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Mortality following acute medical hospitalization in Denmark - a population-based cohort study

Background

The age of the general population is increasing: It is estimated that the population aged above 65 years will increase by 400,000 over the next 30 years. A third of this increment is comprised by persons older than 80 years. 45% of the general population and 88% of the population aged above 65 years have at least one chronic disease. Thus, aging of the population is expected to cause an increase in morbidity and an increase in number of hospitalizations. The increasing number of hospitalizations will therefore involve an increasing number of patients with more than one chronic disease. The aim was to examine 1-, 3- and 6-month mortality after acute medical hospitalization according to sex, age, and comorbidity.

Methods

Using data from the Danish National Registry of Patients, we conducted a population-based cohort study including all patients with an admission in 2008 to the Medical Admission Unit (MAU) at Aarhus University Hospital-Nørrebrogade. Only first-time admissions were included. The patients were followed until death, emigration, or 6 months after date of admission using data from the Civil Registration System. Using discharge diagnoses registered before 2008, we ascertained comorbidity and defined three levels of comorbidity index-score (low, medium, high). We examined mortality according to sex, age and comorbidity.

Results

We identified 4,494 patients with a first-time admission in 2008 to MAU. 3,768 (84%) were classified as acute, 252 (6%) as non-acute, and 474 (11%) were unclassified. Among the patients with acute admissions, 54% were women and 45% men. The median age was 63 years for women and 60 for men. 45% of the patients had a low comorbidity index-score, 33% had a medium index-score and 22% had a high index-score. Overall mortality was 5.5% after 30 days, 9.3% after 90 days, and 12.6% after 6 months. Mortality of patients older than 80 years was 13.9%, 23.4%, and 29.5%, respectively. Patients with the high comorbidity index-score had a mortality of 11.9%, 20.4%, and 26.9%, respectively.

Conclusion

Mortality after admission with an acute medical disease was strongly associated with age and comorbidity, but did not vary by sex.

Author information

Correspondence to Betina Hansen.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • General Population
  • Chronic Disease
  • National Registry
  • Registration System
  • Discharge Diagnosis