Fig. 6From: Fluid resuscitation with balanced crystalloids versus normal saline in critically ill patients: a systematic review and meta-analysisTrial sequential analysis for mortality of non-TBI patients. TSA used estimates of 21.9% for baseline mortality, 5% for relative risk reduction, 5% for alpha and 80% for power.The sample size not reached required information size, but Z-curve crossed conventional boundary and TSA boundaryBack to article page