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Table 2 Association of therapeutic hypothermia with favorable neurological outcomes in CA patients receiving ECPR

From: Associations of therapeutic hypothermia with clinical outcomes in patients receiving ECPR after cardiac arrest: systematic review with meta-analysis

Subgroup

N

OR

LCI

UCI

POR

Model

Phetero

I2

Pbegg

Pegger

Overall

9

3.507

2.194

5.607

< 0.001

F

0.703

0.00%

0.048

0.008

Control type

 Other temperature controls

5

3.067

1.750

5.374

< 0.001

F

0.387

3.50%

  

 Non-TH induction

4

4.794

2.037

11.282

< 0.001

F

0.891

0.00%

  

Regions

1

         

 Japan

4

4.803

2.196

10.505

< 0.001

F

0.627

0.00%

  

 Korea

3

2.740

1.324

5.673

0.007

F

0.342

6.70%

  

Sample size

1

         

  < 80

4

4.814

1.873

12.378

0.001

F

0.438

0.00%

  

  ≥ 80

5

3.162

1.841

5.428

< 0.001

F

0.697

0.00%

  

CA location

 Mixed

4

2.828

1.587

5.039

< 0.001

F

0.577

0.00%

  

 OHCA

5

5.320

2.382

11.881

< 0.001

F

0.744

0.00%

  

mNOS score

1

         

  ≥ 7

5

3.456

1.968

6.070

< 0.001

F

0.374

5.70%

  

  < 7

4

3.627

1.553

8.468

0.003

F

0.741

0.00%

  

OR obtained methods

 U

6

4.428

2.211

8.870

< 0.001

F

0.699

0.00%

  

 M

3

2.885

1.527

5.449

0.001

F

0.428

0.00%

  

Follow-up

1

         

 Discharge/30 days

6

2.889

1.690

4.940

< 0.001

F

0.813

0.00%

  

 90 days

3

6.592

2.505

17.349

< 0.001

F

0.573

0.00%

  
  1. Abbreviations: TH therapeutic hypothermia; CA cardiac arrest; IHCA in of hospital cardiac arrest; OR odds ratios; 95%CI 95% confidence interval; LCI lower 95% confidence interval; UCI upper 95% confidence interval; F fixed-effects model; R random-effects model; Phetero, P-value for heterogeneity; Pbegg, P-value for Begg’s test; Pegger, P-value for Egger’s test; U univariate analysis; M multivariate analysis; mNOS modified Newcastle-Ottawa scale