Table 1 Main characteristics of the original studies included in the meta-analysis
Study | Study design | Primary outcome of the study | Head trauma dynamic | Patients enrolled in the original study (No.) | Patients enrolled in this meta-analysis (No.) | Reference standard for delayed bleeding |
|---|---|---|---|---|---|---|
ANTONI_2019 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents | Blunt head trauma | 793 | 108 | RHCT after at least 24 h |
BATTLE_2017 | Retrospective | Incidence of delayed ICH in elderly trauma patients on antithrombotic agents | Blunt head trauma | 110 | 44 | RHCT at 6 h |
CHENOWETH_2018 | Prospective | Incidence of delayed ICH after head injury | Blunt head trauma | 859 | 190 | Telephone FU and EMR review |
ERNSTBRUNNER_2016 | Retrospective | S100B prediction for delayed ICH after MTBI in patients on LDA | MTBI (GCS > 13) | 384 | 382 | RHCT within 48 h |
GALLIAZZO_2019 | Retrospective | Incidence of ICH after MTBI in patients on antithrombotic agents | MTBI (GCS ≥ 13) | 1846 | 131 | RHCT at 24 h |
GANETSKY_2017 | Prospective | Incidence of ICH after minor falls in patients on antithrombotic agents | Head trauma after ground level fall | 939 | 637 | Informatic FU and EMR review at 30 days |
HILL_2018 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents | Blunt head trauma | 338 | 213 | RHCT within 48 h |
HUANG_2019 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents | Blunt head trauma | 349 | 119 | RHCT at 4–6 h |
MANN_2018 | Retrospective | Incidence of delayed ICH after a minor fall in elderly patients on antithrombotic agents | Head trauma after minor fall | 218 | 114 | RHCT before discharge |
NISHIJIMA_2012 | Prospective | Incidence of immediate and delayed ICH after blunt head trauma in patients on warfarin or clopidogrel | MTBI (GCS ≥ 13) | 1064 | 239 | Telephone FU and EMR review at 14 days |
PECK_2011 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on prescription antithrombotic agents | Blunt head trauma | 500 | 103 | EMR and informatic FU |
SCANTLING_2017 | Retrospective | Incidence of delayed ICH after MTBI in patients on antithrombotic agents | MTBI (GCS > 13) | 234 | 165 | RHCT at 12 h |
STANITSAS_2016 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents | Blunt head trauma | 71 | 40 | RHCT |
SWAP_2016 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on warfarin or clopidogrel | Blunt head trauma | 491 | 260 | FU from medical records at 60 days |
TAUBER_2009 | Prospective | Incidence of delayed ICH after MTBI in elderly patients on LDA | MTBI (GCS 15) | 100 | 100 | RHCT at 12–24 h |
TAYLOR_2012 | Retrospective | Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents | Blunt head trauma | 159 | 85 | RHCT within 48 h |