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Table 3 Sensitivity, specificity, predictive values, likelihood ratios and AUCs of the final models*

From: The predictive value of variables measurable in the ambulance and the development of the Predict Sepsis screening tools: a prospective cohort study

ModelPredict Sepsis screening tool 1Model 5Model 6Model 7Predict Sepsis screening tool 2Predict Sepsis screening tool 3
Included variables and their scoresAcute altered mental status = 1
Gastrointestinal symptoms = 1
SBP ≤ 100 = 2
GCS < 15 = 2
Temp 38.1–38.5 = 1
>38.5 = 2
Lactate> 4 = 2
Acute altered mental status and/or GCS < 15 = 2
Gastrointestinal symptoms = 1
SBP ≤ 100 = 2
Temp 38.1–38.5 = 1
> 38.5 = 2
Lactate> 4 = 2
Acute altered mental status and/or GCS < 15 = 2
Gastrointestinal symptoms = 1
SBP ≤ 100 = 2
Temp
38.1–38.5 = 1
> 38.5 = 2
Acute altered mental status and/or GCS < 15 = 1
Gastrointestinal symptoms = 1
SBP ≤ 100 = 2
Temp
38.1–38.5 = 1
> 38.5 = 2
Lactate> 4 = 2
Acute altered mental status and/or GCS < 15 = 1
Gastrointestinal symptoms = 1
SBP ≤ 100 = 2
Temp
38.1–38.5 = 1
> 38.5 = 2
RR > 24 = 1
SpO2 < 94 = 1
HR > 110 = 1
SBP ≤ 100 = 2
GCS <15 = 2
Temp 38.1–38.5 = 1
> 38.5 = 2
Total score considered positive for suspected sepsis≥2≥2≥2≥2≥2≥2
Sensitivity (95%CI)0.90 (0.85–0.94)0.92 (0.88–0.96)0.92 (0.87–0.95)0.87 (0.82–0.92)0.86 (0.80–0.90)0.91 (0.86–0.94)
Specificity (95%CI)0.41 (0.35–0.47)0.27 (0.22–0.33)0.27 (0.22–0.33)0.48 (0.42–0.54)0.48 (0.42–0.54)0.38 (0.33–0.44)
PPV (95%CI)0.52 (0.47–0.58)0.48 (0.43.0.53)0.48 (0.43–0.53)0.55 (0.49–0.60)0.54 (0.49–0.60)0.51 (0.46–0.57)
NPV (95%CI)0.86 (0.78–0.91)0.84 (0.74–0.90)0.83 (0.73–0.89)0.84 (0.77–0.89)0.83 (0.76–0.88)0.85 (0.78–0.91)
Pos LR (95%CI)1.54 (1.38–1.71)1.27 (1.17–1.38)1.27 (1.17–1.38)1.67 (1.48–1.89)1.65 (1.46–1.88)1.47 (1.33–1.63)
Neg LR (95%CI)0.23 (0.15–0.36)0.27 (0.17–0.46)0.29 (0.18–0.48)0.26 (0.18–0.38)0.29 (0.21–0.42)0.24 (0.15–0.37)
AUC for sum of scores for the model (95%CI)0.77 (0.73–0.81)0.75 (0.70–0.79)0.74 (0.69–0.78)0.75 (0.70–0.79)0.74 (0.69–0.78)0.76 (0.72–0.81)
  1. PPV positive predictive value, NPV positive predictive value, LR likelihood ratio, AUC area under the curve, CI confidence interval, SBP Systolic blood pressure, GCS Glasgow coma scale, Temp Temperature
  2. *Sensitivity, specificity, PPV, NPV, LRs and 95% confidence intervals for those were calculated by using www.vassarstats.net, Clinical research calculators, calculator 1
  3. Curved text indicates a keyword related to medical history
  4. Bold text indicates models chosen as the Predict Sepsis screening tools