Analysis | Outcome or moderator variables | Number of included studies | Odds ratio (95% confidence interval) | I2, % | p for mixed-effects meta-regression analysis |
---|---|---|---|---|---|
Main analysis | Favorable neurological outcome at hospital discharge | 0.60 (0.27–1.33) | 95 | NA | |
Subgroup analysis | |||||
Study period | Before 2010 | 1 [19] | 0.22 (0.11–0.42) | 0 | 0.19 |
After 2010 | 0.73 (0.33–1.63) | 94 | |||
Study region | North America | 0.60 (0.20–1.79) | 94 | > 0.99 | |
Europe | 0.57 (9.94E-06-32,578.24) | 94 | |||
Selection of vascular access | First attempted vascular access | 0.49 (0.09–2.66) | 94 | 0.56 | |
Actual vascular access | 0.73 (0.07–7.22) | 95 | |||
EMS response time | Longer than 10 mins | 1 [22] | 1.30 (0.97–1.73) | 0 | 0.29 |
Shorter than 10 mins | 0.51 (0.21–1.26) | 94 | |||
Time to intervention | Timing adjusted in analysis | 0.89 (0.48–1.66) | 89 | 0.02 | |
Timing not adjusted in analysis | 0.22 (0.17–0.30) | 0 | |||
Type of effect estimates pooled in analysis | Adjusted effect estimates | 0.71 (0.30–1.65) | 95 | 0.25 | |
Unadjusted effect estimates | 1 [24] | 0.23 (0.11–0.50) | 0 | ||
Initial arrest rhythm | Shockable rhythms | 0.64 (0.27–1.53) | 90 | NA |