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Table 3 Subgroup analysis results for the primary outcome considering variability in outcome assessment and age

From: Incidence of delayed bleeding in patients on antiplatelet therapy after mild traumatic brain injury: a systematic review and meta-analysis

Study Repeated CT scan Follow-up Age ≥ 60 yo Age < 60 yo
ANTONI_2019 1.85% (0.23–6.53%) NA NA 1.85% (0.23–6.53%)
BATTLE_2017 2.27% (0.06–12.02%) NA 2.27% (0.06–12.02%) NA
CHENOWETH_2018 NA 0.00% (0.00–1.92%) NA 0.00% (0.00–1.92%)
ERNSTBRUNNER_2016 1.05% (0.29–2.66%) NA 1.05% (0.29–2.66%) NA
GALLIAZZO_2019 1.53% (0.19–5.41%) NA NA 1.53% (0.19–5.41%)
GANETSKY_2017 NA 0.16% (0.00–0.87%) NA 0.16% (0.00–0.87%)
HILL_2018 3.29% (1.33–6.65%) NA NA 3.29% (1.33–6.65%)
HUANG_2019 2.52% (0.52–7.19%) NA NA 2.52% (0.52–7.19%)
MANN_2018 0.00% (0.00–3.18%) NA 0.00% (0.00–3.18%) NA
NISHIJIMA_2012 NA 0.00% (0.00–1.53%) NA 0.00% (0.00–1.53%)
PECK_2011 NA 0.00% (0.00–3.52%) NA 0.0% (0.00–3.52%)
SCANTLING_2017 1.21% (0.15–4.28%) NA 1.21% (0.15–4.31%) NA
STANITSAS_2016 0.00% (0.00–8.81%) NA NA 0.05 (0.00–8.81%)
SWAP_2016 NA 2.31% (0.85–4.95%) NA 2.31% (0.85–4.95%)
TAUBER_2009 4.00% (1.10–9.93%) NA 4.0% (1.10–9.93%) NA
TAYLOR_2012 0.00% (0.00–4.25%) NA NA 0.00% (0.00–4.25%)
No. studies 11 5 5 11
DB mean estimated risk 1.29% (0.66–2.18%) 0.22% (0.00–1.05%) 1.09% (0.18–2.52%) 0.64% (0.07–1.57%)
p value for heterogeneity p = 0.2011 p = 0.0207 p = 0.1491 p = 0.0008
I2 statistic 26% 66% 41% 67%
  1. The results are presented as the mean estimates of delayed bleeding risk and 95% confidence intervals (in parentheses). Repeated CT scan: delayed bleeding detection by means of a routine repeated CT scan; Follow-up = event detection by means of a clinical follow-up; Age ≥ 60 yo = only studies enrolling patients older than 60 years old are included; Age < 60 yo = only studies enrolling patients younger than 60 years old are included; No. studies = number of the studies included in the analysis; NA = not assessed in the corresponding original study