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Volume 19 Supplement 2

Danish Society for Emergency Medicine: Research Symposium 2011

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Validation of a high-risk versus low-risk referral model in suspected Acute Coronary Syndrome


In future Denmark the majority of acute admissions passes through Emergency and Acute Admission Departments (EAAD). For patients with Acute Coronary Syndrome (ACS) considerable improvements have been achieved through the Cardiac Care Units (CCU). Among patients with acute chest pain only a minority have an ACS. This raises the question if it is possible to separate patients with a high-risk of ACS directly to a CCU, and a low-risk patients to EAAD. The aim of this study was to describe how such a risk stratification would perform.


Retrospective cohort study of patients with suspicion of ACS. If the 1) ECG was normal (apart from atrial fibrillation), no persisting chest pain, no history of IHD, heart failure or an ICD, the patient was considered low-risk and admitted to the EAAD, otherwise to the CCU.


495 patients were admitted, 51 % low risk patients to the EAAD and 49 % with high risk to the CCU. 17 % had a verified ACS. Among ”low risk” patients 10 % and “high risk” 25 % had an ACS (p < 0.0001). In multivariate analysis high risk group, male gender and age above 60 years had a higher risk of ACS. Other combinations of risk factors increased the sensitivity at the expense of predictive value and accuracy.


We believe the model can be useful for future development of referral strategies in acute hospitals in Denmark.

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Correspondence to Christian Backer Mogensen.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mogensen, C.B., Christiansen, M., Jørgensen, J.B. et al. Validation of a high-risk versus low-risk referral model in suspected Acute Coronary Syndrome. Scand J Trauma Resusc Emerg Med 19 (Suppl 2), P51 (2012).

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