intravascular bubble size by compression of the gas phase according to Boyles Law, 2) maximize gas partial pressure gradients from bubbles and tissues to blood thereby increasing the speed of bubble elimination, and 3) to introduce systemic hyperoxia in an otherwise hypoxic tissue. The first goal is almost immediately achieved by compression regardless of the breathing mixture used, whereas oxygen breathing would achieve the latter two goals. An arterial partial pressure of oxygen greater than 2000 mmHg is readily achieved. Hyperoxia also increases the distance of oxygen diffusion in tissues and offsets the embolic insult to the microvasculature. Hyperbaric oxygen is the treatment of choice for arterial gas embolism . Time is important, but delayed treatment in a hyperbaric chamber may still be indicated to ameliorate the patient’s condition and reduce long term neurological sequelae.
Apparently, the patient benefited from the hyperbaric treatment. The courses of events suggest that bubbles had persisted in the circulation for a prolonged period, and that persistent resuscitation followed by hyperbaric treatment after VGE contributed to their elimination. The second cardiac arrest might have been avoided, if the pressure in the chamber had been increased instead of reducing the pressure to 1.9 ATA.
The patient has given verbal and written consent to the publication of her case report.
The authors wish to thank Professor Niels H. Secher, medical secretary Karen O’Neill and medical translator Lisbet Guhle for comments.
- Gutt CN, Oniu T, Mehrabi A, Schemmer P, Kashfi A, Kraus T, Buchler MW: Circulatory and respiratory complications of carbon dioxide insufflation. Dig Surg. 2004, 21: 95-105. 10.1159/000077038.View ArticlePubMedGoogle Scholar
- Magrina JF: Complications of laparoscopic surgery. Clin Obstet Gynecol. 2002, 45: 469-480. 10.1097/00003081-200206000-00018.View ArticlePubMedGoogle Scholar
- Galizia G, Prizio G, Lieto E, Castellano P, Pelosio L, Imperatore V, Ferrara A, Pignatelli C: Hemodynamic and pulmonary changes during open, carbon dioxide pneumoperitoneum and abdominal wall-lifting cholecystectomy. A prospective, randomized study. Surg Endosc. 2001, 15: 477-483. 10.1007/s004640000343.View ArticlePubMedGoogle Scholar
- Fors D, Eiriksson K, Arvidsson D, Rubertsson S: Gas embolism during laparoscopic liver resection in a pig model: frequency and severity. Br J Anaesth. 2010, 105: 282-288. 10.1093/bja/aeq159.View ArticlePubMedGoogle Scholar
- Schmandra TC, Mierdl S, Hollander D, Hanisch E, Gutt C: Risk of gas embolism in hand-assisted versus total laparoscopic hepatic resection. Surg Technol Int. 2004, 12: 137-143.PubMedGoogle Scholar
- Hong JY, Kim WO, Kil HK: Detection of subclinical CO2 embolism by transesophageal echocardiography during laparoscopic radical prostatectomy. Urology. 2010, 75: 581-584. 10.1016/j.urology.2009.04.064.View ArticlePubMedGoogle Scholar
- Fukaya E, Hopf HW: HBO and gas embolism. Neurol Res. 2007, 29: 142-145. 10.1179/016164107X174165.View ArticlePubMedGoogle Scholar
- Bessereau J, Genotelle N, Chabbaut C, Huon A, Tabah A, Aboab J, Chevret S, Annane D: Long-term outcome of iatrogenic gas embolism. Intensive Care Med. 2010, 36: 1180-1187. 10.1007/s00134-010-1821-9.View ArticlePubMedGoogle Scholar
- White PF: Use of cerebral monitoring during anaesthesia: effect on recovery profile. Best Pract Res Clin Anaesthesiol. 2006, 20: 181-189. 10.1016/j.bpa.2005.08.001.View ArticlePubMedGoogle Scholar
- Weaver LK: Monoplace hyperbaric chamber use of U.S. Navy Table 6: a 20-year experience. Undersea Hyperb Med. 2006, 33: 85-88.PubMedGoogle Scholar
- Bro-Jeppesen J, Kjaergaard J, Horsted TI, Wanscher MC, Nielsen SL, Rasmussen LS, Hassager C: The impact of therapeutic hypothermia on neurological function and quality of life after cardiac arrest. Resuscitation. 2009, 80: 171-176. 10.1016/j.resuscitation.2008.09.009.View ArticlePubMedGoogle Scholar
- Rasmussen A, Skak C, Kristensen M, Ott P, Kirkegaard P, Secher NH: Preserved arterial flow secures hepatic oxygenation during haemorrhage in the pig. J Physiol. 1999, 516 (Pt 2): 539-548.PubMed CentralView ArticlePubMedGoogle Scholar
- Lautt WW, Greenway CV: Conceptual review of the hepatic vascular bed. Hepatology. 1987, 7: 952-963. 10.1002/hep.1840070527.View ArticlePubMedGoogle Scholar
- Muth CM, Shank ES: Gas embolism. N Engl J Med. 2000, 342: 476-482. 10.1056/NEJM200002173420706.View ArticlePubMedGoogle Scholar
- Toung TJ, Rossberg MI, Hutchins GM: Volume of air in a lethal venous air embolism. Anesthesiology. 2001, 94: 360-361. 10.1097/00000542-200102000-00031.View ArticlePubMedGoogle Scholar
- Branger AB, Lambertsen CJ, Eckmann DM: Cerebral gas embolism absorption during hyperbaric therapy: theory. J Appl Physiol. 2001, 90: 593-600.PubMedGoogle Scholar
- Lango T, Morland T, Brubakk AO: Diffusion coefficients and solubility coefficients for gases in biological fluids and tissues: a review. Undersea Hyperb Med. 1996, 23: 247-272.PubMedGoogle Scholar
- Taylor SP, Hoffman GM: Detection of Nitrogen in Laparoscopic Insufflation Gas by Raman Spectroscopy (Ohmeda Rascal-2) (Abstract). proceedings ofAm Soc Anesthesiol. 2010, A246Google Scholar
- Taylor SP, Hoffman GM: Insufflation Technique Affects Nitrogen Concentration in Gases during Laparoscopic Procedures. procedings of Am Soc Anesthesiol. 2010, A247Google Scholar
- Sadan O, Adler M, Ezra S, Zakut H: Air embolism due to pulmonary barotrauma in a patient undergoing cesarean section. Acta Obstet Gynecol Scand. 1991, 70: 511-513. 10.3109/00016349109007171.View ArticlePubMedGoogle Scholar
- Burkard ME, Van Liew HD: Simulation of exchanges of multiple gases in bubbles in the body. Respir Physiol. 1994, 95: 131-145. 10.1016/0034-5687(94)90111-2.View ArticlePubMedGoogle Scholar
- Van Liew HD, Hlastala MP: Influence of bubble size and blood perfusion on absorption of gas bubbles in tissues. Respir Physiolo. 1969, 7: 111-121. 10.1016/0034-5687(69)90072-3.View ArticleGoogle Scholar
- Barrera F, Durant TM, Lynch PR, Oppenheimer MJ, Stauffer HM, Stewart GH: In vivo visualization of intracardiac structures with gaseous carbon dioxide; cardiovascular-respiratory effects and associated changes in blood chemistry. Am J Physiol. 1956, 186: 325-334.PubMedGoogle Scholar
- Van Liew HD, Conkin J, Burkard ME: The oxygen window and decompression bubbles: estimates and significance. Aviat Space Environ Med. 1993, 64: 859-865.PubMedGoogle Scholar
- Mirski MA, Lele AV, Fitzsimmons L, Toung TJ: Diagnosis and treatment of vascular air embolism. Anesthesiology. 2007, 106: 164-177. 10.1097/00000542-200701000-00026.View ArticlePubMedGoogle Scholar
- Muth CM, Shank ES, Larsen B: Severe diving accidents: physiopathology, symptoms, therapy. Anaesthesist. 2000, 49: 302-316. 10.1007/s001010050832.View ArticlePubMedGoogle Scholar
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