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Table 10 Showing the serum levels of IL-1α, TNF-α and IL-10 in healthy controls and patients

From: Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients

Genotype   Healthy controls Non-sepsis Sepsis p Value
   Percent pg/ml Percent pg/ml Percent pg/ml
IL-1α(−889) CC 48.5 5.4 ± 2.8 50.5 7.2 ± 2.6 84 18.6 ± 7.8 NS, pb<0.05, pc<0.05
CT 38.6 5.7 ± 1.9 35.9 8.3 ± 3.1 12 21.5 ± 8.7 NS, pb<0.05, pc<0.05
TT 12.9 3.7 ± 2.7 13.6 6.7 ± 2.7 4 16.2 ± 9.2 pa<0.05, pb<0.05, pc<0.05
TNF-α(−308) AA 2.8 25.7 ± 18.6 3.3 37.5 ± 16.8 8 57.6 ± 18.7 pa<0.05, pb<0.001, pc<0.001
GA 17.2 15.4 ± 9.7 19.1 34.6 ± 13.5 4 54.7 ± 19.6 pa<0.001, pb<0.001, pc<0.001
GG 80 11.2 ± 7.2 77.6 32.5 ± 12.7 88 51.2 ± 16.3 pa<0.05, pb<0.001, pc<0.0001
TNF-α(−238) GG 90 27.6 ± 16.7 87.7 35.2 ± 14.6 76 40.6 ± 23.5 pa<0.05, pb<0.001, pc<0.0001
GA 8.5 18.5 ± 12.3 11.2 30.5 ± 13.4 16 62.8 ± 18.6 pa<0.05, pb<0.001, pc<0.0001
AA 1.5 14.8 ± 7.8 1.1 32.4 ± 12.7 8 38.8 ± 14.8 pa<0.05, pb<0.001, pc<0.0001
IL-10(−1082) GG 7.1 11.6 ± 4.7 5.7 21.6 ± 13.5 16 84.5 ± 37.5 pa<0.01, pb<0.0001, pc<0.0001
GA 18.6 14.7 ± 5.2 37 22.5 ± 15.6 8 74.6 ± 26.3 pa<0.01, pb<0.001, pc<0.0001
AA 74.3 9.2 ± 4.5 57.3 16.7 ± 11.2 76 67.8 ± 21.4 pa<0.01, pb<0.001, pc<0.0001
  1. p value (p < 0.05) considered as significant. It is calculated by two tailed Mann–Whitney, pa(healthy controls vs. non-sepsis),pb(healthy controls vs sepsis) and pc(sepsis vs. non-sepsis)