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Table 3 Haemodynamics during cardiopulmonary resuscitation and ROSC

From: The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

Group Parameter Baseline ROSC 0 min ROSC 30 min ROSC 1 h ROSC 2 h ROSC 4 h ROSC 6 h
SA group HR 101.3 ± 8.30 132.2 ± 11.3** 129.4 ± 10.4** 120.3 ± 8.9** 118.9 ± 9.3** 113.5 ± 17.4* 101.4 ± 10.4
CO 2.99 ± 0.20 0.91 ± 0.07** 0.88 ± 0.06** 0.89 ± 0.06** 0.91 ± 0.05** 1.04 ± 0.05** 1.15 ± 0.04**
MAP 91.88 ± 3.22 125.2 ± 7.3** 122.5 ± 6.4** 115.4 ± 6.1** 109.8 ± 5.7** 107.6 ± 5.1** 101.5 ± 4.8*
CPP 44.2 ± 4.12 22.3 ± 2.5** 23.4 ± 2.6** 25.6 ± 2.7** 29.7 ± 3.6** 32.5 ± 3.8* 33.8 ± 3.7*
MPAP 24.1 ± 2.2 49.7 ± 6.3** 47.3 ± 5.7** 43.8 ± 4.7** 39.7 ± 4.2** 35.8 ± 3.7* 35.1 ± 3.1*
Sildenafil group HR 102.1 ± 7.30 123.2 ± 9.3**Δ# 118.4 ± 8.4**Δ# 115.3 ± 7.9** 110.9 ± 6.3*Δ# 107.5 ± 5.4Δ# 105.4 ± 4.4
CO 2.99 ± 0.20 0.99 ± 0.06** 1.12 ± 0.03** 1.23 ± 0.04**Δ# 1.34 ± 0.08**Δ# 1.42 ± 0.07**Δ# 1.36 ± 0.08**
MAP 89.88 ± 3.22 117.2 ± 7.1**Δ# 115.5 ± 5.9**Δ# 111.8 ± 5.6** 103.6 ± 4.7**Δ# 99.8 ± 4.3*Δ# 94.5 ± 3.4
CPP 43.1 ± 3.34 27.6 ± 2.8**Δ 28.2 ± 2.9**Δ 32.4 ± 3.1** 35.4 ± 3.6*Δ# 36.5 ± 3.9Δ# 39.4 ± 4.3Δ
MPAP 24.6 ± 2.7 40.3 ± 5.6**Δ# 38.4 ± 4.1**Δ# 37.8 ± 4.1**Δ# 33.6 ± 3.5 29.8 ± 3.1Δ 28.7 ± 2.2Δ
Sildenafil + L-NANE group HR 103.2 ± 7.22 128.4 ± 9.1** 125.6 ± 7.3 118.5 ± 7.2* 115.9 ± 6.6 112.6 ± 5.7Δ 104.7 ± 6.4
CO 2.99 ± 0.20 0.98 ± 0.07** 0.87 ± 0.05** 0.92 ± 0.06** 0.98 ± 0.04** 1.17 ± 0.05** 1.21 ± 0.06**
MAP 88.18 ± 3.22 121.2 ± 6.1**Δ 120.6 ± 7.4** 117.4 ± 6.4** 113.8 ± 6.7** 110.7 ± 4.6** 99.7 ± 4.6*
CPP 44.2 ± 3.52 24.8 ± 2.7**Δ 25.7 ± 2.8** 27.7 ± 2.6** 30.6 ± 3.2** 32.7 ± 3.6* 35.7 ± 3.4*
MPAP 24.6 ± 2.7 45.2 ± 5.4**Δ 46.2 ± 5.3** 44.7 ± 4.3** 38.4 ± 4.7** 36.9 ± 3.5* 34.3 ± 3.6*
  1. Values are mean ± SD (n)
  2. *p < 0.05 vs. baseline, **p < 0.01 vs. baseline, Δ P < 0.05 vs. SA group. # p < 0.05 vs. Sildenafil+L-NAME group. (Student t test was used for comparisons between every two groups. Partial pressures are given in mmHg. HCO3: bicarbonate in mM; Differences at different time points were compared with repeated-measures analysis of variance (ANOVA) with Bon-ferroni correction for post hoc comparison between multiple experimental groups)