The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

He, Yong; Wang, Guoxing; Li, Chuang; Wang, Yuxing; Zhang, Qian

doi:10.1186/s13049-020-00819-5

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Table 4 Arterial blood gasses

From: The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

Group	Parameter	Baseline	ROSC 0 min	ROSC 30 min	ROSC 1 h	ROSC 2 h	ROSC 4 h	ROSC 6 h
SA group	PH	7.41 ± 0.11	7.14 ± 0.05^**	7.18 ± 0.07^**	7.20 ± 0.06^**	7.27 ± 0.09^*	7.30 ± 0.08^*	7.32 ± 0.09^*
	PaO₂ (mm Hg)	89.1 ± 9.3	44.5 ± 4.7^**	55.4 ± 5.1^**	60.1 ± 6.2^**	70.2 ± 7.1^**	79.5 ± 7.7^*	80.7 ± 7.5^*
	PaCO₂ (mm Hg)	39.3 ± 3.2	48.3 ± 5.1^**	46.7 ± 5.4^**	45.4 ± 4.1^**	43.8 ± 4.7^*	41.6 ± 4.2	41.5 ± 4.8
	HCO₃(mmol/L)	27.2 ± 4.7	19.3 ± 1.2^**	20.4 ± 1.6^**	21.6 ± 2.7^**	22.7 ± 2.6^**	24.5 ± 3.1^*	25.2 ± 3.7
	LAC (mmol/L)	2.6 ± 0.5	11.2 ± 3.3^**	9.3 ± 2.7^**	8.8 ± 1.9^**	6.9 ± 2.2^**	5.8 ± 1.3^*	4.7 ± 1.1^*
Sildenafil group	PH	7.42 ± 0.13	7.27 ± 0.07^**Δ#	7.29 ± 0.04^**Δ#	7.30 ± 0.07^*Δ#	7.32 ± 0.05^*	7.35 ± 0.04	7.38 ± 0.11
	PaO₂ (mm Hg)	90.2 ± 8.6	52.7 ± 5.3^**Δ#	63.5 ± 6.2^**Δ#	70.3 ± 7.1^**Δ#	79.3 ± 7.7^*Δ#	83.5 ± 8.1^*	84.9 ± 8.2
	PaCO₂ (mm Hg)	39.5 ± 3.4	44.7 ± 4.3^**Δ#	43.2 ± 4.4^*Δ#	42.4 ± 4.1^*Δ#	41.3 ± 4.2	40.5 ± 4.2	41.1 ± 3.8
	HCO₃ (mmol/L)	27.6 ± 4.1	22.6 ± 2.7^**Δ#	23.7 ± 2.6^**Δ#	24.6 ± 2.7^*Δ#	25.3 ± 2.6	25.7 ± 3.1	26.3 ± 3.8
	LAC (mmol/L)	2.7 ± 0.4	8.5 ± 2.4^**Δ#	8.1 ± 2.1^**Δ#	7.4 ± 1.6^**Δ#	5.3 ± 1.3^**Δ	4.2 ± 1.2^*	3.6 ± 0.7
Sildenafil + LNANE group	PH	7.41 ± 0.13	7.19 ± 0.06^**Δ	7.21 ± 0.06^**Δ	7.23 ± 0.04^**Δ	7.29 ± 0.09^**	7.31 ± 0.07^**	7.34 ± 0.07^*
	PaO₂ (mm Hg)	90.1 ± 9.1	46.4 ± 3.7^**	58.5 ± 4.3^**	63.1 ± 6.2^**	72.2 ± 7.1^**	80.5 ± 7.7^*	80.9 ± 7.3^*
	PaCO₂ (mm Hg)	39.4 ± 3.3	47.8 ± 4.4^**	46.3 ± 4.3^**	44.6 ± 4.5^**	43.2 ± 4.1^*	42.3 ± 3.3	41.3 ± 4.2
	HCO₃ (mmol/L)	27.4 ± 4.3	20.5 ± 2.4^**	21.7 ± 2.5^**	21.6 ± 2.7^**	22.7 ± 2.6^**	23.8 ± 3.2^*	25.4 ± 3.6
	LAC (mmol/L)	2.6 ± 0.4	10.8 ± 4.5^**	9.8 ± 3.5^**	8.8 ± 1.9^**	6.9 ± 2.2^**	5.8 ± 1.3^*	4.1 ± 2.3

Values are mean ± SD (n)
^*p < 0.05 vs. baseline, ^**p < 0.01 vs. baseline, ^Δ P < 0.05 vs. SA.^# P < 0.05 vs. Sildenafil+L-NAME group. (Student t test was used for comparisons between every two groups. Partial pressures are given in mmHg. HCO₃: bicarbonate in mM; Differences at different time points were compared with repeated-measures analysis of variance (ANOVA) with Bon-ferroni correction for post hoc comparison between multiple experimental groups)

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