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Table 4 Comparison of number of deaths due to bleeding avoided by tranexamic acid treatment

From: Validation of the BATT score for prehospital risk stratification of traumatic haemorrhagic death: usefulness for tranexamic acid treatment criteria

 

Patients treated N (%) N = 104,862

Deaths avoided N (95% CI)

Deaths avoided per 10,000 patients N (95% CI)

Number needed to treat to avoid one death

Based on predicted probabilities

 Current strategya

9915 (11)

55 (54–57)

5 (5–5)

180

 All prehospital

79,430 (76)

224 (220–228)

21 (21–22)

355

 All in hospital

63,246 (60)

146 (144–149)

14 (14–14)

430

Based on observed probabilities (sensitivity analysis)b

 Current strategya

9915 (11)

168 (157–178)

16 (15–17)

59

 All prehospital

79,430 (76)

323 (305–341)

31 (29–33)

244

 All in hospital

63,246 (60)

240 (226–253)

22 (21–24)

273

  1. NNT Number Needed to Treat
  2. aCurrent strategy observed in the UK-TARN data based on clinical judgment and current guidelines in UK
  3. bSensitivity analysis based on observed deaths due to bleeding