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Table 4 Analysis of viscoelastic parameters in albumin-based colloid solutions enriched with factor XIII (FXIII), prothrombin complex concentrate (PCC) and fibrinogen (FGN). Different FXIII concentrations (0.1, 0.5, 1, 2, 4, 8 IU/ml) were combined with fixed PCC and FGN concentrations of 1 IU/ml and 4 g/l, respectively. The albumin concentration was maintained stable at 5%. Negative controls for FXIII- free solutions are represented by the corresponding compositions shown in Tables 2 and 3. A minimum of three repeats for each concentration step was performed. The values in bold letters reflect the optimal FXIII response for CRF composition

From: Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Increasing FXIII concentrations over PCC 1 IU/ml and FGN 4 g/l
FXIII conc. a 0.1 0.5 1 2 4 8
CTb,* 123 ± 12.7 128 ± 17.3 135.3 ± 12.7 122.3 ± 7.5 133.5 ± 29 133.3 ± 22.2
A10c,** 12.5 ± 0.7 16.3 ± 1.5 21.3 ± 2.1 24.3 ± 2.3 30.3 ± 11.4 30.7 ± 9.9
MCFc,*** 13.5 ± 0.7 18.7 ± 2.1 23.7 ± 3.1 26.7 ± 4.6 32.3 ± 10.4 35.7 ± 12.4
  1. *no correlation, **p = 0,004, Pearson rho 0,65, ***p = 0,002, Pearson rho 0,69
  2. aFXIII concentrations in IU/ml
  3. bCT in seconds. Mean values ± SD
  4. cA10 and MCF in mm. Mean values ± SD
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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

ISSN: 1757-7241

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