Fig. 2

Platelet count (a) and platelet activation after concentration dependent PDMP (n = 7) (b) and EDMP (n = 4) (c) supplementation under the simulated conditions of whole blood (WB), haemodilution (HD) and Lethal Triad (LT). Platelet activation was measured by expression levels of CD42b⁺/CD62p⁺ on platelets surface. Results are presented as relative changes referring to the respective unstimulated approach of each experimental group. Values are presented as mean/median ± SD (a) or as Tukey boxplots with whiskers of length 1.5 x IQR (b, c). Statistical significances were marked with asterisks for concentration-dependent differences within one experimental group (*^,+p ≤ 0.05, **^,++p ≤ 0.01, ***^,+++p ≤ 0.001), respectively. The abbreviation k signifies a thousand