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Table 2 IC50-values for inhibition of phosphodiesterase-3 (PDE3), phosphodiesterase-5 (PDE5), and inhibition of cAMP- and cGMP-efflux at temperatures ranging from 37 to 20 °C

From: Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Temperature

PDE3

PDE5

cAMP-efflux

cGMP-efflux

37 °C

15.8 ± 4.25

7.70 ± 0.265

1.33 ± 0.566

0.531 ± 0.338

34 °C

14.2 ± 1.51

10.7 ± 1.92

3.61 ± 2.59

0.893 ± 0.401

32 °C

26.7 ± 4.70

15.5 ± 0.753

2.01 ± 0.819

0.724 ± 0.206

28 °C

22.4 ± 6.36

24.3 ± 5.58

1.93 ± 1.11

0.851 ± 0.281

24 °C

29.2 ± 4.72

25.2 ± 6.57

–

0.502 ± 0.315

20 °C

31.0 ± 9.47

39.4 ± 10.9*

–

0.388 ± 0.070

  1. Values are mean ± SEM and given in µM. * Significant difference (p-value < 0.05), when compared to normothermic baseline. No inhibition of ABCC4-activity was detectable below 28 °C
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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

ISSN: 1757-7241