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Table 4 Arterial blood gasses

From: The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

Group Parameter Baseline ROSC 0 min ROSC 30 min ROSC 1 h ROSC 2 h ROSC 4 h ROSC 6 h
SA group PH 7.41 ± 0.11 7.14 ± 0.05** 7.18 ± 0.07** 7.20 ± 0.06** 7.27 ± 0.09* 7.30 ± 0.08* 7.32 ± 0.09*
PaO2 (mm Hg) 89.1 ± 9.3 44.5 ± 4.7** 55.4 ± 5.1** 60.1 ± 6.2** 70.2 ± 7.1** 79.5 ± 7.7* 80.7 ± 7.5*
PaCO2 (mm Hg) 39.3 ± 3.2 48.3 ± 5.1** 46.7 ± 5.4** 45.4 ± 4.1** 43.8 ± 4.7* 41.6 ± 4.2 41.5 ± 4.8
HCO3(mmol/L) 27.2 ± 4.7 19.3 ± 1.2** 20.4 ± 1.6** 21.6 ± 2.7** 22.7 ± 2.6** 24.5 ± 3.1* 25.2 ± 3.7
LAC (mmol/L) 2.6 ± 0.5 11.2 ± 3.3** 9.3 ± 2.7** 8.8 ± 1.9** 6.9 ± 2.2** 5.8 ± 1.3* 4.7 ± 1.1*
Sildenafil group PH 7.42 ± 0.13 7.27 ± 0.07**Δ# 7.29 ± 0.04**Δ# 7.30 ± 0.07*Δ# 7.32 ± 0.05* 7.35 ± 0.04 7.38 ± 0.11
PaO2 (mm Hg) 90.2 ± 8.6 52.7 ± 5.3**Δ# 63.5 ± 6.2**Δ# 70.3 ± 7.1**Δ# 79.3 ± 7.7*Δ# 83.5 ± 8.1* 84.9 ± 8.2
PaCO2 (mm Hg) 39.5 ± 3.4 44.7 ± 4.3**Δ# 43.2 ± 4.4*Δ# 42.4 ± 4.1*Δ# 41.3 ± 4.2 40.5 ± 4.2 41.1 ± 3.8
HCO3 (mmol/L) 27.6 ± 4.1 22.6 ± 2.7**Δ# 23.7 ± 2.6**Δ# 24.6 ± 2.7*Δ# 25.3 ± 2.6 25.7 ± 3.1 26.3 ± 3.8
LAC (mmol/L) 2.7 ± 0.4 8.5 ± 2.4**Δ# 8.1 ± 2.1**Δ# 7.4 ± 1.6**Δ# 5.3 ± 1.3**Δ 4.2 ± 1.2* 3.6 ± 0.7
Sildenafil + LNANE group PH 7.41 ± 0.13 7.19 ± 0.06**Δ 7.21 ± 0.06**Δ 7.23 ± 0.04**Δ 7.29 ± 0.09** 7.31 ± 0.07** 7.34 ± 0.07*
PaO2 (mm Hg) 90.1 ± 9.1 46.4 ± 3.7** 58.5 ± 4.3** 63.1 ± 6.2** 72.2 ± 7.1** 80.5 ± 7.7* 80.9 ± 7.3*
PaCO2 (mm Hg) 39.4 ± 3.3 47.8 ± 4.4** 46.3 ± 4.3** 44.6 ± 4.5** 43.2 ± 4.1* 42.3 ± 3.3 41.3 ± 4.2
HCO3 (mmol/L) 27.4 ± 4.3 20.5 ± 2.4** 21.7 ± 2.5** 21.6 ± 2.7** 22.7 ± 2.6** 23.8 ± 3.2* 25.4 ± 3.6
LAC
(mmol/L)
2.6 ± 0.4 10.8 ± 4.5** 9.8 ± 3.5** 8.8 ± 1.9** 6.9 ± 2.2** 5.8 ± 1.3* 4.1 ± 2.3
  1. Values are mean ± SD (n)
  2. *p < 0.05 vs. baseline, **p < 0.01 vs. baseline, Δ P < 0.05 vs. SA.# P < 0.05 vs. Sildenafil+L-NAME group. (Student t test was used for comparisons between every two groups. Partial pressures are given in mmHg. HCO3: bicarbonate in mM; Differences at different time points were compared with repeated-measures analysis of variance (ANOVA) with Bon-ferroni correction for post hoc comparison between multiple experimental groups)