Table 1 Patient demographics before and after propensity matching
From: Effect of dextran-70 on outcome in severe sepsis; a propensity-score matching study
Unmatched groups | Standardized difference | P-value | Propensity-matched groups | Standardized difference | P-value | |||
|---|---|---|---|---|---|---|---|---|
Control N = 342 | Dextran N = 436 | Control N = 245 | Dextran N = 245 | |||||
Pre-existing conditions | ||||||||
Age, mean (SDa) | 61.4 (17) | 66.0 (15) | 0.29 | 0.0001 | 63.6 (16) | 63.7 (16) | 0.009 | 0.92 |
Male gender, no (%) | 140 (41) | 198 (45) | 0.09 | 0.21 | 102 (42) | 103 (42) | 0.08 | 0.93 |
Blood malignancyb, no (%) | 58 (17.0) | 20 (4.6) | 0.41 | 0.0001 | 18 (7) | 17 (17) | 0.02 | 0.86 |
COPDc, no (%) | 39 (11) | 51 (12) | 0.0092 | 0.89 | 32 (13) | 32 (13) | 0.00 | 1.00 |
Chronic renal failure, no (%) | 14 (4.1) | 10 (2.3) | 0.10 | 0.15 | 10 (4.1) | 9 (3.7) | 0.02 | 0.82 |
Cirrhosis, no (%) | 15 (4.4) | 11 (2.5) | 0.10 | 0.15 | 10 (4.1) | 10 (4.1) | 0.00 | 1.00 |
Diabetes, no (%) | 38 (11) | 45 (10) | 0.03 | 0.72 | 28 (11) | 31 (13) | 0.04 | 0.68 |
Immunosuppressiond, no (%) | 54 (16) | 38 (8.7) | 0.22 | 0.002 | 26 (10.6) | 22 (9.0) | 0.05 | 0.54 |
Malignancye, no (%) | 46 (13) | 62 (14) | 0.02 | 0.76 | 32 (13) | 32 (13) | 0.00 | 1.00 |
Nosocomial infectionf, no (%) | 44 (13) | 31 (7) | 0.19 | 0.007 | 21 (8.6) | 23 (9.4) | 0.03 | 0.75 |
Surgeryg, no (%) | 71 (21) | 92 (21) | 0.008 | 0.91 | 51 (21) | 51 (21) | 0.00 | 1.00 |
GIh bleeding, no (%) | 3 (0.9) | 3 (0.7) | 0.02 | 0.77 | 1 (0.4) | 2 (0.8) | 0.05 | 0.56 |
DICi, no (%) | 39 (11) | 35 (8) | 0.11 | 0.11 | 20 (8) | 20 (8) | 0.00 | 1.00 |
I.C.j volume effect, no (%) | 5 (1.5) | 0 (0) | 0.17 | 0.01 | 0 (0) | 0 (0) | 0.00 | 1.00 |
Airway infection, no (%) | 94 (28) | 106 (24) | 0.07 | 0.32 | 66 (27) | 59 (24) | 0.07 | 0.93 |
Physiological and laboratory variables at admissionk, mean (SD) | ||||||||
Heart rate, mean (SD) | 110 (24) | 110 (24) | 0.04 | 0.60 | 110 (24) | 112 (25) | 0.08 | 0.35 |
SBPl, (mmHg) | 111 (30) | 103 (28) | 0.04 | 0.60 | 108 (29) | 108 (29) | 0.006 | 0.95 |
Lactate (mmol/L) | 4.0 (3.8) | 2.9 (3.1) | 0.06 | 0.42 | 3.8 (3.4) | 3.8 (3.1) | 0.03 | 0.76 |
Norepinephrine (μg/min) | 3.7 (5.7) | 5.4 (8.9) | 0.24 | 0.002 | 4.0 (5.7) | 3.8 (5.5) | 0.03 | 0.76 |
Temperature (°Celcius) | 37.3 (1.6) | 37.4 (1.2) | 0.07 | 0.30 | 37.3 (1.4) | 37.3 (1.2) | 0.008 | 0.93 |
Oxygenation pointsm | 2.0 (1.1) | 1.9 (1.1) | 0.02 | 0.79 | 2.0 (1.1) | 2.0 (1.1) | 0.02 | 0.84 |
Leucocytes (× 109/L) | 16.6 (39.3) | 14.0 (18.7) | 0.09 | 0.22 | 15.5 (23.6) | 15.2 (23.6) | 0.01 | 0.89 |
Platelets (× 109/L) | 151 (133) | 184 (119) | 0.26 | 0.0003 | 173 (138) | 167 (106) | 0.05 | 0.61 |
pH | 7.34 (0.14) | 7.32 (0.12) | 0.12 | 0.09 | 7.34 (0.13) | 7.34 0.11) | 0.01 | 0.91 |
Bilirubin (μmol/L) | 31.0 (49.7) | 20.8 (29.9) | 0.25 | 0.0006 | 23.6 (26.3) | 24.6 (37.8) | 0.03 | 0.73 |
Creatinine (μmol/L) | 173 (136) | 174 (133) | 0.006 | 0.94 | 180 (137) | 180 (140) | 0.003 | 0.97 |