Variables | NSH | No NSH | P valuea | |
---|---|---|---|---|
All | Matched (1:3) | |||
N | 6682 | 696 | 232 | Â |
Age | 0.959 | |||
 Mean (SD) | 55.0 (21.0) | 64.5 (20.1) | 64.6 (20.3) |  |
 Median (Q1–Q3) | 57.0 (38.0–74.0) | 71.0 (51.0–80.0) | 73.0 (51.8–80.0) |  |
Sex (female)—N (%) | 1775 (26.6) | 213 (30.6) | 71 (30.6) | 1.000 |
Occupational status—N (%) | 0.013 | |||
 Worker | 1633 (28.6) | 120 (20.5) | 38 (21.2) |  |
 Retired | 1594 (28.0) | 265 (45.2) | 102 (57.0) |  |
 Unemployed | 247 (4.3) | 16 (2.7) | 6 (3.4) |  |
 Student | 275 (4.8) | 10 (1.7) | 4 (2.2) |  |
 Disabled/Sheltered employment | 104 (1.8) | 11 (1.9) | 3 (1.7) |  |
 Unknown | 1849 (32.4) | 164 (28.0) | 26 (14.5) |  |
 Missingb | 980 | 110 | 53 |  |
Marital status—N (%) | 0.055 | |||
 Unmarried/single | 1204 (21.1) | 79 (13.5) | 21 (11.7) |  |
 Married | 2033 (35.6) | 225 (38.4) | 88 (49.2) |  |
 Separated/divorced | 172 (3.0) | 16 (2.7) | 8 (4.5) |  |
 Widowed | 399 (7.0) | 69 (11.8) | 17 (9.5) |  |
 Unknown | 1896 (33.2) | 197 (33.6) | 45 (25.1) |  |
 Missingb | 978 | 110 | 53 |  |
Education level—N (%) | 0.015 | |||
 No schooling | 117 (2.1) | 13 (2.2) | 4 (2.2) |  |
 Primary school/elementary school | 1230 (21.6) | 133 (22.7) | 63 (35.2) |  |
 High school diploma | 1043 (18.3) | 81 (13.8) | 19 (10.6) |  |
 University degree or higher | 243 (4.3) | 16 (2.7) | 2 (1.1) |  |
 Unknown | 3071 (53.8) | 343 (58.5) | 91 (50.8) |  |
 Missingb | 978 | 110 | 53 |  |
Comorbidities—N (%) | ||||
 Any comorbidityc | 3506 (52.5) | 458 (65.8) | 154 (66.4) | 0.873 |
 Antiplatelet therapy | 517 (7.7) | 63 (9.1) | 20 (8.6) | 0.842 |
 Arrhythmia | 608 (9.1) | 108 (15.5) | 36 (15.5) | 1.000 |
 Cerebrovascular disease | 449 (6.7) | 74 (10.6) | 19 (8.2) | 0.283 |
 COPD | 262 (3.9) | 37 (5.3) | 14 (6.0) | 0.678 |
 Dementia | 180 (2.7) | 14 (2.0) | 7 (3.0) | 0.372 |
 Drug-induced coagulopathy | 370 (5.5) | 67 (9.6) | 20 (8.6) | 0.649 |
 Diabetes Type II | 706 (10.6) | 81 (11.6) | 26 (11.2) | 0.859 |
 Hypertension | 2083 (31.2) | 316 (45.4) | 102 (44.0) | 0.703 |
 Myocardial infarction | 358 (5.4) | 49 (7.0) | 25 (10.8) | 0.069 |
Penetrating trauma—N (%) | 210 (3.1) | 16 (2.3) | 4 (1.7) | 0.602 |
Traffic accident—N (%) | 3052 (45.7) | 257 (36.9) | 84 (36.2) | 0.844 |
Trauma dynamic—N (%) | 0.493 | |||
 High-energy impact | 2833 (42.4) | 232 (33.3) | 68 (29.3) |  |
 Low-energy impact | 2418 (36.2) | 330 (47.4) | 119 (51.3) |  |
 Other | 1430 (21.4) | 134 (19.3) | 45 (19.4) |  |
 Missing | 1 | 0 | 0 |  |
Pre-treatment GCS—N (%) | 0.382 | |||
 Mean (SD) | 8.9 (4.4) | 11.0 (4.3) | 11.2 (4.3) |  |
 Median (Q1-Q3) | 8 (5–13) | 13 (7 -15) | 13 (8–15) |  |
 3–8 | 3354 (50.2) | 195 (28.0) | 62 (26.7) |  |
 9–13 | 1735 (26.0) | 211 (30.3) | 60 (25.9) |  |
 14–15 | 1593 (23.8) | 290 (41.7) | 110 (47.4) |  |
Main lesion—N (%) | ||||
 Cerebral contusion/laceration | 1715 (25.7) | 125 (18.0) | 40 (17.2) | 0.804 |
 Extradural/epidural haematoma | 581 (8.7) | 42 (6.0) | 10 (4.3) | 0.323 |
