| Study period | ||
---|---|---|---|
 | Enrolment* | Measurement ** | Close-out |
TIMEPOINT | <T 0 | T 0 to T 72 | ICU discharge |
ENROLMENT: | Â | Â | Â |
  Eligibility screen | X |  |  |
  Informed Consent | X |  |  |
ASSESSMENTS: | Â | Â | Â |
  Baseline variables | X |  |  |
  Disease-related variables | X |  |  |
  IAP measurement |  | X |  |
  Blood sample |  | X |  |
  Urine sample |  | X |  |
  I-FABP measurement |  | X |  |
  Claudin-3 measurement |  | X |  |
  Creatinine measurement |  | X |  |
  Treatment-related variables |  | X |  |
  SOFA score |  | X |  |
  Adverse events |  | X | X |
  Length of ICU stay |  | X | X |
  Mortality during ICU stay |  | X | X |
  Secondary interventions |  | X | X |