Skip to main content

Table 6 Literature review of results of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest, and our results

From: Out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal membrane oxygenation: focus on survival rate and neurologic outcome

  No. of patients Survival Rate, n (%) Neurological Outcome, n (%) Remark
Kagawa et al. 2010 [1] 39 30 day
5 (13)
CPC 1–2
4 (10)
Time interval from collapse to ECLS start, min (IQR); 59(45–65).
Successful percutaneous cannulation (38/39; 97 %).
Complications after ECLS; cannula site bleeding (23/39; 59 %), acute kidney injury (9/39; 23 %), leg malperfusion (8/39; 21 %), pneumonia (7/39; 18 %), sepsis (3/39; 8 %).
Le Guen et al. 2011 [2] 42 28 day
2 (4)
CPC 1–2
2 (4)
24 h survival rate after ECLS (17/42; 40 %).
48 h survival rate after ECLS (5/42; 12 %).
28 day survival rate after ECLS (2/42; 4 %).
Avalli et al. 2012 [3] 18 28 day
1(5)
GOS ≥ 4
1 (5)
Survival rate of patients with OHCA (1/18; 5 %) lower than IHCA (11/24; 46 %).
Low flow time of OHCA (77 min) longer than IHCA (55 min).
Cannulation failure: two in OHCA (2/18; 11 %)
In OHCA, complications ECMO; distal leg perfusion (4/18; Haneya22%), femoral leg lesion (2/18; 11 %).
Haneya et al. 2012 [29] 26 Survival discharge
6 (23.1)
  Forty patients (47 %) were successfully weaned and 29 patients (34 %) survived to hospital discharge.
Maekawa et al. 2013 [5] 53 3 mon
15 (28.3)
CPC 1 or 2 at 3mon: 8 (15.1) Survival rate at 3 months (15/53; 28.3 %)
Complications after ECLS; cannulation site bleeding (17/52; 32.7 %), cannulation site infection (4/52; 7.7 %).
Pupil diameter on hospital arrival may be associated with the neurologic outcome.
Leick et al. 2013 [4] 28 11 (39.3) No check Door to ECLS implantation time < 30 min
→ significantly improved the 30 day survival
Complications after ECLS; bleeding (9/28; 32 %), lower limb ischemia (1/28; 3.6 %).
Sakamoto et al. 2014 [30] 260   32 (12.3) ECPR 26 hospitals vs. non-ECPR 20 hospitals
CPC 1–2 at 1 months: 12.3 vs. 1.5 %
CPC 1–2 at 6 moths: 11.2 vs. 2.6 %
Stub et al. 2014 [31] 9 Survival discharge
3 (33.3)
CPC 1 or 2 at discharge
3 (33.3)
CHEER trial (11 with OHCA, 15 with IHCA)
CPC score 1: 14/26 (54 %)
collapse to initiation of ECMO: 56 min
Our results 23 30 day
10 (43.5)
CPC 1: 7 (30)
CPC 4: 3 (13)
Door to ECMO team activation time < 10 min for refractory OHCA.
Rapid and accurate ECMO implantation in the catheter laboratory.
Complications after ECLS; cannulation site bleeding (3/23; 13 %).
Oliguria may be a predictor for mortality.
Brain CT just after ECMO and following brain imaging may be a predictor for neurologic outcome.
  1. n number of patients, CPC cerebral performance category, ECLS extracorporeal life support, GOS glasgow outcome scale, OHCA out-of-hospital cardiac arrest, IHCA in-hospital cardiac arrest, ECMO extracorporeal membrane oxygenation, CT computed tomography