Skip to main content

Patients hospitalized with severe infections and hypothermia, a cohort study of mortality and prognostic factors


Hypothermia is a predictor of death in patients admitted to the hospital. Although hypothermia is associated with a bad prognosis, the absolute risk in patients admitted with severe infections is unknown.


Prospective follow-up of all patients admitted to a medical emergency department (ED) from 1 August 2009-31 August 2011. Patients were included the first time they presented with severe infection in the study period. Hypothermia was defined as a rectal temperature below 36.0°C. Patients without a measured rectal temperature at arrival were excluded. Severe infections were defined as a discharge diagnosis indicating infection as well as presence of organ failure. To assess whether hypothermia was an independent prognostic factor, we computed multivariable logistic regression analysis, adjusted for different potential confounders.


A total of 3,563 patients presenting with severe infections were included, median age 75 years (5-95% range: 33-92 years), 47.9% were males, 47.9% had Charlson Comorbidity Index>2. 147 (4.1%) presented with hypothermia. The most common site of infection among hypothermic patients with severe infection was the lower respiratory tract (83/147, 56.5%). The crude thirty-day mortality in patients with- and without hypothermia was 27.9% (95% CI: 20.8-35.9%) and 14.4% (95% CI: 13.3-15.7%) respectively. The hazard ratio for 30-day mortality adjusted for sex, age, comorbidity, and number of organ failures was 2.1 (95% CI: 1.4-3.2) compared to patients with severe infections without hypothermia.


Despite only few patients admitted to a medical ED with severe infections were hypothermic at arrival, it is an important clinical finding and independent prognostic factor of short-term mortality.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Christian B Laursen.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Henriksen, D.P., Laursen, C.B. & Lassen, A.T. Patients hospitalized with severe infections and hypothermia, a cohort study of mortality and prognostic factors. Scand J Trauma Resusc Emerg Med 23 (Suppl 1), A27 (2015).

Download citation

  • Published:

  • DOI: