Fluid resuscitation with preventive peritoneal dialysis attenuates crush injury-related acute kidney injury and improves survival outcome

Table 1 Arterial blood gases and lactate (mean ± SD)

	Group	Baseline	Compression	Resuscitation
pH	Con	7.34 ± 0.03	7.44 ± 0.05^††	7.30 ± 0.15^†††**
	MFR	7.35 ± 0.03	7.43 ± 0.02^†	7.38 ± 0.06^#
	PPD	7.34 ± 0.02	7.42 ± 0.04^††	7.42 ± 0.05^†##
	MFR + PPD	7.35 ± 0.03	7.42 ± 0.03^†	7.40 ± 0.03^##
BE (mmol/L)	Con	1.3 ± 1.2	0.5 ± 1.3^†	−4.8 ± 1.6^†††***
	MFR	1.8 ± 2.0	1.0 ± 0.8^†	−1.2 ± 1.4^††###**
	PPD	1.5 ± 1.2	0.7 ± 1.2^†	−1.5 ± 1.7^††###**
	MFR + PPD	1.7 ± 1.0	0.9 ± 0.7^†	−1.2 ± 0.9^††###**
PaCO₂ (mmHg)	Con	48 ± 9	36 ± 8^††	28 ± 6^†††**
	MFR	50 ± 11	42 ± 14^†	28 ± 5^†††**
	PPD	50 ± 13	33 ± 12^†††	32 ± 12^†††
	MFR + PPD	49 ± 10	37 ± 10^††	30 ± 10^†††*
PaO₂ (mmHg)	Con	91 ± 9	92 ± 5	122 ± 14^†††***
	MFR	89 ± 12	93 ± 7	112 ± 20^†††#**
	PPD	91 ± 13	93 ± 9	112 ± 17^†††#**
	MFR + PPD	88 ± 10	92 ± 7	114 ± 19^†††#**
Lactate (mmol/L)	Con	1.0 ± 0.4	2.5 ± 0.9^†††	5.7 ± 1.2^†††**
	MFR	0.9 ± 0.3	2.1 ± 0.4^†††	2.8 ± 0.5^†††*##
	PPD	1.1 ± 0.4	2.1 ± 0.4^††	2.2 ± 1.0^†††###
	MFR + PPD	0.8 ± 0.3	1.6 ± 0.5^††	1.9 ± 0.6^†††###

BE base excess, Con control group, MFR massive fluid resuscitation, PPD preventive peritoneal dialysis. In each group, number of animals ≥5 at all time points. ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. Control group; ^† p < 0.05, ^†† p < 0.01, ^††† p < 0.001 vs. Baseline; ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001 vs. Compression

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