 Traumatic subdural haematoma | 2216 (33.2) | 161 (23.1) | 59 (25.4) | 0.476 |
 Intraparenchymal bleeding | 554 (8.3) | 138 (19.8) | 47 (20.3) | 0.887 |
 Diffuse injury without oedema | 422 (6.3) | 19 (2.7) | 5 (2.2) | 0.633 |
 Diffuse injury with oedema | 301 (4.5) | 18 (2.6) | 5 (2.2) | 0.715 |
 Subarachnoid haemorrhage | 755 (11.3) | 171 (24.6) | 60 (25.9) | 0.693 |
 Skull fracture | 138 (2.1) | 22 (3.2) | 6 (2.6) | 0.658 |
Injuries other than TBId—N (%) | ||||
 Isolate TBI | 3595 (53.8) | 398 (57.2) | 123 (53.0) | 0.268 |
 Abdomen | 652 (9.8) | 35 (5.0) | 10 (4.3) | 0.659 |
 Chest | 2089 (31.3) | 193 (27.7) | 73 (31.5) | 0.276 |
 Pelvis, bones, joints and muscles | 1458 (21.8) | 154 (22.1) | 42 (18.1) | 0.194 |
 Major vessels | 176 (2.6) | 14 (2.0) | 1 (0.4) | 0.134 |
 Spine | 1363 (20.4) | 135 (19.4) | 46 (19.8) | 0.886 |
 Other | 17 (0.3) | 2 (0.3) | 0 (0.0) | 1.000 |
Time between injury and ICU adm. (hours) | 0.085 | |||
 Mean (SD) | 8.3 (10.2) | 9.1 (12.0) | 7.6 (9.3) |  |
 Median (Q1-Q3) | 4.8 (2.9–8.5) | 4.5 (2.7–9.0) | 5.0 (2.8–7.4) |  |
 Missing | 1232 | 119 | 17 |  |
Pupils at ED arrival—N (%) | 0.985 | |||
 Bilaterally reactive/miotic | 4776 (71.5) | 583 (83.8) | 195 (84.1) |  |
 Unilaterally dilated/non-reactive | 1044 (15.6) | 54 (7.8) | 19 (8.2) |  |
 Bilaterally dilated/non-reactive | 637 (9.5) | 36 (5.2) | 11 (3.0) |  |
 Not available | 225 (3.4) | 23 (3.3) | 7 (3.0) |  |
Hypotension—N (%) | 990 (14.8) | 57 (8.2) | 19 (8.2) | 1.000 |
Hypoxia—N (%) | 1587 (23.8) | 74 (10.6) | 24 (10.3) | 0.902 |
Haemorrhagic-hypovolemic shock on ICU admission—N (%) | 702 (10.5) | 31 (4.5) | 10 (4.3) | 0.927 |
Neurogenic shock on ICU admission—N (%) | 523 (7.8) | 27 (3.9) | 10 (4.3) | 0.771 |
SAPS II (worst 24Â h from ICU admission) | 0.877 | |||
 < 41 [probability: 0.00–0.25] | 2085 (46.3) | 330 (56.7) | 120 (57.4) |  |
 41–51 [probability: 0.26–0.50] | 925 (20.6) | 89 (15.3) | 31 (14.8) |  |
 52–63 [probability: 0.51–0.75] | 808 (18.0) | 97 (16.7) | 38 (18.2) |  |
 > 63 [probability: 0.76–1.00] | 682 (15.2) | 66 (11.3) | 20 (9.6) |  |
 SAPSII not assessable | 2182 | 114 | 23 |  |
Worst CT scan of first 48 h in ICU—N (%) |  | |||
Marshall scale | 0.943 | |||
 Diffuse Injury I | 730 (10.9) | 159 (22.8) | 55 (23.7) |  |
 Diffuse Injury II | 2339 (35.0) | 291 (41.8) | 91 (39.2) |  |
 Diffuse Injury III | 631 (9.4) | 42 (6.0) | 13 (5.6) |  |
 Diffuse Injury IV | 229 (3.4) | 34 (4.9) | 11 (4.7) |  |
 Mass lesion (V or VI) | 2753 (41.2) | 170 (24.4) | 62 (26.7) |  |
Midline shift > 5 mm | 2150 (32.2) | 139 (20.0) | 51 (22.0) | 0.511 |
Lesion volume > 25 ml | 2217 (33.2) | 148 (21.3) | 54 (23.3) | 0.520 |
Petechiae | 2419 (36.2) | 180 (25.9) | 59 (25.4) | 0.897 |
Cistern condition | 0.622 | |||
 Normal | 3046 (45.6) | 339 (48.7) | 105 (45.3) |  |
 Compressed or distorted | 2541 (38.0) | 182 (26.1) | 67 (28.9) |  |
 Absent | 1095 (16.4) | 175 (25.1) | 60 (25.9) |  |