From: Functional capacity of reconstituted blood in 1:1:1 versus 3:1:1 ratios: A thrombelastometry study
Parameter | Day 1 | Day 4 | Day 14 | Day 24 | |||||
---|---|---|---|---|---|---|---|---|---|
WB | 1:1:1 | 3:1:1 | 1:1:1 | 3:1:1 | 1:1:1 | 3:1:1 | 1:1:1 | 3:1:1 | |
Erythrocytes [×106/μl] | 3.79 ± 0.29 | 2.14 ± 0.54+ | 3.65 ± 0.85 | 2.01 ± 0.14* | 3.68 ± 0.29 | 1.96 ± 0.13* | 3.3 ± 0.34 | 2.09 ± 0.64* | 3.08 ± 0.61 |
Leukocytes [×103/μl] | 6.55 ± 2.05 | 0.25 ± 0.05+ | 0.33 ± 0.1+ | 0.37 ± 0.08 | 0.33 ± 0.14 | 0.35 ± 0.1 | 0.25 ± 0.08 | 0.45 ± 0.1 | 0.5 ± 0.18 |
Platelets [×103/μl] | 236.5 ± 43.1 | 348.5 ± 36.39+,* | 226.5 ± 28.51 | 327.5 ± 22.42* | 181 ± 44.09 | 359.17 ± 20.68* | 231.5 ± 38.83 | 334.83 ± 37.5* | 231.5 ± 58.11 |
Hemoglobin [g/dl] | 11.78 ± 1.11 | 6.6 ± 1.67+,* | 11.43 ± 2.54 | 6.2 ± 0.56* | 11.42 ± 1.08 | 6.12 ± 0.5* | 10.38 ± 1.25 | 6.47 ± 2.27* | 9.76 ± 1.71 |
Hematocrit [%] | 37.08 ± 3.21 | 20.85 ± 4.29+,* | 35.7 ± 7.14 | 20.27 ± 1.55* | 37.13 ± 3.19 | 19.5 ± 1.76* | 32.97 ± 3.88 | 21.33 ± 7.26 | 30.92 ± 5.29 |
MCHC [g/dl] | 31.75 ± 0.7 | 31.47 ± 1.27 | 31.9 ± 0.65 | 30.57 ± 0.6 | 30.72 ± 0.5 | 30.75 ± 0.18* | 31.5 ± 0.64 | 30.25 ± 0.49 | 30.83 ± 0.7 |
pH | 6.92 ± 0.06 | 7.04 ± 0.04+ | 6.95 ± 0.05 | 7.03 ± 0.05* | 6.9 ± 0.04 | 6.91 ± 0.08* | 6.76 ± 0.03 | 6.89 ± 0.03* | 6.69 ± 0.06 |
Sodium [mM] | 139.67 ± 2.33 | 142.62 ± 6.15 | 145.37 ± 5.14 | 140.48 ± 1.63* | 142.3 ± 0.89 | 138.67 ± 0.81 | 138.43 ± 2.09 | 137.42 ± 0.99 | 136.72 ± 1.67 |
Potassium [mM] | 3.33 ± 0.4 | 3.12 ± 0.38 | 2.83 ± 0.78 | 3.91 ± 0.38* | 4.69 ± 0.35 | 6.72 ± 1.3* | 9.19 ± 0.95 | 7.45 ± 0.48* | 13.01 ± 0.15 |
EXTEM CFT [s] | 101.83 ± 49.17 | 59.83 ± 10.94* | 125.33 ± 27.5 | 54.83 ± 5.49* | 127.67 ± 50.71 | 59.33 ± 16.46* | 139.5 ± 46.87 | 74.33 ± 27.98 | 99.5 ± 34.81 |
INTEM CFT [s] | 133.5 ± 67.16 | 70.33 ± 24.83 | 144.17 ± 99.03 | 55.5 ± 6.8* | 119.5 ± 39.51 | 114.17 ± 94.2 | 166.5 ± 78.58 | 67 ± 34.48 | 92.5 ± 18.17 |
APTEM CFT [s] | 119.17 ± 74.34 | 72.67 ± 22.81 | 108 ± 33.89 | 70.5 ± 16.88* | 131.33 ± 57.6 | 66.83 ± 19.06* | 133.5 ± 44.28 | 65.33 ± 30.74 | 84.33 ± 19.31 |
INR | 1.12 ± 0.1 | 1.03 ± 0.05* | 1.23 ± 0.08 | 1.13 ± 0.05* | 1.52 ± 0.25 | 1.12 ± 0.04* | 1.53 ± 0.15 | 1.17 ± 0.08* | 1.45 ± 0.14 |
PTT [s] | 38.33 ± 4.59 | 33.67 ± 3.83 | 36.83 ± 5.49 | 33.83 ± 2.79* | 44.83 ± 6.88 | 38.5 ± 4.14* | 47.67 ± 7.15 | 36.83 ± 4.4* | 43.5 ± 5.32 |
