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Table 2 Analysis of viscoelastic parameters in albumin-based colloid solutions enriched with prothrombin complex concentrate (PCC) and fibrinogen (FGN). Different PCC concentrations (0.05, 0.1, 0.25, 0.5, 1, 2, 4 IU/ml) were combined with fixed fibrinogen (FGN) concentrations of 4 g/l. The albumin concentration was maintained stable at 5%. Negative controls on PCC-free solutions did not show any measurable ROTEM response (infinite CT). A minimum of three repeats for each concentration step was performed. The value in bold letters is prolonged (>80s) but still reflects the optimal PCC response for CRF composition

From: Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Increasing PCC concentrations over FGN 4 g/l
PCC conc.a 0,05 0,1 0,25 0,5 1 2 4
CTb,* 613 ± 251 337 ± 46 216 ± 50 168 ± 22 117 ± 20 95 ± 40 115 ± 18
A10c,** 5.7 ± 1.5 6.3 ± 1.5 6.7 ± 0.6 8.3 ± 1.5 10.7 ± 0.6 14 ± 4.3 11.7 ± 2.1
MCFc,*** 6.3 ± 1.5 7.3 ± 2.1 7 ± 1 9.3 ± 2.3 12 ± 1.7 14.3 ± 4.9 12 ± 2.6
  1. *p < 0,0001, Pearson rho 0,9 for1/CT, **p = 0,0013, Pearson rho 0,65, ***p = 0,0063, Pearson rho 0,57
  2. aPCC concentrations in IU/ml refer to final factor IX concentrations as reference protein in this product
  3. bCT in seconds. Mean values ± SD
  4. cA10 and MCF in mm. Mean values ± SD