Serum was available for analysis of suPAR in 5,992 patients (94% of the admitted patients). Mean age was 59.8 years and 50.1% were female. The mean concentration of suPAR was 5.5 ng/ml (± 3.6) and there was a significant correlation between suPAR level, CRP level (R2 = 0.09), and leucocyte count (R2 = 0.02), p < 0.01 for both. Mortality at 30 days was 3.6%. ROC analyses of the prognostic value of suPAR in relation to 30-day mortality showed that the area under the curve (AUC) was 0.85 (95% CI 0.82-0.87), similar analyses of the triage category showed an AUC of 0.62 (95% c.i. 0.58-0.66). Cox regression analysis of 30-day mortality in relation to suPAR quartiles showed that the hazard ratio for the second quartile was 2.2, third quartile 6.5, and highest quartile 38.4 (p < 0.001). In a multivariable analysis including gender, age, CRP, leucocyte count, and triage category, suPAR remained an independent predictor of 30-day mortality with a hazard ratio for second quartile of 4.5, third quartile 8.3 and highest quartile 26.9.