Skip to main content

Table 1 Patient demographics before and after propensity matching

From: Effect of dextran-70 on outcome in severe sepsis; a propensity-score matching study

  Unmatched groups Standardized difference P-value Propensity-matched groups Standardized difference P-value
  Control N = 342 Dextran N = 436    Control N = 245 Dextran N = 245   
Pre-existing conditions
 Age, mean (SDa) 61.4 (17) 66.0 (15) 0.29 0.0001 63.6 (16) 63.7 (16) 0.009 0.92
 Male gender, no (%) 140 (41) 198 (45) 0.09 0.21 102 (42) 103 (42) 0.08 0.93
 Blood malignancyb, no (%) 58 (17.0) 20 (4.6) 0.41 0.0001 18 (7) 17 (17) 0.02 0.86
 COPDc, no (%) 39 (11) 51 (12) 0.0092 0.89 32 (13) 32 (13) 0.00 1.00
 Chronic renal failure, no (%) 14 (4.1) 10 (2.3) 0.10 0.15 10 (4.1) 9 (3.7) 0.02 0.82
 Cirrhosis, no (%) 15 (4.4) 11 (2.5) 0.10 0.15 10 (4.1) 10 (4.1) 0.00 1.00
 Diabetes, no (%) 38 (11) 45 (10) 0.03 0.72 28 (11) 31 (13) 0.04 0.68
 Immunosuppressiond, no (%) 54 (16) 38 (8.7) 0.22 0.002 26 (10.6) 22 (9.0) 0.05 0.54
 Malignancye, no (%) 46 (13) 62 (14) 0.02 0.76 32 (13) 32 (13) 0.00 1.00
 Nosocomial infectionf, no (%) 44 (13) 31 (7) 0.19 0.007 21 (8.6) 23 (9.4) 0.03 0.75
 Surgeryg, no (%) 71 (21) 92 (21) 0.008 0.91 51 (21) 51 (21) 0.00 1.00
 GIh bleeding, no (%) 3 (0.9) 3 (0.7) 0.02 0.77 1 (0.4) 2 (0.8) 0.05 0.56
 DICi, no (%) 39 (11) 35 (8) 0.11 0.11 20 (8) 20 (8) 0.00 1.00
 I.C.j volume effect, no (%) 5 (1.5) 0 (0) 0.17 0.01 0 (0) 0 (0) 0.00 1.00
 Airway infection, no (%) 94 (28) 106 (24) 0.07 0.32 66 (27) 59 (24) 0.07 0.93
Physiological and laboratory variables at admissionk, mean (SD)
 Heart rate, mean (SD) 110 (24) 110 (24) 0.04 0.60 110 (24) 112 (25) 0.08 0.35
 SBPl, (mmHg) 111 (30) 103 (28) 0.04 0.60 108 (29) 108 (29) 0.006 0.95
 Lactate (mmol/L) 4.0 (3.8) 2.9 (3.1) 0.06 0.42 3.8 (3.4) 3.8 (3.1) 0.03 0.76
 Norepinephrine (μg/min) 3.7 (5.7) 5.4 (8.9) 0.24 0.002 4.0 (5.7) 3.8 (5.5) 0.03 0.76
 Temperature (°Celcius) 37.3 (1.6) 37.4 (1.2) 0.07 0.30 37.3 (1.4) 37.3 (1.2) 0.008 0.93
 Oxygenation pointsm 2.0 (1.1) 1.9 (1.1) 0.02 0.79 2.0 (1.1) 2.0 (1.1) 0.02 0.84
 Leucocytes (× 109/L) 16.6 (39.3) 14.0 (18.7) 0.09 0.22 15.5 (23.6) 15.2 (23.6) 0.01 0.89
 Platelets (× 109/L) 151 (133) 184 (119) 0.26 0.0003 173 (138) 167 (106) 0.05 0.61
 pH 7.34 (0.14) 7.32 (0.12) 0.12 0.09 7.34 (0.13) 7.34 0.11) 0.01 0.91
 Bilirubin (μmol/L) 31.0 (49.7) 20.8 (29.9) 0.25 0.0006 23.6 (26.3) 24.6 (37.8) 0.03 0.73
 Creatinine (μmol/L) 173 (136) 174 (133) 0.006 0.94 180 (137) 180 (140) 0.003 0.97
  1. aStandard deviation
  2. bLymphoma, acute leukaemia or myeloma
  3. cChronic obstructive pulmonary disease
  4. dChronic steroid treatment correlative to ≥0.3 mg/kg prednisolone/day, radiation, or chemo therapy
  5. eCancer spread beyond the regional lymph nodes
  6. fInfection that developed after ≥48 h in hospital or secondary to surgical or medical procedure
  7. gBefore admission to intensive care
  8. hGastro-intestinal
  9. iDisseminated intravascular coagulopathy
  10. jIntra-cranial
  11. kFirst value within 90 min after admission except for “Norepinephrine” which is the mean dose until the first day’s morning
  12. lSystolic blood pressure
  13. mIn accordance with SAPS 3. 1 point: PaO2 ≥ 8 kPa and spontaneous breathing (SB). 2 points PaO2 ≤ 8 kPa and SB. 3 points PaO2/FiO2 ≥ 13.3 and mechanical ventilation (MV). 4 points PaO2/FiO2 ≤ 13.3 and MV