From: Which injured patients with moderate fibrinogen deficit need fibrinogen supplementation?
Study group | Shock index > 1.0 | Hemoglobin < 110 g L−1 | Base deficit > 5.0 mEq L−1 | Fibrinogen administration | ||||
---|---|---|---|---|---|---|---|---|
No | Yes | No | Yes | No | Yes | No | Yes | |
N | 211 (80) | 54 (20) | 195 (74) | 67 (26) | 133 (56) | 106 [44] | 144 (54) | 122 (46) |
Demographic data | ||||||||
 Age (years) | 31 [22–50] | 28 [22–46] | 28 [21–45] | 42* [25–65] | 29 [21–49] | 35 [23–50] | 33 [22–50] | 28 [22–46] |
 ISS | 25 [18–33] | 29 [17–38] | 24 [17–30] | 27* [18–41] | 24 [17–29] | 29* [22–38] | 24* [17–29] | 27 [19–36] |
Prehospital parameters | ||||||||
 GCS | 14 [8–15] | 14 [7–15] | 15 [9–15] | 14* [7–15] | 14 [9–15] | 13* [6–15] | 14 [10–15] | 14 [6–15] |
 SBP (mmHg) | 122 [104–137] | 115 [96–130] | 123 [108–138] | 110* [80–132] | 125 [108–140] | 114* [94–131] | 123 [105–138] | 118 [100–134] |
 Fluids (mL) | 1000 [500–150] | 1375* [1000–1563] | 1000 [500–1500] | 1250* [1000–1500] | 750 [500–1250] | 1250* [750–1500] | 1000 [500–1500] | 1000 [600–1500] |
Admission parameters | ||||||||
 SBP (mmHg) | 121 [108–135] | 90* [77–102] | 120 [103–134] | 101* [87–123] | 120 [107–135] | 111* [90–132] | 116 [101–133] | 116 [95–134] |
 Shock Index | 0.7 [0.6–0.9] | 1.3* [1.1–1.5] | 0.8 [0.6–1.0] | 0.9* [0.7–1.1] | 0.7 [0.6–0.9] | 0.9* [0.7–1.1] | 0.8* [0.6–1.0] | 0.8 [0.7–1.1] |
 Base deficit (mEq L−1] | 4.3 [2.3–6.1] | 6.9* [4.6–10.8] | 3.8 [2.3–5.8] | 6.9* [4.7–8.9] | 2.8 [1.9–3.9] | 7.3* [5.9–9.2] | 3.8* [2.0–6.1] | 5.4 [3.6–7.8] |
 Hemoglobin (g L−1) | 127 [113–140] | 115* [93–126] | 129 [121–141] | 94* [86–106] | 127 [116–141] | 119* [101–131] | 127* [115–140] | 120 [101–133] |
 PTratio | 1.2 [1.1–1.3] | 1.2* [1.1–1.4] | 1.1 [1.1–1.2] | 1.3* [1.2–1.4] | 1.1 [1.1–1.2] | 1.2* [1.1–1.3] | 1.1* [1.1–1.2] | 1.2 [1.1–1.3] |
 Fibrinogen (g L−1) | 1.8 [1.6–1.9] | 1.7* [1.6–1.8] | 1.8 [1.6–1.9] | 1.8 [1.6–1.9] | 1.8 [1.6–1.9] | 1.7* [1.6–1.8] | 1.8* [1.7–1.9] | 1.7 [1.6–1.8] |
 Platelet (109 L−1) | 219 [184–258] | 226 [183–290] | 225 [188–271] | 208* [154–246] | 221 [188–258] | 213 [175–277] | 225 [189–271] | 210 [179–255] |
Red blood cell (unit) | 0.0 [0.0–0.0] | 1.5* [0.0–3.0] | 0.0 [0.0–0.0] | 2.0* [0.0–4.0] | 0.0 [0.0–0.0] | 0.0* [0.0–2.0] | 0.0* [0.0–0.0] | 1.0 [0.0–3.0] |
Fibrinogen concentrate | ||||||||
 (g) | 0.0 [0.0–0.0] | 1.5* [0.0–3.0] | 0.0 [0.0–0.0] | 2.0* [0.0–3.0] | 0.0 [0.0–2.0] | 1.5* [0.0–3.0] | – | 3.0 [1.5–3.0] |
 N (%) | 90 (43) | 32* (59) | 78 (40) | 42* (63) | 47 (35) | 63* (59) | – | – |