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Table 1 Toxidromes

From: Management of the critically poisoned patient

Toxidrome Site of Action Signs and symptoms
Opioid opioid receptor sedation, miosis, decreased bowel sounds, decreased respirations
Anticholinergic muscurinic acetylcholine receptors altered mental status, sedation, hallucinations, mydriasis, dry skin, dry mucous membranes, decreased bowel sounds and urinary retention
Sedative-hypnotic gamma-aminobutyric acid receptors sedation, normal pupils, decreased respirations
Sympathomimetic alpha and beta adrenergic receptors agitation, mydriasis, tachycardia, hypertension, hyperthermia, diaphoresis
Cholinergic nicotinic and muscurinic acetylcholine receptors altered mental status, seizures, miosis, lacrimation, diaphoresis, bronchospasm, bronchorrhea, vomiting, diarrhea, bradycardia
Serotonin syndrome serotonin receptors altered mental status, tachycardia, hypertension, hyperreflexia, clonus, hyperthermia