|
Group
|
Parameter
|
Baseline
|
ROSC 0 min
|
ROSC 30 min
|
ROSC 1 h
|
ROSC 2 h
|
ROSC 4 h
|
ROSC 6 h
|
|---|
|
SA group
|
HR
|
101.3 ± 8.30
|
132.2 ± 11.3**
|
129.4 ± 10.4**
|
120.3 ± 8.9**
|
118.9 ± 9.3**
|
113.5 ± 17.4*
|
101.4 ± 10.4
|
|
CO
|
2.99 ± 0.20
|
0.91 ± 0.07**
|
0.88 ± 0.06**
|
0.89 ± 0.06**
|
0.91 ± 0.05**
|
1.04 ± 0.05**
|
1.15 ± 0.04**
|
|
MAP
|
91.88 ± 3.22
|
125.2 ± 7.3**
|
122.5 ± 6.4**
|
115.4 ± 6.1**
|
109.8 ± 5.7**
|
107.6 ± 5.1**
|
101.5 ± 4.8*
|
|
CPP
|
44.2 ± 4.12
|
22.3 ± 2.5**
|
23.4 ± 2.6**
|
25.6 ± 2.7**
|
29.7 ± 3.6**
|
32.5 ± 3.8*
|
33.8 ± 3.7*
|
|
MPAP
|
24.1 ± 2.2
|
49.7 ± 6.3**
|
47.3 ± 5.7**
|
43.8 ± 4.7**
|
39.7 ± 4.2**
|
35.8 ± 3.7*
|
35.1 ± 3.1*
|
|
Sildenafil group
|
HR
|
102.1 ± 7.30
|
123.2 ± 9.3**Δ#
|
118.4 ± 8.4**Δ#
|
115.3 ± 7.9**
|
110.9 ± 6.3*Δ#
|
107.5 ± 5.4Δ#
|
105.4 ± 4.4
|
|
CO
|
2.99 ± 0.20
|
0.99 ± 0.06**
|
1.12 ± 0.03**
|
1.23 ± 0.04**Δ#
|
1.34 ± 0.08**Δ#
|
1.42 ± 0.07**Δ#
|
1.36 ± 0.08**
|
|
MAP
|
89.88 ± 3.22
|
117.2 ± 7.1**Δ#
|
115.5 ± 5.9**Δ#
|
111.8 ± 5.6**
|
103.6 ± 4.7**Δ#
|
99.8 ± 4.3*Δ#
|
94.5 ± 3.4
|
|
CPP
|
43.1 ± 3.34
|
27.6 ± 2.8**Δ
|
28.2 ± 2.9**Δ
|
32.4 ± 3.1**
|
35.4 ± 3.6*Δ#
|
36.5 ± 3.9Δ#
|
39.4 ± 4.3Δ
|
|
MPAP
|
24.6 ± 2.7
|
40.3 ± 5.6**Δ#
|
38.4 ± 4.1**Δ#
|
37.8 ± 4.1**Δ#
|
33.6 ± 3.5*Δ
|
29.8 ± 3.1Δ
|
28.7 ± 2.2Δ
|
|
Sildenafil + L-NANE group
|
HR
|
103.2 ± 7.22
|
128.4 ± 9.1**
|
125.6 ± 7.3*Δ
|
118.5 ± 7.2*
|
115.9 ± 6.6*Δ
|
112.6 ± 5.7Δ
|
104.7 ± 6.4
|
|
CO
|
2.99 ± 0.20
|
0.98 ± 0.07**
|
0.87 ± 0.05**
|
0.92 ± 0.06**
|
0.98 ± 0.04**
|
1.17 ± 0.05**
|
1.21 ± 0.06**
|
|
MAP
|
88.18 ± 3.22
|
121.2 ± 6.1**Δ
|
120.6 ± 7.4**
|
117.4 ± 6.4**
|
113.8 ± 6.7**
|
110.7 ± 4.6**
|
99.7 ± 4.6*
|
|
CPP
|
44.2 ± 3.52
|
24.8 ± 2.7**Δ
|
25.7 ± 2.8**
|
27.7 ± 2.6**
|
30.6 ± 3.2**
|
32.7 ± 3.6*
|
35.7 ± 3.4*
|
|
MPAP
|
24.6 ± 2.7
|
45.2 ± 5.4**Δ
|
46.2 ± 5.3**
|
44.7 ± 4.3**
|
38.4 ± 4.7**
|
36.9 ± 3.5*
|
34.3 ± 3.6*
|
- Values are mean ± SD (n)
- *p < 0.05 vs. baseline, **p < 0.01 vs. baseline, Δ P < 0.05 vs. SA group. # p < 0.05 vs. Sildenafil+L-NAME group. (Student t test was used for comparisons between every two groups. Partial pressures are given in mmHg. HCO3: bicarbonate in mM; Differences at different time points were compared with repeated-measures analysis of variance (ANOVA) with Bon-ferroni correction for post hoc comparison between multiple experimental groups)
