Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients

Table 10 Showing the serum levels of IL-1α, TNF-α and IL-10 in healthy controls and patients

Genotype		Healthy controls		Non-sepsis		Sepsis		p Value
		Percent	pg/ml	Percent	pg/ml	Percent	pg/ml	p Value
IL-1α(−889)	CC	48.5	5.4 ± 2.8	50.5	7.2 ± 2.6	84	18.6 ± 7.8	NS, p^b<0.05, p^c<0.05
	CT	38.6	5.7 ± 1.9	35.9	8.3 ± 3.1	12	21.5 ± 8.7	NS, p^b<0.05, p^c<0.05
	TT	12.9	3.7 ± 2.7	13.6	6.7 ± 2.7	4	16.2 ± 9.2	p^a<0.05, p^b<0.05, p^c<0.05
TNF-α(−308)	AA	2.8	25.7 ± 18.6	3.3	37.5 ± 16.8	8	57.6 ± 18.7	p^a<0.05, p^b<0.001, p^c<0.001
	GA	17.2	15.4 ± 9.7	19.1	34.6 ± 13.5	4	54.7 ± 19.6	p^a<0.001, p^b<0.001, p^c<0.001
	GG	80	11.2 ± 7.2	77.6	32.5 ± 12.7	88	51.2 ± 16.3	p^a<0.05, p^b<0.001, p^c<0.0001
TNF-α(−238)	GG	90	27.6 ± 16.7	87.7	35.2 ± 14.6	76	40.6 ± 23.5	p^a<0.05, p^b<0.001, p^c<0.0001
	GA	8.5	18.5 ± 12.3	11.2	30.5 ± 13.4	16	62.8 ± 18.6	p^a<0.05, p^b<0.001, p^c<0.0001
	AA	1.5	14.8 ± 7.8	1.1	32.4 ± 12.7	8	38.8 ± 14.8	p^a<0.05, p^b<0.001, p^c<0.0001
IL-10(−1082)	GG	7.1	11.6 ± 4.7	5.7	21.6 ± 13.5	16	84.5 ± 37.5	p^a<0.01, p^b<0.0001, p^c<0.0001
	GA	18.6	14.7 ± 5.2	37	22.5 ± 15.6	8	74.6 ± 26.3	p^a<0.01, p^b<0.001, p^c<0.0001
	AA	74.3	9.2 ± 4.5	57.3	16.7 ± 11.2	76	67.8 ± 21.4	p^a<0.01, p^b<0.001, p^c<0.0001

p value (p < 0.05) considered as significant. It is calculated by two tailed Mann–Whitney, p^a(healthy controls vs. non-sepsis),p^b(healthy controls vs sepsis) and p^c(sepsis vs. non-sepsis)

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