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Table 3 Test characteristics of different trigger factors in the internal validation cohort

From: Identification and validation of objective triggers for initiation of resuscitation management of acutely ill non-trauma patients: the INITIATE IRON MAN study

Trigger factor AUC (range) Sensitivity, % Specificity, % PPV, % NPV, %
qSOFA ≥ 2 points 0.56 (0.48–0.64) 11.8 100 100 93.9
NEWS ≥ 7 points 0.66 (0.58–0.74)* 32.4 99.9 95.7 95.3
Iteration 1 0.92 (0.87–0.97)* 85.3 98.7 82.9 98.9
Iteration 2 0.91 (0.86–0.97)* 83.8 98.9 85.1 98.8
Iteration 3 0.99 (0.97–1.00)* 98.5 98.6 83.3 99.9
  1. AUC, area under the receiver operating characteristics curve; NEWS, National Early Warning Score; NPV, negative predictive value; PPV, positive predictive value; qSOFA, Quick Sequential Organ Failure Assessment Score
  2. *p < 0.0001