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Table 1 Summary of Important Trials Published*

From: The contemporary role of blood products and components used in trauma resuscitation

Author and Year Patient Group rFVIIa Dosing Primary Endpoint Outcomes
Boffard; [67] J Trauma 2005; 59:8-18 Penetrating and blunt trauma (301) 200+100+100 μg/kg RBC units first 24 hours Reduction in RBCs (blunt)
Raobaikady; [68] Br J Anaesth 2005; 94:586-591 Pelvic fractures (48) 90 μg/kg Perioperative blood loss No difference
Hauser; [69] J Trauma 2010; 69:489-500 Blunt and penetrating trauma (573) 200+100+100 μg/kg Mortality, blood product use No mortality difference, Less product use
Wade; [70] J Trauma 2010; 69:353-359** Military trauma (2,050) Varied Complications, mortality No difference
  1. *Modified from Ann Emerg Med 2009; 54:737-744.
  2. **Large retrospective case control analysis.