- Airway – loss of airway patency | |
- Breathing – inadequate ventilation, respiratory failure or hypoxia | |
- Circulation – improve oxygen delivery in hypovolaemia or allow haemorrhage control procedures | |
- Disability – neuroprotection particularly in traumatic brain injury, reduced Glasgow Coma Score, status epilepticus, post cardiac arrest protection | |
- Everything else – e.g. emergency surgery, humanitarian indications, temperature control (e.g. serotonin syndrome), to facilitate safe transfer. |