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Table 2 Blood cell count and standard coagulation tests

From: Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study

  FC group FC–PCC group FC–PCC–FFP group p-value
  n   n   n   
Hemoglobin (g/dL)        
ER 85 12.8 (11.2–13.9) 63 11.1 (8.8–12.7) 9 8.4 (6.5–11.6) <0.0001
ICU 70 8.8 (7.8 9.9) 44 9.3 (8.1–10.2) 9 8.0 (7.1–10.0) 0.20
24h 81 8.8 (7.8 9.9) 51 9.3 (8.1–10.2) 4 8.0 (7.1–10.0) 0.27
Platelet count (x 10 9 /L)        
ER 85 210 (176–251) 63 181 (141–215) 9 203 (162–295) 0.041
ICU 54 148 (108–179) 41 104 (65–126) 7 58 (35–88) <0.0001
24h 80 122 (95–162) 51 90 (63–111) 4 58 (37–75) <0.0001
PT (seconds)        
ER 83 14.6 (13.4–15.8) 63 17.0 (15.3–19.3) 9 22.0 (17.7–27.9) <0.0001
ICU 34 17.5 (15.5–19.6) 31 21.0 (17.1–24.3) 7 28.6 (26.6–44.1) <0.0001
24h 70 16.2 (15.2–17.8) 48 16.7 (15.6–18.0) 4 16.6 (16.1–16.7) 0.49
aPTT (seconds)        
ER 82 28.8 (26.0–31.7) 62 33.2 (28.0–43.5) 9 48.8 (35.3–96.5) <0.0001
ICU 42 32.7 (29.9–36.4) 31 46.9 (36.5–54.7) 8 180.0 (89.7–180.0) <0.0001
24h 77 37.7 (33.6–40.4) 49 40.2 (37.2–46.7) 4 45.5 (38.2–49.6) 0.0003
Fibrinogen (mg/dL)        
ER 79 198 (156–225) 60 151 (112–199) 9 95 (83–161) <0.0001
ICU 41 188 (147–219) 32 162 (129–203) 8 119 (82–142) 0.0034
24h 76 266 (236–309) 49 274 (222–316) 4 269 (240–298) 0.96
  1. Data are presented as median (interquartile range) or percentage of patients. p-values are derived from the ANOVA; significance level p < 0.05.
  2. aPTT, activated partial thrombin time; PT, prothrombin time.
  3. FC group, patients receiving fibrinogen concentrate only; FC–PCC group, patients receiving fibrinogen concentrate and prothrombin complex concentrate; FC–PCC–FFP group, patients receiving fibrinogen concentrate, prothrombin complex concentrate and fresh frozen plasma.
  4. Results were obtained at the following timepoints: upon admission to the emergency room (ER), admission to the intensive care unit (ICU) and 24 hours (24h) after ER admission; n = number of patients with available data.