Outcome | Parameter | Crude odds ratio (95% CI) | p Value | Adjusted odds ratio (95% CI) | p Value |
---|---|---|---|---|---|
30-day mortality | Lactate level (continuous) | 1.16 (1.11–1.21) |  < 0.001 | 1.20 (1.15–1.25) |  < 0.001 |
Lactate group (mmol/L) | |||||
 < 2.0 (reference) | 1 |  | 1 |  | |
2.0–3.9 | 1.20 (0.74–1.95) | 0.464 | 1.28 (0.77–2.13) | 0.341 | |
 ≥ 4.0 | 3.65 (2.46–5.40) |  < 0.001 | 3.87 (2.54–5.91) |  < 0.001 | |
pH group | |||||
7.35–7.45 (reference) | 1 |  | 1 |  | |
 < 7.35 | 3.36 (2.27–4.98) |  < 0.001 | 3.25 (2.15–4.92) |  < 0.001 | |
 > 7.45 | 1.03 (0.56–1.88) | 0.925 | 1.05 (0.56–1.97) | 0.880 | |
CO2 group (kPa) | |||||
4.3–6.0 (reference) | 1 |  | 1 |  | |
 < 4.3 | 2.00 (1.20–3.33) | 0.008 | 2.12 (1.23–3.66) | 0.007 | |
 > 6.0 | 2.26 (1.55–3.30) |  < 0.001 | 2.12 (1.42–3.16) |  < 0.001 | |
Intensive care | Lactate level (continuous) | 1.13 (1.09–1.17) |  < 0.001 | 1.13 (1.09–1.17) |  < 0.001 |
Lactate group | |||||
 < 2.0 (reference) | 1 |  | 1 |  | |
2.0–3.9 | 1.80 (1.14–2.86) | 0.012 | 1.80 (1.14–2.86) | 0.012 | |
 ≥ 4.0 | 3.84 (2.58–5.71) |  < 0.001 | 4.02 (2.68–6.02) |  < 0.001 | |
pH group | |||||
7.35–7.45 (reference) | 1 |  | 1 |  | |
 < 7.35 | 4.43 (2.97–6.60) |  < 0.001 | 4.68 (3.12–7.02) |  < 0.001 | |
 > 7.45 | 0.84 (0.44–1.61) | 0.598 | 0.83 (0.43–1.60) | 0.579 | |
CO2 group | |||||
4.3–6.0 (reference) | 1 |  | 1 |  | |
 < 4.3 | (0.84–2.53) | 0.178 | 1.43 (0.82–2.48) | 0.204 | |
 > 6.0 | (2.15–4.58) |  < 0.001 | 3.25 (2.22–4.77) |  < 0.001 | |
Mechanical ventilation | Lactate—continuous (mmol/L) | 1.13 (1.09–1.17) |  < 0.001 | 1.13 (1.09–1.17) |  < 0.001 |
Lactate group | |||||
 < 2.0 (reference) | 1 |  | 1 |  | |
2.0–3.9 | 1.99 (1.19–3.30) | 0.008 | 1.98 (1.19–3.30) | 0.008 | |
 ≥ 4.0 | 3.84 (2.48–5.95) |  < 0.001 | 3.99 (2.56–6.22) |  < 0.001 | |
pH group | |||||
 7.35–7.45 (reference) | 1 |  | 1 |  | |
 < 7.35 | 4.44 (2.85–6.92) |  < 0.001 | 4.70 (3.00–7.37) |  < 0.001 | |
 > 7.45 | 0.81 (0.38–1.72) | 0.579 | 0.80 (0.38–1.70) | 0.563 | |
CO2 group (kPa) | |||||
4.3–6.0 (reference) | 1 |  | 1 |  | |
 < 4.3 | 1.47 (0.78–2.77) | 0.231 | 1.45 (0.77–2.74) | 0.250 | |
 > 6.0 | 3.75 (2.45–5.75) |  < 0.001 | 3.94 (2.56–6.07) |  < 0.001 | |
Need of vasopressor | Lactate—continuous (mmol/L) | 1.13 (1.08–1.17) |  < 0.001 | 1.13 (1.08–1.17) |  < 0.001 |
Lactate group | |||||
 < 2.0 (reference) | 1 |  | 1 |  | |
2.0–3.9 | 2.94 (1.53–5.66) | 0.001 | 2.95 (1.53–5.67) | 0.001 | |
 ≥ 4.0 | 5.20 (2.92–9.27) |  < 0.001 | (2.98–9.59) |  < 0.001 | |
pH group | |||||
7.35–7.45 (reference) | 1 |  | 1 |  | |
 < 7.35 | 3.29 (1.97–5.50) |  < 0.001 | 3.35 (2.00–5.61) |  < 0.001 | |
 > 7.45 | 0.78 (0.32–1.90) | 0.590 | 0.78 (0.32–1.89) | 0.585 | |
CO2 group (kPa) | |||||
4.3–6.0 (reference) | 1 |  | 1 |  | |
 < 4.3 | 1.89 (0.95–3.78) | 0.071 | 1.89 (0.95–3.79) | 0.071 | |
 > 6.0 | 2.79 (1.68–4.61) |  < 0.001 | 2.84 (1.71–4.71) |  < 0.001 | |
Urgent operation | Lactate—continuous (mmol/L) | 1.09 (1.05–1.14) |  < 0.001 | 1.09 (1.04–1.13) |  < 0.001 |
Lactate group | |||||
 < 2.0 (reference) | 1 |  | 1 |  | |
2.0–3.9 | 2.81 (1.46–5.43) | 0.002 | 2.79 (1.45–5.40) | 0.002 | |
 ≥ 4.0 | 3.21 (1.76–5.86) |  < 0.001 | 3.03 (1.65–5.57) |  < 0.001 | |
pH group | |||||
7.35–7.45 (reference) | 1 |  | 1 |  | |
 < 7.35 | 2.47 (1.43–4.27) | 0.001 | 2.51 (1.44–4.37) | 0.001 | |
 > 7.45 | 1.14 (0.50–2.61) | 0.749 | 1.13 (0.49–2.58) | 0.773 | |
CO2 group (kPa) | |||||
4.3–6.0 (reference) | 1 |  | 1 |  | |
 < 4.3 | 1.79 (0.92–3.48) | 0.088 | 1.84 (0.94–3.61) | 0.075 | |
 > 6.0 | 1.39 (0.83–2.33) | 0.213 | 1.50 (0.89–2.54) | 0.130 |