Table 2 Characteristics of the datasets used to create the prognostic models and the INRO-PH validation dataset

N

778

8,509

10,008

126

574

700

Age (median, IQR)

Years

50 (28-69)

30 (21-45)

-

-

-

Age (mean, SD)

Years

49 (23)

-

37 (17)

48 (22)

43 (20)

GCS at ED (median, IQR)

Points

3 (3-8)

-

-

11

3

GCS at randomization (N, %)

Mild (13-14)

-

-

30%

-

-

Moderate (9-12)

-

-

30%

-

-

Severe (3-8)

-

-

40%

-

-

Motor GCS on admission (N, %)

None (1)

244 (31%)

1,395 (16%)

-

-

-

Extension (2)

31 (4%)

1,042 (12%)

-

-

-

Abnormal flexion (3)

72 (9%)

1,085 (13%)

-

-

-

Normal flexion (4)

133 (17%)

1,940 (23%)

-

-

-

Localizes/obeys (5/6)

218 (28%)

2,591 (30%)

-

-

-

Untestable/missing

80 (10%)

456 (5%)

-

-

-

Pupillary reactivity (N, %)

Both pupils reactive

371 (71%)

4,486 (63%)

83%

117 (93%)

374 (65%)

491 (70%)

One pupil reactive

31 (6%)

886 (12%)

7%

6 (5%)

74 (13%)

80 (11%)

No pupil reactive

123 (23%)

1,754 (25%)

8%

3 (2%)

126 (22%)

129 (18%)

Unable to assess

8 (1%)

-

3%

-

-

Major extracranial injury (N, %)

Present

389 (50%)

-

23%

-

-

Hypoxia (N, %)

Yes or suspected

117 (15%)

1,116 (20%)

-

12 (10%)

165 (29%)

177 (25%)

Hypotension (N, %)

Yes or suspected

103 (13%)

1,171 (18%)

-

7 (6%)

133 (23%)

140 (20%)

CT classification (N, %)

Diffuse Injury (I)

84 (11%)

360 (7%)

-

48 (40%)

104 (19%)

152 (22%)

Diffuse Injury (II)

327 (44%)

1,838 (35%)

-

38 (31%)

156 (29%)

194 (28%)

Diffuse Injury (III)

55 (7%)

863 (17%)

-

5 (4%)

88 (16%)

93 (13%)

Diffuse Injury (IV)

3 (1%)

187 (4%)

-

0

17 (3%)

17 (2%)

Mass lesion evacuated (V) or non-evacuated (VI)

270 (37%)

1,944 (38%)

-

30 (25%)

172 (32%)

202 (29%)

tSAH

Yes

437 (56%)

3,313 (45%)

32%

-

-

EDH

Yes

128 (16%)

999 (13%)

-

-

-

Six month outcome (N, %)

Dead

212 (27%)

2,396 (28%)

2,146 (32%)^a

29 (23%)

222 (39%)

251 (36%)

Unfavourable

265 (36%)

4,082 (48%)

3,139 (47%)^a

39 (31%)

289 (50%)

328 (47%)