Intraosseous versus intravenous vascular access during cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of observational studies

Hsieh, Yu-Lin; Wu, Meng-Che; Wolfshohl, Jon; d’Etienne, James; Huang, Chien-Hua; Lu, Tsung-Chien; Huang, Edward Pei-Chuan; Chou, Eric H.; Wang, Chih-Hung; Chen, Wen-Jone

doi:10.1186/s13049-021-00858-6

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Table 1 Characteristics of the studies identified in the systematic review

From: Intraosseous versus intravenous vascular access during cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of observational studies

First author, publication year	Study period/ region	Patient number	Main population characteristics						Selection of intervention and comparator	EMS^e response time, mean or median (min)	Time to intervention adjusted in analysis
First author, publication year	Study period/ region	Patient number	Inclusion criteria	Age, mean or median	Male, %	Witnessed arrest, %	Bystander CPR,^b %	Shockable rhythms, %	Selection of intervention and comparator	EMS^e response time, mean or median (min)	Time to intervention adjusted in analysis
Clemency et al., 2017 [17]	2013–2015/ USA	1340	Adult OHCA^a	62	64	49	27	15	First attempted IO^c and IV^d access	NA	No
Feinstein et al., 2017 [18]	2012–2014/ USA	1800	Adult non-traumatic OHCA	64	63	57	69	28	Actual IO and IV access for drug use	5.9	Yes (time to establishment of vascular access adjusted)
Kawano et al., 2018 [19]	2007–2009/ USA & Canada	13,155	Adult non-traumatic OHCA	68	66	52	38	26	First attempted IO and IV access	5.5	No
Mody et al., 2019 [20]	2011–2015/ USA & Canada	19,731	Adult non-traumatic OHCA	68	65	24	46	22	First attempted IO and IV access	5.4	Yes (time to medications administration adjusted)
Nguyen et al., 2019 [21]	2013–2017/ USA	795	Adult non-traumatic OHCA	65	62	NA	NA	21	First attempted IO and IV access	12.9	No
Baert et al., 2020 [22]	2011–2017/ France	28,856	Adult non-traumatic OHCA	67	70	73	50	13	Actual IO and IV access for drug use	10	Yes (time to medications administration adjusted)
Daya et al., 2020 [23]	2012–2015/ USA & Canada	3019	Adult non-traumatic OHCA	63	80	70	57	100	Actual IO and IV access for drug use	5.7	Yes (time to establishment of vascular access adjusted)
Nolan et al., 2020 [24]	2014–2017/ UK	7317	Adult non-traumatic OHCA	70	65	61	59	18	Actual IO and IV access for drug use	7.4	No
Zhang et al., 2020 [25]	2011–2015/ USA & Canada	35,733	Adult non-traumatic OHCA	66	66	48	44	22	First attempted IO and IV access	5.1	Yes (time to establishment of vascular access adjusted)

^aOHCA out-of-hospital cardiac arrest
^bCPR cardiopulmonary resuscitation
^cIO intraosseous
^dIV intravenous
^eEMS emergency medical service

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ISSN: 1757-7241

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