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Table 2 Characters of TBI patients with/without early post-traumatic seizure

From: Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury

 

With seizure (n = 83)

Without seizure (n = 312)

p-value

Head AIS (n, %)

 2

18, 21.69

69, 22.11

0.93

 3

25, 30.12

106, 33.97

0.51

 4

26, 31.23

90, 28.85

0.66

 5

14, 16.87

47, 15.06

0.69

GCS (n, %)

 7-8

41, 49.40

149, 47.76

0.79

 5-6

33, 39.76

123, 39.42

0.96

 3-4

9, 10.84

40, 12.82

0.63

VPA concentrations (ug/ml): mean ± sd, median

 Day1

59.12 ± 24.18, 59.0

63.96 ± 16.60, 62.5

0.03

 Day2

61.53 ± 18.23, 62.0

65.92 ± 15.37, 62.0

0.03

 Day3

63.63 ± 19.03, 63.0

69.05 ± 26.30, 71.5

0.08

 Day4

65.56 ± 16.26, 66.0

68.24 ± 24.18, 70.0

0.35

 Day5

68.14 ± 24.18, 69.0

70.05 + 23.26, 68.0

0.53

 Day6

73.22 ± 29.13, 70.0

75.02 ± 27.04, 73.5

0.61

 Day7

69.92 ± 26.04, 72.0

71.35 + 21.57, 72.5

0.62

Weight (kg): mean ± sd, median

73.27 ± 12.71, 72.0

72.12 ± 10.95, 70.5

0.41

ICULOS (days): mean ± sd, median

19.25 ± 6.52, 18.0

15.31 ± 7.10, 16.0

<0.01

HLOS (days): mean ± sd, median

20.32 ± 7.35, 21.0

19.01 ± 7.78, 19.0

0.17

Mortality at discharge (n, %)

11,13.25

43, 13.78

0.90

Mortality at 3 months after injury (n, %)

13, 15.66

47, 15.06

0.97

GOS at 3 months after injury

 1-3 (n, %)

72, 86.74

256, 82.05

0.31

 4-5 (n, %)

11, 13.25

56, 17.94

0.31

  1. Differences were considered statistically significant when p<0.05.
  2. sd standard deviation