Skip to main content

Table 3 Analysis of viscoelastic parameters in albumin-based colloid solutions enriched with fibrinogen (FGN) and prothrombin complex concentrate (PCC). Different FGN concentrations (0.5, 1, 2, 4, 8, 12 g/l) were combined with fixed PCC concentrations of 1 IU/ml. The albumin concentration was maintained stable at 5%. Negative controls on fibrinogen free solutions did not show any measurable ROTEM response (infinite CT). A minimum of three repeats for each concentration step was performed. The values in bold letters reflect the optimal FGN response for CRF composition

From: Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Increasing FGN concentrations over PCC 1 IU/ml
FGN conc. a 0,5 1 2 4 8 12
CT b,* 4032 ± 1949 620 ± 620 221 ± 90 117 ± 20 154 ± 27 198 ± 1
A10c,** n.a. 2.7 ± 0.6 3.6 ± 0.6 10.7 ± 0.6 25.7 ± 4.2 47 ± 1.4
MCFc,*** n.a. 3.7 ± 0.6 3.3 ± 0.6 12 ± 1.7 26.3 ± 3.1 49.5 ± 3.5
  1. *p < 0,0001, Pearson rho 0,84 for1/FGN, **p < 0,0001, Pearson rho 0,98, ***p < 0,0001, Pearson rho 0,98
  2. aFGN concentrations in g/l
  3. bCT in seconds. Mean values ± SD
  4. cA10 and MCF in mm. Mean values ± SD