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Table 1 Baseline characteristics for each type of anticoagulation

From: Falls in ED patients: do elderly patients on direct oral anticoagulants bleed less than those on vitamin K antagonists?

 

VKA (n = 1021)

DOAC (n = 426)

Total (n = 1447)

p

Demographic characteristic

 Sex, male, [n (%)]

508 (49.8)

217 (50.9)

725 (50.1)

0.681

 Age (years), med (IQR)

80 (74–85)

80 (74–85)

80 (74–85)

0.240

Comorbidities

 HAS-BLED Score, [med (iqr)]

3 (2–3)

3 (2–3)

3 (2–3)

0.083

 Charlson Comorbidity Index, [med (iqr)]

6 (4–8)

6 (5–8)

6 (4–8)

0.015

 No. of drugs, [med (iqr)]

7 (4–10)

8 (5–10)

7 (5–10)

0.008

 No. of diagnoses, [med (iqr)]

5 (4–6)

5 (4–6)

5 (4–6)

0.004

 Hypertension, [n (%)]

744 (72.9)

325 (76.3)

1069 (73.9)

0.177

 Diabetes, [n (%)]

229 (22.4)

99 (23.2)

328 (22.7)

0.737

 CHF, [n (%)]

225 (22.0)

103 (24.2)

328 (22.7)

0.375

 Coronary artery disease, [n (%)]

97 (9.5)

43 (10.1)

140 (9.7)

0.728

 Cerebrovascular disease,[n (%)]

228 (22.3)

131 (30.8)

359 (24.8)

0.001

 Hemiplegia, [n (%)]

115 (11.3)

50 (11.7)

165 (11.4)

0.796

 Renal insufficiency, [n (%)]

401 (39.3)

145 (34.0)

546 (37.7)

0.061

 PAVD, [n (%)]

117 (11.5)

27 (6.3)

144 (10.0)

0.003

 Liver disease, [n (%)]

17 (1.7)

13 (3.1)

30 (2.1)

0.092

 COPD, [n (%)]

98 (9.6)

53 (12.4)

151 (10.4)

0.107

 Malignancy, [n (%)]

104 (10.2)

59 (13.8)

163 (11.3)

0.045

 Dementia, [n (%)]

106 (10.4)

73 (17.1)

179 (12.4)

< 0.001

 Alcoholism, [n (%)]

8 (0.8)

14 (3.3)

22 (1.5)

< 0.001

 Connective tissue disease, [n (%)]

36 (3.5)

14 (3.3)

50 (3.5)

0.820

 Peptic ulcer disease, [n (%)]

174 (17.0)

94 (22.1)

268 (18.5)

0.025

 AIDS, [n (%)]

0 (0.0)

0 (0.0)

0 (0.0)

–

 History of bleeding, [n (%)]

177 (17.3)

78 (18.3)

255 (17.6)

0.658

  1. Abbreviations: CHF Congestive heart failure, COPD Chronic obstructive pulmonary disease, CVI Cerebrovascular insult, DOAC Direct oral anticoagulant, iqr Interquartile range, med Median, TIA Transient ischemic attack, PAVD Peripheral artery disease, VKA Vitamin K antagonist