Fibrinogen [mg/dl] | 254.17 ± 51.33 | 226.83 ± 23.79 | 173.8 ± 31.3+ | 224.33 ± 21.94* | 147.33 ± 30.74 | 215.17 ± 25.56* | 143.67 ± 16.46 | 240.17 ± 20.47* | 170 ± 17.12 |
Antithrombin [%] | 77.17 ± 7.41 | 68.83 ± 7.78 | 49.17 ± 8.54+ | 64.67 ± 3.98* | 38.17 ± 7.25 | 67.17 ± 3.31* | 38.33 ± 6.12 | 63.17 ± 3.43* | 41.33 ± 3.27 |
Factor II [%] | 82.33 ± 8.33 | 76.33 ± 4.23 | 55.17 ± 7.19+ | 74 ± 5.48* | 46.33 ± 8.71 | 68.5 ± 8.07* | 43.83 ± 9.7 | 63.17 ± 5.34 | 45.67 ± 5.54 |
Factor V [%] | 81.17 ± 7.41 | 72.67 ± 6.89 | 53 ± 10.1+ | 57.33 ± 4.41* | 34.5 ± 6.25 | 58.67 ± 3.72* | 35.83 ± 2.64 | 56.33 ± 6.98* | 40.33 ± 5.09 |
Factor VII [%] | 73.67 ± 11.33 | 79.83 ± 10.46* | 56.33 ± 7.76 | 67.17 ± 9.15* | 42 ± 9.27 | 64.67 ± 9.67* | 41.33 ± 8.31 | 61.17 ± 11.41* | 45 ± 9.92 |
Factor VIII [%] | 95.33 ± 29.12 | 83.75 ± 13.35 | 57.83 ± 10.8+ | 71.8 ± 9.88* | 46.17 ± 16.55 | 53.83 ± 11.2* | 39.17 ± 8.8 | 71.67 ± 30.94 | 53.33 ± 23.89 |
Factor IX [%] | 89 ± 8.2 | 95 ± 5.22* | 70.67 ± 8.62 | 87 ± 5.33* | 54.5 ± 10.56 | 74.5 ± 10.91* | 51.17 ± 11.36 | 77.33 ± 16.37* | 50.67 ± 9.14 |
Factor X [%] | 73.5 ± 9.09 | 79.33 ± 5.92* | 54.17 ± 5.88 | 72.33 ± 8.24* | 48.83 ± 6.68 | 68.67 ± 13.98* | 44.17 ± 11.07 | 71.17 ± 10.82* | 49.83 ± 10.38 |
Factor XI [%] | 83.8 ± 29.8 | 96 ± 15.3* | 71.67 ± 6.35 | 91.83 ± 18.8 | 72.83 ± 33.88 | 72.67 ± 15.07* | 49.5 ± 12.32 | 66.5 ± 11.78* | 48.17 ± 8.33 |
Factor XII activity [%] | 86.17 ± 28.27 | 75.67 ± 9.14* | 54.67 ± 8.26+ | 88 ± 10.1* | 48.33 ± 13.85 | 76.5 ± 22.73* | 50.17 ± 20.44 | 69.67 ± 16.01* | 48.33 ± 9.42 |
Factor XIII [%] | 115.67 ± 11.18 | 100.67 ± 12.4 | 77.17 ± 10.67+ | 97.5 ± 11.71* | 67.17 ± 16.04 | 86.33 ± 6.38* | 65.5 ± 4.09 | 92.17 ± 19.05* | 61 ± 1.79 |
Protein C activity [%] | 71.67 ± 13.98 | 70.33 ± 5.96* | 50.5 ± 4.97+ | 70.67 ± 7.42* | 41.33 ± 8.36 | 60.67 ± 6.74* | 37.33 ± 7.26 | 63.67 ± 5.16* | 48.17 ± 6.97 |
Protein S activity [%] | 89.17 ± 16.93 | 60.33 ± 7.12 | 43.17 ± 11.41+ | 33 ± 4.34* | 21.17 ± 8.82 | 55 ± 8.12* | 33.33 ± 7.39 | 43.8 ± 15.42 | 28.83 ± 12.24 |
v. Willebr. activation [%] | 128.83 ± 39.78 | 97 ± 19.01 | 72.2 ± 15.9+ | 98.67 ± 18.35* | 67.17 ± 23.04 | 67.5 ± 26.61 | 46 ± 14.56 | 82.33 ± 28.11 | 60.17 ± 22.11 |
v. Willebr. antigen [%] | 141.83 ± 45.28 | 112.67 ± 27.81 | 77.2 ± 17.08+ | 114.83 ± 27.69* | 71.67 ± 22.17 | 78 ± 25.87 | 53.17 ± 17.68 | 107.83 ± 39.91 | 76.5 ± 28.74 |