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Table 3 Univariate and multivariate contribution of fibrinogen, platelets, FXIII and sCD40L to the variation in TEG maximum amplitude (MA) in trauma patients stratified according to ISS (gr. 2 ISS > 26, gr. 1 ISS 15-26, gr. 0 ISS < 15)

From: Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study

   Univariate Multivariate (model 1) Multivariate (model 2)
  Unit β (SE) p β (SE) p β (SE) p
ISS > 26 (n = 23)     R 2 = 0.47   R 2 = 0.76  
Fibrinogen 1 g/l 6.59 (1.85) 0.002 5.61 (1.86) 0.007 4.65 (1.31) 0.002
Platelets 10 *109/l 0.48 (0.28) 0.094 0.29 (0.25) 0.438 0.42 (0.18) 0.032
FXIII 1% 0.43 (0.20) 0.043 0.24 (0.19) 0.212 0.17 (0.13) 0.210
sCD40L 100 pg/ml -1.62 (0.53) 0.006 - - -1.62 (0.35) < 0.001
ISS 15-26 (n = 26)     R 2 = 0.75   R 2 = 0.76  
Fibrinogen 1 g/l 6.84 (1.08) < 0.001 6.33 (0.96) < 0.001 5.84 (1.04) < 0.001
Platelets 10 *109/l 0.41 (0.20) 0.047 0.37 (0.13) 0.011 0.44 (0.14) 0.006
FXIII 1% 0.13 (0.11) 0.245 0.01 (0.07) 0.847 0.03 (0.07) 0.712
sCD40L 100 pg/ml -0.95 (0.89) 0.300 - - -0.73 (0.61) 0.250
ISS < 15 (n = 30)     R 2 = 0.41   R 2 = 0.41  
Fibrinogen 1 g/l 3.55 (1.12) 0.004 3.26 (1.05) 0.005 3.29 (1.07) 0.005
Platelets 10 *109/l 0.34 (0.13) 0.017 0.30 (1.05) 0.019 0.28 (0.13) 0.038
FXIII 1% 0.00 (0.04) 0.986 0.00 (0.03) 0.995 -0.00 (0.03) 0.984
sCD40L 100 pg/ml 0.38 (0.44) 0.403 - - 0.15 (0.38) 0.691
  1. Univariate and multivariate regression analysis showing regression coefficients (β) with standard errors (SE) and p-values, with p-values in bold for variables with p < 0.05. The β corresponds to the predicted change in TEG MA (mm) associated with one unit increase in fibrinogen, platelet count, FXIII and/or sCD40L.