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Table 1 Values depicting intracellular availability of pentoxifylline at temperatures ranging from 37 to 20 °C

From: Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Intracellular availability

Pentoxifylline (nmol/g protein)

Pentoxifylline [% of added (drug)/g protein]

37 °C

17.7 ± 3.07

0.15 ± 0.021

34 °C

11.5 ± 0.755

0.15 ± 0.005

32 °C

21.5 ± 3.28

0.15 ± 0.018

28 °C

15.2 ± 2.19

0.15 ± 0.021

24 °C

31.5 ± 8.22

0.13 ± 0.018

20 °C

12.1 ± 3.07

0.12 ± 0.011

  1. Values are mean ± SEM. No significant change from 37 °C was detected for either absolute concentration nor %-difference
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