Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study

Table 2 Blood cell count and standard coagulation tests

	FC group		FC–PCC group		FC–PCC–FFP group		p-value
	n		n		n
Hemoglobin (g/dL)
ER	85	12.8 (11.2–13.9)	63	11.1 (8.8–12.7)	9	8.4 (6.5–11.6)	<0.0001
ICU	70	8.8 (7.8– 9.9)	44	9.3 (8.1–10.2)	9	8.0 (7.1–10.0)	0.20
24h	81	8.8 (7.8– 9.9)	51	9.3 (8.1–10.2)	4	8.0 (7.1–10.0)	0.27
Platelet count (x 10 ⁹ /L)
ER	85	210 (176–251)	63	181 (141–215)	9	203 (162–295)	0.041
ICU	54	148 (108–179)	41	104 (65–126)	7	58 (35–88)	<0.0001
24h	80	122 (95–162)	51	90 (63–111)	4	58 (37–75)	<0.0001
PT (seconds)
ER	83	14.6 (13.4–15.8)	63	17.0 (15.3–19.3)	9	22.0 (17.7–27.9)	<0.0001
ICU	34	17.5 (15.5–19.6)	31	21.0 (17.1–24.3)	7	28.6 (26.6–44.1)	<0.0001
24h	70	16.2 (15.2–17.8)	48	16.7 (15.6–18.0)	4	16.6 (16.1–16.7)	0.49
aPTT (seconds)
ER	82	28.8 (26.0–31.7)	62	33.2 (28.0–43.5)	9	48.8 (35.3–96.5)	<0.0001
ICU	42	32.7 (29.9–36.4)	31	46.9 (36.5–54.7)	8	180.0 (89.7–180.0)	<0.0001
24h	77	37.7 (33.6–40.4)	49	40.2 (37.2–46.7)	4	45.5 (38.2–49.6)	0.0003
Fibrinogen (mg/dL)
ER	79	198 (156–225)	60	151 (112–199)	9	95 (83–161)	<0.0001
ICU	41	188 (147–219)	32	162 (129–203)	8	119 (82–142)	0.0034
24h	76	266 (236–309)	49	274 (222–316)	4	269 (240–298)	0.96

Data are presented as median (interquartile range) or percentage of patients. p-values are derived from the ANOVA; significance level p < 0.05.
aPTT, activated partial thrombin time; PT, prothrombin time.
FC group, patients receiving fibrinogen concentrate only; FC–PCC group, patients receiving fibrinogen concentrate and prothrombin complex concentrate; FC–PCC–FFP group, patients receiving fibrinogen concentrate, prothrombin complex concentrate and fresh frozen plasma.
Results were obtained at the following timepoints: upon admission to the emergency room (ER), admission to the intensive care unit (ICU) and 24 hours (24h) after ER admission; n = number of patients with available data.

ISSN: 1757-7241