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Table 3 Sensitivity, Specificity, and Positive (PPV) and Negative Predictive Values (NPV) for severe sepsis by different identification tools in the Emergency department (n = 108 cases of severe sepsis among 1535 patients)

From: Poor performance of quick-SOFA (qSOFA) score in predicting severe sepsis and mortality – a prospective study of patients admitted with infection to the emergency department

Identification tool Ability to identify severe sepsis Sensitivity Specificity PPV NPV
n (% of 108 cases) (95% CI) (95% CI) (95% CI) (95% CI)
SIRS ≥2 (without leukocytes) 80 (74.1%) 0.74 (0.65-0.82) 0.72 (0.70-0.75) 0.18 (0.16-0.19) 0.97 (0.96-0.98)
qSOFA ≥2a 33 (30.6%) 0.32 (0.23-0.42) 0.98 (0.97-0.99) 0.57 (0.45-0.68) 0.95 (0.94-0.96)
Red triage 37 (34.3%) 0.34 (0.25-0.44) 0.95 (0.94-0.96) 0.35 (0.27-0.43) 0.95 (0.94-0.95)
Orange triage 55 (50.9%) 0.51 (0.41-0.61) 0.60 (0.58-0.63) 0.09 (0.07-0.11) 0.94 (0.93-0.95)
≥ Orange triage 92 (85.2%) 0.85 (0.77-0.91) 0.55 (0.52-0.58) 0.13 (0.12-0.14) 0.98 (0.97-0.99)
  1. aThe ability to identify sepsis in % is calculated based on 108 cases of sepsis in the total population, whilst the sensitivity analysis is based on the 103 cases with complete score on qSOFA