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Table 1 Study characteristics

From: Fluid resuscitation with balanced crystalloids versus normal saline in critically ill patients: a systematic review and meta-analysis

Study Sample Size (n) Age (years) Men n (%) Severity Type of balanced saline Serum creatinine Sepsis patients n (%) Invasive mechanical ventilation patients n (%) Cumulative volume of fluids (at first 24 h) (ml) Cumulative volume of fluids during follow-up period Mortality: follow-up period in days
Finfer 2022 5037 BS: 61.7(16.4)a BS: 1578(62.7) APACHE II BS: 19.0 (14.0–26.0)b Plasma-Lyte 148 BS: 127.4(109.8)a BS: 1048(42.8) BS: 1861(75.9) BS: 1609c BS: 3900 (2000–6700)b 90
   NS: 62.1(16.5)a NS: 1511(59.9) NS: 19.0 (14.0–25.0)b   NS: 125.9(112.0)a (μmol/L) NS: 1023(41.8) NS: 1881(76.8) NS: 1522c NS: 3700(2000–6300)b  
Zampieri2021 11,052 BS: 60.9(17.0)a BS: 2909(55.6) APACHE II BS: 12 (8–17)b Plasma-Lyte 148 BS: 1.2 (0.9)a BS: 966 (18.5) BS: 2304(44.2) BS: 2078c BS: 4100(2900)a 90
   NS: 61.2(16.9)a NS: 2956(55.9) NS: 12 (8–17)b   NS: 1.2 (0.9)a (mg/dl) NS: 1015(19.2) NS: 2340(44.3) NS: 2096c NS: 4100(2900)a  
Young 2015 2278 BS: 60.1(16.8)a BS: 739 (64) APACHE II BS: 14.1(6.9)a Plasma-Lyte 148 BS: 0.98 (0.76)a BS: 41 (4) BS: 768(67) BS: 1226(653–2505)b BS: 2000(1000–3500)b In hospital
   NS: 61.0(16.3)a NS: 746 (67) NS: 14.1(6.7)a   NS: 0.99 (0.68)a (mg/dl) NS: 43 (4) NS: 731 (66) NS: 1431(784–2340)b NS: 2000(1000–3300)b  
Young2014 65 BS: 38(19)a BS: 16 (73) ISS BS: 24(18)a Plasma-Lyte A BS: 1.0 (0.3)a NR NR NR BS: 10,300(2900)a 30
   NS: 39(14)a NS: 19 (79) NS: 2 22(14)a   NS: 1.0 (0.2)a (mg/dl)     NS: 4100(6500)a  
Semler 2017 974 BS: 57 (42–68)b BS: 268 (51.5) NR Lactated ringer’s solution and Plasma-Lyte A BS: 0.83 (0.67–1.09b BS: 130 (25.0) BS: 174 (33.5) BS: 1597c BS: 1600(500–3600)b 60
   NS: 58 (46–71)b NS: 246 (54.2)    NS: 0.86 (0.69–1.12)b (mg/dl) NS: 130 (28.6) NS: 155 (34.1) NS: 1238c NS: 1400(500–3400)b  
Semler 2018 15,802 BS: 58(44–69)b BS: 4540(57.2) NR Lactated ringer’s solution and Plasma-Lyte A BS: 0.89(0.74–1.10)b BS: 1167(14.7) BS: 2723 (34.3) BS: 1642c BS: 1000(0–3210)b 60
   NS: 58(44–69)b NS: 4557(58.0)    NS: 0.89(0.74–1.10)b (mg/dl) NS: 1169(14.9) NS: 2731 (34.7) NS: 1506c NS: 1020(0–3500)b  
Verma 2016 67 BS: 62(45–70)b BS: 21(63.6) NR Plasma-Lyte 148 BS: 85 (58–134)b BS: 4 (12.1) BS: 19 (57.6) BS: 1090(620–2500)b BS: 2900(1600–5600)b In hospital
   NS: 64(46–72)b NS: 21(61.8)    NS: 90 (60–121)b (μmol/L) NS: 3 (8.9) NS: 19 (55.9) NS: 1275(435–2243)b NS: 3400(1200–5800)b  
Ratanarat 2017 181 NR NR NR NR NR NR NR NR NR NR
  1. APACHE, Acute Physiology and Chronic Health Evaluation; BS: Balanced saline; NS: Normal saline; NR, not report; ISS, Injury Severity Score; aMean ± standard error. bMedian (interquartile range). cMean