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Table 3 Haemodynamics during cardiopulmonary resuscitation and ROSC

From: The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

Group

Parameter

Baseline

ROSC 0 min

ROSC 30 min

ROSC 1 h

ROSC 2 h

ROSC 4 h

ROSC 6 h

SA group

HR

101.3 ± 8.30

132.2 ± 11.3**

129.4 ± 10.4**

120.3 ± 8.9**

118.9 ± 9.3**

113.5 ± 17.4*

101.4 ± 10.4

CO

2.99 ± 0.20

0.91 ± 0.07**

0.88 ± 0.06**

0.89 ± 0.06**

0.91 ± 0.05**

1.04 ± 0.05**

1.15 ± 0.04**

MAP

91.88 ± 3.22

125.2 ± 7.3**

122.5 ± 6.4**

115.4 ± 6.1**

109.8 ± 5.7**

107.6 ± 5.1**

101.5 ± 4.8*

CPP

44.2 ± 4.12

22.3 ± 2.5**

23.4 ± 2.6**

25.6 ± 2.7**

29.7 ± 3.6**

32.5 ± 3.8*

33.8 ± 3.7*

MPAP

24.1 ± 2.2

49.7 ± 6.3**

47.3 ± 5.7**

43.8 ± 4.7**

39.7 ± 4.2**

35.8 ± 3.7*

35.1 ± 3.1*

Sildenafil group

HR

102.1 ± 7.30

123.2 ± 9.3**Δ#

118.4 ± 8.4**Δ#

115.3 ± 7.9**

110.9 ± 6.3*Δ#

107.5 ± 5.4Δ#

105.4 ± 4.4

CO

2.99 ± 0.20

0.99 ± 0.06**

1.12 ± 0.03**

1.23 ± 0.04**Δ#

1.34 ± 0.08**Δ#

1.42 ± 0.07**Δ#

1.36 ± 0.08**

MAP

89.88 ± 3.22

117.2 ± 7.1**Δ#

115.5 ± 5.9**Δ#

111.8 ± 5.6**

103.6 ± 4.7**Δ#

99.8 ± 4.3*Δ#

94.5 ± 3.4

CPP

43.1 ± 3.34

27.6 ± 2.8**Δ

28.2 ± 2.9**Δ

32.4 ± 3.1**

35.4 ± 3.6*Δ#

36.5 ± 3.9Δ#

39.4 ± 4.3Δ

MPAP

24.6 ± 2.7

40.3 ± 5.6**Δ#

38.4 ± 4.1**Δ#

37.8 ± 4.1**Δ#

33.6 ± 3.5

29.8 ± 3.1Δ

28.7 ± 2.2Δ

Sildenafil + L-NANE group

HR

103.2 ± 7.22

128.4 ± 9.1**

125.6 ± 7.3

118.5 ± 7.2*

115.9 ± 6.6

112.6 ± 5.7Δ

104.7 ± 6.4

CO

2.99 ± 0.20

0.98 ± 0.07**

0.87 ± 0.05**

0.92 ± 0.06**

0.98 ± 0.04**

1.17 ± 0.05**

1.21 ± 0.06**

MAP

88.18 ± 3.22

121.2 ± 6.1**Δ

120.6 ± 7.4**

117.4 ± 6.4**

113.8 ± 6.7**

110.7 ± 4.6**

99.7 ± 4.6*

CPP

44.2 ± 3.52

24.8 ± 2.7**Δ

25.7 ± 2.8**

27.7 ± 2.6**

30.6 ± 3.2**

32.7 ± 3.6*

35.7 ± 3.4*

MPAP

24.6 ± 2.7

45.2 ± 5.4**Δ

46.2 ± 5.3**

44.7 ± 4.3**

38.4 ± 4.7**

36.9 ± 3.5*

34.3 ± 3.6*

  1. Values are mean ± SD (n)
  2. *p < 0.05 vs. baseline, **p < 0.01 vs. baseline, Δ P < 0.05 vs. SA group. # p < 0.05 vs. Sildenafil+L-NAME group. (Student t test was used for comparisons between every two groups. Partial pressures are given in mmHg. HCO3: bicarbonate in mM; Differences at different time points were compared with repeated-measures analysis of variance (ANOVA) with Bon-ferroni correction for post hoc comparison between multiple experimental groups)