Table 4 Genotypic and allelic frequency distribution in patients with sepsis and non-sepsis
Cytokine gene polymorphism | Genotype | Non-sepsis | Sepsis | p value | OR (95 % CI) |
|---|---|---|---|---|---|
f (%) | f(%) | ||||
n = 89 | n = 25 | ||||
IL-1α(−889) | CC | 45(50.56) | 21(84) | 1 | |
TC | 32(35.96) | 3(12) | 0.01 | 0.20(0.05–0.73) | |
TT | 12(13.48) | 1(4) | 0.17(0.02–1.4) | ||
C | 122(68.5) | 45(90) | 1 | ||
T | 56(31.5) | 5(10) | 0.002 | 0.24(0.07-0.6) | |
TNF-α(−308) | AA | 3(3.3) | 2(8) | 1 | |
GA | 17(19.1) | 1(4) | 0.09 | 0.08(0.05–1.3) | |
GG | 69(77.6) | 22(88) | 0.47(0.07–3.0) | ||
A | 23(13) | 5(10) | 1 | ||
G | 155(87) | 45(90) | 0.57 | 1.3(0.46–4.7) | |
TNF-α(−238) | GG | 78(87.7) | 19(76) | 1 | |
GA | 10(11.2) | 4(16) | 0.13 | 0.2 (0.13–2.8) | |
AA | 1(1.1) | 2(8) | 0.12(0.01–1.4) | ||
G | 166(93.2) | 42(84) | 0.04 | 1 | |
A | 12(6.8) | 8(16) | 2.6(0.87–7.5) | ||
IL-4(−1098) | TT | 66(74.1) | 12(48) | 1 | |
TG | 21(23.6) | 9(36) | 0.006 | 2.3(0.87–6.3) | |
GG | 2(2.3) | 4(16) | 11(1.8–66.9) | ||
T | 153(86) | 33(82) | 0.001 | 1 | |
G | 25(14) | 17(18) | 3.1(1.4–6.8) | ||
IL-10(−1082) | GG | 5(5.7) | 4(16) | 1 | |
GA | 33(37) | 2(8) | 0.01 | 0.07 (0.01–0.52) | |
AA | 51(57.3) | 19(76) | 0.46 (0.11–1.9) | ||
G | 30(16.9) | 10(20) | 0.60 | 1 | |
A | 148(83.1) | 40(80) | 0.8(0.34–2.0) | ||
IL-10(−819) | CC | 63(70.7) | 16(64) | 1 | |
CT | 22(24.7) | 6(24) | 0.39 | 0.10 (0.03–3.0) | |
TT | 4(4.6) | 3(12) | 0.65 (0.14–2.9) | ||
C | 148(83.1) | 12(76) | 0.001 | 1 | |
T | 30(16.9) | 31(24) | 12.7(5.5–30.1) |