Skip to main content

Table 3 Diagnostic accuracy measures with 95% confidence intervals of presumptive diagnoses before and after POCUS

From: PrehospitaL Ultrasound in Undifferentiated DyspnEa (PreLUDE): a prospective, clinical, observational study

 

ROC AUC

Sens

Spec

PPV

NPV

LR + 

LR-

Before POCUS

Acute heart failure (valid* n = 185)

0.72 (0.66–0.78)

57.5% (46–68)

86.7% (79–93)

76.7% (64–87)

72.8% (64–80)

4.31 (2.56–7.27)

0.49 (0.38–0.64)

AE-COPD/AE-asthma (valid* n = 202)

0.87 (0.82–0.91)

93.8% (85–98)

80.3% (72.6–86.6)

68.2% (57–78)

96.5% (91–99)

4.62 (3.3–6.47)

0.08 (0.03–0.2)

Pneumonia (valid* n = 172)

0.67 (0.59–0.76)

57.5% (41–73)

77.3% (69–84)

43.4% (30–58)

85.7% (78–92)

2.53 (1.68–3.82)

0.55 (0.38–0.8)

Pulmonary embolism (valid* n = 167)

0.66 (0.42–0.90)

40.0% (5–85)

92% (87–96)

13.3% (2–41)

98.0% (94–100)

4.98 (1.51–16.44)

0.65 (0.32–1.34)

Pneumothorax (valid* n = 183)

0.72 (0.23–1.0)

50.0% (1–99)

93.4% (89–97)

7.7% (0–36)

99.4% (97–100)

7.54 (1.7–33.46)

0.54(0.13–2.14)

After POCUS

Acute heart failure (valid* n = 194)

0.79 (0.73–0.84)

65.0% (54–75)

92.1% (86–96)

85.2% (74–93)

78.9% (71–86)

8.23 (4.31–15.73)

0.38 (0.28–0.51)

AE-COPD/AE-asthma (valid* n = 200)

0.93 (0.88–0.97)

90.3% (80–96)

94.9% (90–98)

88.9% (78–95)

95.6% (91–98)

17.81 (8.61–36.82)

0.1 (0.05–0.22)

Pneumonia (valid* n = 170)

0.66 (0.58–0.74)

50% (35–65)

82.5% (75–89)

50% (35–65)

82.5% (75–89)

2.86 (1.77–4.63)

0.61 (0.45–0.82)

Pulmonary embolism (valid* n = 187)

0.61 (0.37–0.86)

25.0% (1–81)

97.8% (95–99)

20.0% (1–72)

98.4% (95–100)

11.44 (1.62–80.76)

0.77 (0.44–1.35)

Pneumothorax (valid* n = 210)

0.75 (0.26–1.0)

50.0% (1–99)

99.5% (97–100)

50% (1–99)

99.5% (97–100)

104 (9.47–1142.53)

0.50 (0.13–2.01)

  1. *valid n is the number of patients with presumptive diagnoses before/after POCUS registered as yes/no (not "unknown") and endpoint committee adjudicated to yes/no (not "unknown")